Function of a Heterologous Muscarinic Receptor in T Cell Antigen Receptor Signal Transduction Mutants

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

1979 • 1,480 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

1987 • 766 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

1988 • 669 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

Molecular Properties of the Muscarinic Acetylcholine Receptor

1987 • 478 citations

Polymorphism in mitogenic effect of IgG1 monoclonal antibodies against T3 antigen on human T cells

1983 • 333 citations

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

1985 • 299 citations

Cell Surface Molecules and Early Events Involved in Human T Lymphocyte Activation

1987 • 297 citations

Structure, Function, and Serology of the T-Cell Antigen Receptor Complex

1987 • 264 citations

Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell

1989 • 259 citations

Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes

1987 • 247 citations

Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium.

1986 • 202 citations

Early Signal Transduction by the Antigen Receptor Without Commitment to T Cell Activation

1988 • 169 citations

Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer.

1986 • 168 citations

Multiple kinases and signal transduction. Phosphorylation of the T cell antigen receptor complex.

1987 • 168 citations

Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex

1987 • 159 citations

Identification and sequence of a fourth human T cell antigen receptor chain

1987 • 157 citations

Human T cell activation. I. Monocyte-independent activation and proliferation induced by anti-T3 monoclonal antibodies in the presence of tumor promoter 12-o-tetradecanoyl phorbol-13 acetate.

1985 • 155 citations

The T11 (CD2) molecule is functionally linked to the T3/Ti T cell receptor in the majority of T cells.

1987 • 148 citations

Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

1987 • 141 citations

The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.

1988 • 131 citations

Two monoclonal anti-human T lymphocyte antibodies have similar biologic effects and recognize the same cell surface antigen.

1982 • 123 citations

T Cell CD3-ζη Heterodimer Expression and Coupling to Phosphoinositide Hydrolysis

1988 • 113 citations

T cell receptor/CD3 negative variants are unresponsive to stimulation through the Ly-6 encoded molecule, TAP.

1988 • 44 citations

Triggering of cytotoxic T lymphocytes and NK cells via the Tp103 pathway is dependent on the expression of the T cell receptor/CD3 complex.

1988 • 43 citations

At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.

1988 • 42 citations

Bacterial toxins affect early events of T lymphocyte activation.

1989 • 42 citations

Muscarinic receptor-mediated hydrolysis of phosphatidylinositols in human neuroblastoma (SH-SY5Y) cells is sensitive to pertussis toxin

1988 • 21 citations

Polyphosphoinositide labeling in rat liver plasma membranes is reduced by preincubation with cholera toxin.

1987 • 19 citations

Expression of a functional CD3-Ti antigen/MHC receptor in the absence of surface CD2. Analysis with clonal Jurkat cell mutants.

1988 • 18 citations

Generation and Analysis of a T‐Lymphocyte Somatic Mutant for Studying Molecular Aspects of Signal Transduction by the Antigen Receptora

1988 • 7 citations