4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

1988 • 1,634 citations

The molecular biology of the yeast saccharomyces: Metabolism and gene expression

1983 • 1,118 citations

Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1.

1989 • 831 citations

Infections withCryptococcus neoformansin the Acquired Immunodeficiency Syndrome

1989 • 792 citations

THE BIOLOGY AND ENZYMOLOGY OF EUKARYOTIC PROTEIN ACYLATION

1988 • 787 citations

Myristoylation-dependent replication and assembly of human immunodeficiency virus 1.

1990 • 634 citations

Cryptococcosis in the Acquired Immunodeficiency Syndrome

1985 • 628 citations

ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein

1991 • 604 citations

Myristylation of picornavirus capsid protein VP4 and its structural significance

1987 • 475 citations

n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle.

1982 • 395 citations

Fractionation of fats, oils, and waxes on thin layers of silicic acid

1960 • 394 citations

ADP-ribosylation factor is functionally and physically associated with the Golgi complex.

1990 • 372 citations

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

1987 • 365 citations

PHOSPHOLIPID BIOSYNTHESIS IN YEAST

1989 • 326 citations

Advances in Biotechnology

1981 • 325 citations

Identification of the NH₂‐terminal blocking group of calcineurin B as myristic acid

1982 • 312 citations

Myristylation site in Pr65gag is essential for virus particle formation by Moloney murine leukemia virus.

1986 • 300 citations

Protein N-myristoylation

1991 • 289 citations

DISTRIBUTION OF α AND α MATING TYPES OF CRYPTOCOCCUS NEOFORMANS AMONG NATURAL AND CLINICAL ISOLATES

1978 • 275 citations

ADP ribosylation factor is an essential protein in Saccharomyces cerevisiae and is encoded by two genes.

1990 • 257 citations

Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria.

1990 • 245 citations

Enzymatic determination of serum-free fatty acids: A colorimetric method

1980 • 244 citations

Myristylation is required for intracellular transport but not for assembly of D-type retrovirus capsids

1987 • 241 citations

Purification and characterization of yeast myristoyl CoA:protein N-myristoyltransferase.

1987 • 241 citations

A Novel Sequence Element Derived from Bacteriophage T7 mRNA Acts as an Enhancer of Translation of the lacZ Gene in Escherichia coli

1989 • 226 citations

Amino-terminal processing of proteins by N-myristoylation. Substrate specificity of N-myristoyl transferase.

1987 • 220 citations

A new HTLV-III/LAV Encoded Antigen Detected by Antibodies from AIDS Patients

1985 • 212 citations

Inhibition of Secretion of Hepatitis B Surface Antigen by a Related Presurface Polypeptide

1986 • 211 citations

A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole

1991 • 204 citations

Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins.

1988 • 204 citations

Isolation of the URA5 gene from Cryptococcus neoformans var. neoformans and its use as a selective marker for transformation.

1990 • 200 citations

Disruption of the Yeast N -Myristoyl Transferase Gene Causes Recessive Lethality

1989 • 190 citations

Myristoyl CoA:protein N-myristoyltransferase activities from rat liver and yeast possess overlapping yet distinct peptide substrate specificities.

1988 • 187 citations

Two systems of glucose repression of the GAL1 promoter in Saccharomyces cerevisiae.

1990 • 178 citations

Chemical and immunological characterization of the 21-kDa ADP-ribosylation factor of adenylate cyclase.

1988 • 175 citations

Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins.

1987 • 170 citations

The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid

1987 • 169 citations

On the Structure of Fatty Acid Synthetase of Yeast

1980 • 164 citations

Regulation of phospholipid biosynthesis in Saccharomyces cerevisiae by inositol. Inositol is an inhibitor of phosphatidylserine synthase activity.

1988 • 152 citations

Kinetic and structural evidence for a sequential ordered Bi Bi mechanism of catalysis by Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase

1991 • 144 citations

Mammalian reoviruses contain a myristoylated structural protein

1991 • 122 citations

Mutations in a gene encoding the alpha subunit of a Saccharomyces cerevisiae G protein indicate a role in mating pheromone signaling.

1988 • 121 citations

Lipid composition of 30 species of yeast

1976 • 120 citations

Myristic acid is coupled to a structural protein of polyoma virus and SV40

1987 • 108 citations

Capsid protein VP4 of poliovirus is N-myristoylated.

1987 • 107 citations

Improved one-dimensional thin-layer chromatographic technique for polar lipids

1985 • 96 citations

The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Analysis of myristic acid analogs containing oxygen, sulfur, double bonds, triple bonds, and/or an aromatic residue

1991 • 94 citations

Replication of human immunodeficiency virus 1 and Moloney murine leukemia virus is inhibited by different heteroatom-containing analogs of myristic acid.

1989 • 92 citations

Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase

1990 • 87 citations

Isolation of a Saccharomyces cerevisiae long chain fatty acyl:CoA synthetase gene (FAA1) and assessment of its role in protein N-myristoylation.

