The gene structure of human anti-haemophilic factor IX.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

1975 • 3,483 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Analysis of gene control signals by DNA fusion and cloning in Escherichia coli

1980 • 2,499 citations

Lambda replacement vectors carrying polylinker sequences

1983 • 1,809 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Trans-complementable copy-number mutants of plasmid ColE1

1980 • 975 citations

A mew computer method for the storage and manipulation of DNA gel reading data

1980 • 679 citations

Base sequence studies of 300 nucleotide renatured repeated human DNA clones

1981 • 605 citations

The nucleotide sequence of the initiation and termination sites for ribosomal rna transcription in x. laevis

1979 • 579 citations

Isolation and characterization of a cDNA coding for human factor IX.

1982 • 415 citations

Novel bacteriophage lambda cloning vector.

1980 • 404 citations

Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I.

1978 • 395 citations

Filter replicas and permanent collections of recombinant DNA plasmids

1979 • 355 citations

Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin

1983 • 299 citations

Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides

1983 • 295 citations

Molecular cloning of the gene for human anti-haemophilic factor IX

1982 • 272 citations

Functional relationships between transcriptional control signals of the thymidine kinase gene of herpes simplex virus

1982 • 253 citations

Structure and in Vitro Transcription of Human Globin Genes

1980 • 231 citations

Structure and genomic organization of the mouse dihydrofolate reductase gene

1980 • 218 citations

Gene deletions in patients with haemophilia B and anti-factor IX antibodies

1983 • 207 citations

AUG is the only recognisable signal sequence in the 5′ non-coding regions of eukaryotic mRNA

1978 • 172 citations

Messenger rna for the ad2 dna binding protein: dna sequences encoding the first leader and heterogeneity at the mRNA 5′ end

1979 • 166 citations

Isolation of a human anti-haemophilic factor IX cDNA clone using a unique 52-base synthetic oligonucleotide probe deduced from the amino acid sequence of bovine factor IX

1983 • 163 citations

Regional localization on the human X chromosome and polymorphism of the coagulation factor IX gene (hemophilia B locus).

1984 • 161 citations

Intron–exon splice junctions map at protein surfaces

1982 • 148 citations

Comparison of amino acid sequence of bovine coagulation Factor IX (Christmas Factor) with that of other vitamin K-dependent plasma proteins.

1979 • 147 citations

The sequence of the nucleoprotein gene of human influenza A virus, strain A/NT/60/68

1982 • 141 citations

beta-Hydroxyaspartic acid in vitamin K-dependent protein C.

1983 • 138 citations

CHARACTERISATION AND USE OF AN INTRAGENIC POLYMORPHIC MARKER FOR DETECTION OF CARRIERS OF HAEMOPHILIA B (FACTOR IX DEFICIENCY)

1984 • 127 citations

Isolation of a genomic clone partially encoding human hypoxanthine phosphoribosyltransferase.

1982 • 117 citations

Molecular cloning and characterization of the gene coding for human complement protein factor B.

1983 • 103 citations

Complete nucleotide sequence of the 5′ noncoding region of human α- and β-globin mRNA

1977 • 81 citations

CARRIER DETECTION BY DIRECT GENE ANALYSIS IN A FAMILY WITH HAEMOPHILIA B (FACTOR IX DEFICIENCY)

1984 • 58 citations

Assignment of the haemophilia B (Factor IX) locus to the q26‐qter region of the X chromosome

1984 • 54 citations