Protective effect of HO-1 against oxidative stress in human hepatoma cell line (HepG2) is independent of telomerase enzyme activity

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

1989 • 1,607 citations

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

1999 • 1,237 citations

Heme oxygenase: colors of defense against cellular stress

2000 • 869 citations

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

1995 • 849 citations

Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3

1997 • 834 citations

Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury

1999 • 694 citations

Correlating telomerase activity levels with human neuroblastoma outcomes

1995 • 631 citations

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts

2000 • 532 citations

Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation

1994 • 512 citations

Cell and tissue responses to oxidative damage.

1993 • 492 citations

Transcriptional control of rat heme oxygenase by heat shock.

1987 • 415 citations

Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene.

1994 • 401 citations

Functional Evidence for an RNA Template in Telomerase

1990 • 392 citations

Neurons Overexpressing Heme Oxygenase‐1 Resist Oxidative Stress‐Mediated Cell Death

2000 • 351 citations

Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity.

1995 • 343 citations

A critical role for telomeres in suppressing and facilitating carcinogenesis

2000 • 314 citations

Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts

2000 • 296 citations

Requirement of Caspase-3(-like) Protease-mediated Hydrogen Peroxide Production for Apoptosis Induced by Various Anticancer Drugs

1998 • 271 citations

Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress

1998 • 237 citations

Telomerase activity in human brain tumours

1995 • 217 citations

Gene transfer of human heme oxygenase into coronary endothelial cells potentially promotes angiogenesis

1998 • 213 citations

Telomerase activity in bladder carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine

1997 • 204 citations

High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic Stage

1997 • 194 citations

Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions.

1995 • 191 citations

Overexpression of the Heme Oxygenase Gene in Renal Cell Carcinoma

1997 • 187 citations

Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution

1996 • 187 citations

Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium

2000 • 179 citations

Human Heme Oxygenase-1 Gene Transfer Lowers Blood Pressure and Promotes Growth in Spontaneously Hypertensive Rats

2001 • 159 citations

Specific NF‐κB blockade selectively inhibits tumour necrosis factor‐α‐induced COX‐2 but not constitutive COX‐1 gene expression in HT‐29 cells

1998 • 139 citations

Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury

1999 • 126 citations

Regulation of heme oxygenase-2 by glucocorticoids in neonatal rat brain: characterization of a functional glucocorticoid response element

1997 • 125 citations

Human telomerase reverse transcriptase as a critical determinant of telomerase activity in normal and malignant endometrial tissues

1999 • 116 citations

Hydroxyl radical‐induced apoptosis in human tumor cells is associated with telomere shortening but not telomerase inhibition and caspase activation

2001 • 93 citations

Protective effect of ebselen against hydrogen peroxide-induced cytotoxicity and DNA damage in HepG2 cells

1999 • 91 citations

A Single Dose of Sn-Mesoporphyrin Prevents Development of Severe Hyperbilirubinemia in Glucose-6-Phosphate Dehydrogenase-Deficient Newborns

2001 • 81 citations

Presence of heme oxygenase and NADPH cytochrome P-450 (c) reductase in human corneal epithelium.

1987 • 78 citations

Expression of telomerase inhibits hydroxyl radical‐induced apoptosis in normal telomerase negative human lung fibroblasts

2001 • 76 citations

Quantitative measurement of telomerase reverse transcriptase (hTERT) mRNA in urothelial cell carcinomas

2000 • 75 citations

Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin

1989 • 71 citations

Regulation of human heme oxygenase in endothelial cells by using sense and antisense retroviral constructs

2001 • 55 citations

Transient induction of heme oxygenase after cortical stab wound injury

1996 • 46 citations

Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells

2002 • 39 citations

Telomerase activity in hepatocellular carcinoma and adjacent liver tissues

1998 • 33 citations

Alterations in microsomal drug metabolism and heme oxygenase activity in isolated hepatic parenchymal and sinusoidal cells in Murphy-Sturm lymphosarcoma-bearing rats.

1986 • 27 citations

Expression of telomerase genes correlates with telomerase activity in human colorectal carcinogenesis

2001 • 26 citations

A High Expression of Heme Oxygenase-1 in the Liver of LEC Rats at the Stage of Hepatoma: The Possible Implication of Induction in Uninvolved Tissue

1998 • 17 citations

Heme oxygenase-1 gene expression as a stress index to ocular irritation

1999 • 15 citations

Telomerase and oral cancer

2001 • 15 citations

TNF-alpha-induced inhibition of PC synthesis by human type II pneumocytes is sequentially mediated by PGE2 and NO

1996 • 15 citations