1992 • 86 citations

N-myristoylation is required for function of the pheromone-responsive G alpha protein of yeast: conditional activation of the pheromone response by a temperature-sensitive N-myristoyl transferase.

1991 • 83 citations

RECEPTOR-G PROTEIN SIGNALING IN YEAST

1991 • 82 citations

Fatty acid biosynthesis in yeast

1978 • 79 citations

Substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Analysis of fatty acid analogs containing carbonyl groups, nitrogen heteroatoms, and nitrogen heterocycles in an in vitro enzyme assay and subsequent identification of inhibitors of human immunodeficiency virus I replication.

1992 • 76 citations

Phosphorylation of yeast phosphatidylserine synthase in vivo and in vitro by cyclic AMP-dependent protein kinase.

1988 • 72 citations

Regulation by temperature of the chain length of fatty acids in yeast.

1979 • 72 citations

The Candida albicans myristoyl-CoA:protein N-myristoyltransferase gene. Isolation and expression in Saccharomyces cerevisiae and Escherichia coli.

1992 • 70 citations

Incorporation of 12-methoxydodecanoate into the human immunodeficiency virus 1 gag polyprotein precursor inhibits its proteolytic processing and virus production in a chronically infected human lymphoid cell line.

1991 • 70 citations

Structural and functional studies of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase produced in Escherichia coli. Evidence for an acyl-enzyme intermediate.

1990 • 68 citations

Myristic acid auxotrophy caused by mutation of S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase.

1991 • 68 citations

Analyzing the substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase by co-expressing it with mammalian G protein alpha subunits in Escherichia coli

1991 • 67 citations

The Genetics of Medically Important Fungi

1987 • 67 citations

Regulation of yeast phosphatidylserine synthase and phosphatidylinositol synthase activities by phospholipids in Triton X-100/phospholipid mixed micelles.

1990 • 60 citations

The critical micelle concentration of some physiologically important fatty acyl-coenzyme A's as a function of chain length

1986 • 58 citations

Myristoylation, Phosphorylation, and Subcellular Distribution of the 80-kDa Protein Kinase C Substrate in BC3H1 Myocytes

1989 • 55 citations

Substitution of cellular fatty acids in yeast cells by the antibiotic cerulenin and exogenous fatty acids

1975 • 52 citations

Regulation of eukaryotic phospholipid metabolism ¹

1991 • 51 citations

Yeast Mutants Defective in Acetyl‐Coenzyme A Carboxylase and Biotin: Apocarboxylase Ligase

1980 • 47 citations

Altered membrane association of p60v-src and a murine 63-kDa N-myristoyl protein after incorporation of an oxygen-substituted analog of myristic acid.

1989 • 44 citations

Fatty‐Acid Elongation in a Mutant of Saccharomyces cerevisiae Deficient in Fatty‐Acid Synthetase

1972 • 42 citations

Reconstitution of protein N-myristoylation in

1990 • 42 citations

Analysis of the compartmentalization of myristoyl-CoA:protein N-myristoyltransferase in Saccharomyces cerevisiae.

1992 • 39 citations

Systemic fungal infections: diagnosis and treatment. I. Therapeutic agents.

1988 • 38 citations

Functional analysis of protein N-myristoylation: metabolic labeling studies using three oxygen-substituted analogs of myristic acid and cultured mammalian cells provide evidence for protein-sequence-specific incorporation and analog-specific redistribution.

1990 • 35 citations

Possible Involvement of Acetyl Coenzyme A Carboxylase as Well as Fatty Acid Synthetase in the Temperature-Controlled Synthesis of Fatty Acids in Saccharomyces cerevisiae1

1987 • 31 citations

Genetic complementation in Cryptococcus neoformans

1986 • 25 citations

AIDS and the Mycoses

1988 • 22 citations

Therapeutic Agents

1988 • 21 citations

Synthesis of myristoyl‐carba(dethia)‐coenzyme A and S‐(3‐oxohexadecyl)‐coenzyme A, two potent inhibitors of myristoyl‐CoA: protein N‐myristoyltransferase

1991 • 17 citations

Analysis of Fatty Acids of Continuously Cultured Mammalian Cells by Gas-Liquid Chromatography

1962 • 17 citations

Antifungal Properties of n-Alkoxyacetic Acids and Their Methyl Esters

1979 • 14 citations

Synthesis and characterization of inhibitors of myristoyl-CoA:Protein N-myristoyltransferase

1991 • 14 citations

Lipids of Candida albicans: subcellular distribution and biosynthesis

1990 • 13 citations

N‐Myristoyl‐transferase activity in cancer cells

1991 • 12 citations

Sterol and phospholipid acyl chain alterations inSaccharomyces cerevisiae secretion mutants as a function of temperature stress

1987 • 8 citations