Calcium binding to the epidermal growth factor homology region of bovine protein C.

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

Polyacrylamide Gel Electrophoresis of Viral Proteins

1971 • 1,477 citations

Deficiency of protein C in congenital thrombotic disease.

1981 • 1,260 citations

Enzymatic iodination of polypeptides with 125I to high specific activity

1971 • 1,170 citations

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 831 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

Agarose Gel Electrophoresis

1972 • 670 citations

A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization.

1976 • 634 citations

Human Plasma Protein C

1979 • 511 citations

Preparation and properties of bovine factor VIII (antihemophilic factor)

1980 • 504 citations

Anticoagulant properties of bovine plasma protein C following activation by thrombin

1977 • 495 citations

The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V

1979 • 480 citations

Characterization of a cDNA coding for human factor VII.

1986 • 450 citations

Homozygous Protein C Deficiency Manifested by Massive Venous Thrombosis in the Newborn

1984 • 444 citations

The Regulation of Hemostasis: The Protein C System

1986 • 443 citations

Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme

1982 • 385 citations

Vitamin K Metabolism and Vitamin K Dependent Proteins

1980 • 375 citations

Inactivation of human coagulation factor V by activated protein C.

1983 • 374 citations

The gene structure of human anti-haemophilic factor IX.

1984 • 361 citations

The nucleotide sequence of the gene for human protein C.

1985 • 360 citations

Vitamin K-Dependent Formation of γ-Carboxyglutamic Acid

1977 • 357 citations

Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 330 citations

The solution structure of human epidermal growth factor

1987 • 322 citations

Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme

1982 • 308 citations

Activated protein C decreases plasminogen activator-inhibitor activity in endothelial cell-conditioned medium

1985 • 305 citations

Generation of fibrinolytic activity by infusion of activated protein C into dogs.

1981 • 303 citations

Proteolytic activation of protein C from bovine plasma

1976 • 211 citations

Gene for human factor X: a blood coagulation factor whose gene organization is essentially identical with that of factor IX and protein C

1986 • 204 citations

Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C.

1983 • 202 citations

Protein-C: biochemistry, physiology, and clinical implications

1983 • 194 citations

Protein-C: biochemistry, physiology, and clinical implications

1983 • 169 citations

Evolution and organization of the human protein C gene.

1986 • 169 citations

Beta-hydroxyaspartic acid in vitamin K-dependent proteins.

1983 • 163 citations

Amino acid sequence of the light chain of bovine protein C.

1982 • 162 citations

beta-Hydroxyasparagine in domains homologous to the epidermal growth factor precursor in vitamin K-dependent protein S.

1987 • 160 citations

Vitamin K and the Biosynthesis of Prothrombin

1972 • 146 citations

Vitamin K and the biosynthesis of prothrombin. V. Gamma-carboxyglutamic acids, the vitamin K-dependent structures in prothrombin.

1975 • 143 citations

Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as .beta.-hydroxyaspartic acid

1983 • 142 citations

beta-Hydroxyaspartic acid in vitamin K-dependent protein C.

1983 • 138 citations

A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase.

1976 • 134 citations

Structure-function relationships in EF-hand calcium-binding proteins. Protein engineering and biophysical studies of calbindin D9k

1987 • 131 citations

Structural changes required for activation of protein C are induced by Ca2+ binding to a high affinity site that does not contain gamma-carboxyglutamic acid.

1983 • 127 citations

Structure and Function of Protein C

1984 • 112 citations

Amino acid sequence of the heavy chain of bovine protein C.

1982 • 110 citations

Derivatives of blood coagulation factor IX contain a high affinity Ca2+-binding site that lacks gamma-carboxyglutamic acid.

1984 • 101 citations

Calcium-binding properties of bovine factor X lacking the gamma-carboxyglutamic acid-containing region.

1984 • 96 citations

Vitamin K and the Biosynthesis of Prothrombin

1973 • 93 citations

beta-Hydroxyaspartic acid or beta-hydroxyasparagine in bovine low density lipoprotein receptor and in bovine thrombomodulin.

1988 • 93 citations

The occurrence of β-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens

1983 • 88 citations

Preparation and properties of derivatives of bovine factor X and factor Xa from which the gamma-carboxyglutamic acid containing domain has been removed.

1986 • 67 citations

Calcium-dependent interaction between the epidermal growth factor precursor-like region of human protein C and a monoclonal antibody.

1987 • 65 citations

Calcium binding of bovine protein S. Effect of thrombin cleavage and removal of the gamma-carboxyglutamic acid-containing region.

1986 • 54 citations

Calcium binding to a human factor IXa derivative lacking γ-carboxyglutamic acid: Evidence for two high-affinity sites that do not involve β-hydroxyaspartic acid

1985 • 46 citations

Stimulation of the amidase and esterase activity of activated bovine plasma protein C by monovalent cations

1980 • 46 citations

erythro‐β‐hydroxyaspartic acid in bovine factor IX and factor X

1984 • 30 citations

The effect of divalent cations on the amidolytic activity of bovine plasma activated protein C and des-1-41-light chain activated protein C.

1987 • 8 citations