Myristoyl‐CoA: protein N‐myristoyltransferase activity in cancer cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

Characterization of membrane proteins in detergent solutions

1976 • 853 citations

THE BIOLOGY AND ENZYMOLOGY OF EUKARYOTIC PROTEIN ACYLATION

1988 • 787 citations

Molecular Targets for AIDS Therapy

1990 • 736 citations

New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral Activity

1989 • 689 citations

The Marcks brothers: A family of protein kinase C substrates

1992 • 474 citations

n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle.

1982 • 395 citations

Identification of the NH₂‐terminal blocking group of calcineurin B as myristic acid

1982 • 312 citations

Myristylation site in Pr65gag is essential for virus particle formation by Moloney murine leukemia virus.

1986 • 300 citations

Use of esters of N-hydroxysuccinimide in the synthesis of N-acylamino acids

1967 • 298 citations

Protein N-myristoylation

1991 • 289 citations

Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

1991 • 287 citations

G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.

1990 • 277 citations

Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.

1987 • 276 citations

Lipid modifications of G protein subunits.

1991 • 274 citations

Fatty Acylation of Proteins

1988 • 253 citations

Purification and characterization of yeast myristoyl CoA:protein N-myristoyltransferase.

1987 • 241 citations

Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformation

1986 • 223 citations

Amino-terminal processing of proteins by N-myristoylation. Substrate specificity of N-myristoyl transferase.

1987 • 220 citations

Specificity of fatty acid acylation of cellular proteins.

1985 • 213 citations

Fatty acylated proteins as components of intracellular signaling pathways

1990 • 202 citations

Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase.

1989 • 192 citations

Myristoyl CoA:protein N-myristoyltransferase activities from rat liver and yeast possess overlapping yet distinct peptide substrate specificities.

1988 • 187 citations

Activation of the Cellular Proto-Oncogene Product p21Ras by Addition of a Myristylation Signal

1989 • 158 citations

Cloning of rat hepatic lipase cDNA: evidence for a lipase gene family.

1987 • 153 citations

Identification of the NH2-terminal blocking group of NADH-cytochrome b5 reductase as myristic acid and the complete amino acid sequence of the membrane-binding domain.

1984 • 145 citations

Protein fatty acid acylation: enzymatic synthesis of an N-myristoylglycyl peptide.

1986 • 123 citations

Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae.

1992 • 115 citations

Developments of Cancer Chemotherapy

1980 • 113 citations

Myristylation of gag-onc fusion proteins in mammalian transforming retroviruses

1984 • 107 citations

Myristoylation ofgagProteins of HIV-1 Plays an Important Role in Virus Assembly

1990 • 106 citations

Effect of myristoylation on p27nef subcellular distribution and suppression of HIV-LTR transcription

1992 • 101 citations

Role of myristoylation of poliovirus capsid protein VP4 as determined by site-directed mutagenesis of its N-terminal sequence.

1989 • 99 citations

The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Analysis of myristic acid analogs containing oxygen, sulfur, double bonds, triple bonds, and/or an aromatic residue

1991 • 94 citations

Replication of human immunodeficiency virus 1 and Moloney murine leukemia virus is inhibited by different heteroatom-containing analogs of myristic acid.

1989 • 92 citations

Lysine residues form an integral component of a novel NH2-terminal membrane targeting motif for myristylated pp60v-src.

1992 • 91 citations

Heteroatom-substituted fatty acid analogs as substrates for N-myristoyltransferase: an approach for studying both the enzymology and function of protein acylation.

1988 • 80 citations

4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I.

1992 • 79 citations

Lack of myristoylation of poliovirus capsid polypeptide VP0 prevents the formation of virions or results in the assembly of noninfectious virus particles

1990 • 77 citations

Targets and strategies for the antiviral chemotherapy of AIDS

1990 • 77 citations

N-myristoyl transferase assay using phosphocellulose paper binding

1991 • 75 citations

Incorporation of 12-methoxydodecanoate into the human immunodeficiency virus 1 gag polyprotein precursor inhibits its proteolytic processing and virus production in a chronically infected human lymphoid cell line.

1991 • 70 citations

11-(Ethylthio)undecanoic acid. A myristic acid analogue of altered hydrophobicity which is functional for peptide N-myristoylation with wheat germ and yeast acyltransferase.

1988 • 69 citations

Structural and functional studies of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase produced in Escherichia coli. Evidence for an acyl-enzyme intermediate.

