T Cell Proliferation Induced by Autologous Non-T Cells Is a Response to Apoptotic Cells Processed by Dendritic Cells

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

Caspase activation: The induced-proximity model

1999 • 920 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1998 • 843 citations

Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis

1999 • 829 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

1998 • 649 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status

1999 • 484 citations

Caspase Activation Is Required for T Cell Proliferation

1999 • 462 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis.

1995 • 392 citations

Human dendritic cells. Enrichment and characterization from peripheral blood

1982 • 389 citations

Early Activation of Caspases during T Lymphocyte Stimulation Results in Selective Substrate Cleavage in Nonapoptotic Cells

1999 • 387 citations

αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells

2000 • 375 citations

Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function.

1998 • 353 citations

Autologous stimulation of human lymphocyte subpopulation.

1975 • 323 citations

A role for CD36 in the regulation of dendritic cell function

2001 • 315 citations

Lymphocyte transformation induced by autologous cells. IV. Human T-lymphocyte proliferation induced by autologous or allogeneic non-T lymphocytes.

1976 • 298 citations

Cutting Edge: Bystander Apoptosis Triggers Dendritic Cell Maturation and Antigen-Presenting Function

1998 • 295 citations

Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine.

1995 • 293 citations

High Levels of a Major Histocompatibility Complex II–Self Peptide Complex on Dendritic Cells from the T Cell Areas of Lymph Nodes

1997 • 292 citations

Inhibitory Effects of Apoptotic Cell Ingestion upon Endotoxin-Driven Myeloid Dendritic Cell Maturation

2002 • 285 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

Proteins Phosphorylated during Stress-induced Apoptosis Are Common Targets for Autoantibody Production in Patients with Systemic Lupus Erythematosus

1997 • 223 citations

Human dendritic cells: major stimulators of the autologous and allogeneic mixed leucocyte reactions.

1982 • 168 citations

Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus.

1995 • 165 citations

Activation of suppressor T cells in human autologous mixed lymphocyte culture.

1979 • 160 citations

Evidence for CPP32 Activation in the Absence of Apoptosis during T Lymphocyte Stimulation

1997 • 155 citations

Specificity and Suppressor Function of Human T Cells Responsive to Autologous Non-T Cells

1979 • 148 citations

Histone‐specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double‐stranded DNA antibody production

1997 • 141 citations

Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells.

1995 • 125 citations

Cleavage of Poly(ADP-Ribose) Polymerase Measured in Situ in Individual Cells: Relationship to DNA Fragmentation and Cell Cycle Position during Apoptosis

2000 • 124 citations

Activation of Suppressor T Cells in Human Autologous Mixed Lymphocyte Culture

1979 • 119 citations

Common Regulation of Apoptosis Signaling Induced by CD95 and the DNA-damaging Stimuli Etoposide and γ-Radiation Downstream from Caspase-8 Activation

1999 • 114 citations

Induction of suppressor activity in the autologous mixed lymphocyte reaction and in cultures with concanavalin A.

1979 • 112 citations

The spontaneous apoptotic cell death of normal human lymphocytes in vitro: The release of, and immunoproliferative response to, nucleosomes in vitro

1991 • 108 citations

Acetylcholine receptor-reactive T and B cells in myasthenia gravis and controls.

1991 • 108 citations

In vivopriming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen

1998 • 108 citations

Apoptotic cells overexpress vinculin and induce vinculin-specific cytotoxic T-cell cross-priming

2001 • 89 citations

Immunoregulatory activities of autoreactive T cells: an I-A-specific T cell clone mediates both help and suppression of antibody responses.

1984 • 87 citations

Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity.

1993 • 84 citations

Peripheral tolerance of CD4 T cells following local activation in adolescent mice

1996 • 82 citations

LYMPHOCYTE TRANSFORMATION INDUCED BY AUTOLOGOUS CELLS

1973 • 79 citations

Autoantibody recognition of distinctly modified forms of the U1–70-kd antigen is associated with different clinical disease manifestations

2000 • 78 citations

Change in the frequency of apoptosis after low- and high-dose X-irradiation of human lymphocytes

1992 • 75 citations

Human T cell clones reactive against U-small nuclear ribonucleoprotein autoantigens from connective tissue disease patients and healthy individuals.

1993 • 74 citations

Quantification of apoptosis in lymphocyte subsets and effect of apoptosis on apparent expression of membrane antigens

1997 • 73 citations

T cell response to myelin basic protein epitopes in multiple sclerosis patients and healthy subjects

1991 • 70 citations

Surges of Increased T Cell Reactivity to an Encephalitogenic Region of Myelin Proteolipid Protein Occur More Often in Patients with Multiple Sclerosis Than in Healthy Subjects

2000 • 64 citations

Induction of Fas Ligand-Mediated Apoptosis by Interferon-α

2000 • 62 citations

Stimulation of Human Peripheral Blood Lymphocytes by Periodate, Galactose Oxidase, Soybean Agglutinin, and Peanut Agglutinin: Differential Effects of Adherent Cells

1977 • 58 citations

Analysis of human t cell and b cell responses against u small nuclear ribonucleoprotein 70‐kd, b, and d polypeptides among patients with systemic lupus erythematosus and mixed connective tissue disease

1997 • 54 citations

Autoantigen-specific T cell proliferation induced by the ribosomal P2 protein in patients with systemic lupus erythematosus.

1994 • 51 citations

Detection and epitope analysis of autoantigen-reactive T cells to the U1-small nuclear ribonucleoprotein A protein in autoimmune disease patients.

1993 • 50 citations

Origin and specificity of autoreactive T cells in antigen-induced populations.

1985 • 49 citations

Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors.

1993 • 48 citations

T-cell epitopes on the 70-kDa protein of the (U1)RNP complex in autoimmune rheumatologic disorders

1990 • 43 citations

Exogenously Provided Peptides of a Self-antigen Can Be Processed into Forms that Are Recognized by Self–T Cells

1998 • 38 citations

Autocytotoxic and autosuppressor T-cell lines generated from autologous lymphocyte cultures

1987 • 21 citations

Immune responses to self peptides naturally presented by murine class II Major Histocompatibility Complex molecules

1996 • 20 citations

T cell lines recognizing the 70-kD protein of U1 small nuclear ribonucleoprotein (U1snRNP)

1995 • 18 citations

Activation and function of an autoreactive T cell clone with dual immunoregulatory activity.

1988 • 11 citations