Class I and III Phosphatidylinositol 3′-Kinase Play Distinct Roles in TLR Signaling Pathway

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2003 • 3,689 citations

CpG Motifs in Bacterial DNA and Their Immune Effects

2002 • 2,520 citations

TLR signaling pathways

2004 • 2,359 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

2004 • 1,326 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

2003 • 1,189 citations

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells

2000 • 1,125 citations

Recognition of pathogen-associated molecular patterns by TLR family

2003 • 1,124 citations

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

2004 • 946 citations

PI3K in lymphocyte development, differentiation and activation

2003 • 739 citations

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

2002 • 724 citations

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

2004 • 719 citations

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

1998 • 667 citations

Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway

2000 • 663 citations

PI3K and negative regulation of TLR signaling

2003 • 601 citations

PI3K-mediated negative feedback regulation of IL-12 production in DCs

2002 • 534 citations

PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane Trafficking

1998 • 515 citations

Immune Cell Activation by Bacterial Cpg-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor–Associated Factor (Traf)6

2000 • 472 citations

The role of PI3K in immune cells

2003 • 460 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Molecular mechanisms of endotoxin tolerance

2004 • 423 citations

Human TLR10 Is a Functional Receptor, Expressed by B Cells and Plasmacytoid Dendritic Cells, Which Activates Gene Transcription through MyD88

2005 • 412 citations

Phosphatidylinositol 3‐kinase is involved in Toll‐like receptor 4‐mediated cytokine expression in mouse macrophages

2003 • 316 citations

Phosphoinositide 3-kinase in immunological systems

2002 • 206 citations

Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9

2004 • 189 citations

RETRACTED: DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA

2000 • 180 citations

Human VPS34 and p150 are Rab7 Interacting Partners

2003 • 166 citations

Plasmacytoid dendritic cells: the key to CpG

2002 • 155 citations

Distinct Roles for the p110α and hVPS34 Phosphatidylinositol 3′-Kinases in Vesicular Trafficking, Regulation of the Actin Cytoskeleton, and Mitogenesis

1998 • 150 citations

Phosphoinositide 3-Kinase and Akt Occupy Central Roles in Inflammatory Responses of Toll-Like Receptor 2-Stimulated Neutrophils

2004 • 138 citations

The role of TRAF6 in signal transduction and the immune response

2004 • 134 citations

Potential Role of Phosphatidylinositol 3 Kinase, rather than DNA-dependent Protein Kinase, in CpG DNA–induced Immune Activation

2002 • 131 citations

PTEN Blocks Tumor Necrosis Factor-induced NF-κB-dependent Transcription by Inhibiting the Transactivation Potential of the p65 Subunit

2002 • 122 citations

Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-β

2000 • 112 citations

Wortmannin, a Specific Inhibitor of Phosphatidylinositol-3-kinase, Enhances LPS-Induced NO Production from Murine Peritoneal Macrophages

1997 • 108 citations

PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase

2004 • 99 citations

Influence of Coinfecting Pathogens on HIV Expression: Evidence for a Role of Toll-Like Receptors

2004 • 99 citations

Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells

2001 • 48 citations

The induction of Toll-like receptor tolerance enhances rather than suppresses HIV-1 gene expression in transgenic mice

2003 • 30 citations

Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses

2004 • 27 citations