1990 • 68 citations

Analyzing the substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase by co-expressing it with mammalian G protein alpha subunits in Escherichia coli

1991 • 67 citations

Myristylation of a duck hepatitis B virus envelope protein is essential for infectivity but not for virus assembly

1991 • 61 citations

N-myristoylation of p60src. Identification of a myristoyl-CoA:glycylpeptide N-myristoyltransferase in rat tissues

1988 • 60 citations

S-(2-oxopentadecyl)-CoA, a nonhydrolyzable analog of myristoyl-CoA, is a potent inhibitor of myristoyl-CoA: protein N-myristoyltransferase

1989 • 56 citations

Membrane interactions of pp60v-src: a model for myristylated tyrosine protein kinases.

1990 • 54 citations

N myristoylation of the spleen necrosis virus matrix protein is required for correct association of the Gag polyprotein with intracellular membranes and for particle formation

1990 • 42 citations

Analysis of the compartmentalization of myristoyl-CoA:protein N-myristoyltransferase in Saccharomyces cerevisiae.

1992 • 39 citations

Analogs of palmitoyl-CoA that are substrates for myristoyl-CoA:protein N-myristoyltransferase.

1992 • 38 citations

Functional analysis of protein N-myristoylation: metabolic labeling studies using three oxygen-substituted analogs of myristic acid and cultured mammalian cells provide evidence for protein-sequence-specific incorporation and analog-specific redistribution.

1990 • 35 citations

Rat aldolaseA messenger RNA: the nucleotide sequence and multiple mRNA species with different 5′-terminal regions

1985 • 35 citations

High affinity binding of an N-terminal myristoylated p60 peptide

1989 • 34 citations

Novel fatty acyl substrates for myristoyl-CoA:protein N-myristoyl-transferase.

1990 • 33 citations

Myristylation Alters DNA-Binding Activity and Transactivation of FBR (gag-fos) Protein

1991 • 32 citations

Demonstration of multiple forms of bovine brain myristoyl CoA: protein N-myristoyl transferase

1992 • 32 citations

Characterisation of a Myristoyl CoA:Glycylpeptide N‐Myristoyl Transferase Activity in Rat Brain: Subcellular and Regional Distribution

1990 • 30 citations

The Myristylation Signal of p60^v-src Functionally Complements the N-Terminal fps-Specific Region of p130^gag-fps

1989 • 28 citations

Elevated N-myristoyl transferase activity is reversed by sodium orthovanadate in streptozotocin-induced diabetic rat

1993 • 20 citations

Characterization of N-myristoyl transferase inhibitors and their effect on HIV release

1991 • 20 citations

Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein.

1991 • 17 citations

The myristylation signal of p60v-src functionally complements the N-terminal fps-specific region of P130gag-fps.

1989 • 17 citations

Synthesis of myristoyl‐carba(dethia)‐coenzyme A and S‐(3‐oxohexadecyl)‐coenzyme A, two potent inhibitors of myristoyl‐CoA: protein N‐myristoyltransferase

1991 • 17 citations

Inhibitory Effect of Myristylation on Transrepression by FBR (Gag-Fos) Protein

1992 • 16 citations

Six amino acids from the retroviral gene gag greatly enhance the transforming potential of the oncogene v-erb-B.

1990 • 15 citations

Synthesis and characterization of inhibitors of myristoyl-CoA:Protein N-myristoyltransferase

1991 • 14 citations

Acylation of HIV proteins

1989 • 13 citations

12‐O‐Tetradecanoyl phorbol 13‐acetate stimulates the myristylation of an ∼ 82 kDa protein in HL‐60 cells

1987 • 13 citations

N‐Myristoyl‐transferase activity in cancer cells

1991 • 12 citations

IMMUNOGLOBULIN PRECURSORS: STRUCTURE, FUNCTION, GENE‐PROTEIN CORRELATION AND EVOLUTION*

1980 • 12 citations

Inhibitory effect of myristylation on transrepression by FBR (Gag-Fos) protein.

1992 • 12 citations

Bacterial expression, purification, andin vitro N-myristoylation of HIV-1 pl7gag

1992 • 9 citations

Blockage of morphological transformation of chick embryo fibroblasts infected with Rous sarcoma virus by N-myristoyl glycinal diethylacetal in vitro.

1989 • 7 citations

Protein myristoylation in human mononuclear phagocytes: modulation by interferon-y and tumor necrosis factor

1991 • 6 citations