Development of autoimmune exocrinopathy resembling Sjögren's syndrome in adoptively transferred mice with autoreactive CD4+ T cells

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

1999 • 426 citations

Identification of α-Fodrin as a Candidate Autoantigen in Primary Sjögren's Syndrome

1997 • 400 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.

1991 • 322 citations

Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands

1997 • 253 citations

Anti-α-fodrin inhibits secretion from permeabilized chromaffin cells

1987 • 184 citations

Differential Tolerance Is Induced in T Cells Recognizing Distinct Epitopes of Myelin Basic Protein

1998 • 182 citations

T-Cell Responses to Autoantigens in IDDM: The Search for the Holy Grail

1996 • 164 citations

Spontaneous development of autoimmune thyroiditis in neonatally thymectomized mice.

1976 • 148 citations

T cell receptor repertoire of infiltrating T cells in lips of Sjögren's syndrome patients.

1992 • 133 citations

Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function.

1996 • 121 citations

A new animal model for primary Sjögren's syndrome in NFS/sld mutant mice.

1994 • 117 citations

Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin.

1990 • 109 citations

Fas Ligand-Mediated Exocrinopathy Resembling Sjögren’s Syndrome in Mice Transgenic for IL-10

1999 • 105 citations

A New Look at MHC and Autoimmune Disease

1999 • 105 citations

cAMP and Ca(2+)-mediated secretion in parotid acinar cells is associated with reversible changes in the organization of the cytoskeleton.

1992 • 97 citations

Restricted heterogeneity in T-cell antigen receptor V beta gene usage in the lymph nodes and arthritic joints of mice.

1992 • 88 citations

Critical self-epitopes are key to the understanding of self-tolerance and autoimmunity

1999 • 85 citations

Molecular Basis for Recognition of an Arthritic Peptide and a Foreign Epitope on Distinct MHC Molecules by a Single TCR

2000 • 81 citations

Pathogenesis of post-thymectomy autoimmunity. Role of syngeneic MLR-reactive T cells.

1995 • 77 citations

Induction of peripheral CD8⁺ T‐cell tolerance by cross‐presentation of self antigens

1998 • 76 citations

Induction of Experimental Autoallergic Sialadenitis

1974 • 73 citations

Human self-reactive T cell clones expressing identical T cell receptor beta chains differ in their ability to recognize a cryptic self-epitope.

1996 • 67 citations

Prevention and Induction of Autoimmune Exocrinopathy Is Dependent on Pathogenic Autoantigen Cleavage in Murine Sjögren’s Syndrome

2002 • 60 citations

Role of viruses in type I diabetes

1998 • 60 citations

Anti-120-kDa α-fodrin immune response with Th1-cytokine profile in the NOD mouse model of Sjögren's syndrome

1998 • 53 citations

The role of CD4 and CD8 T cells in type I diabetes in the NOD mouse

1997 • 49 citations

CD4+ and CD8+ T lymphocytes: Clarification of their pathogenic roles in diabetes in the NOD mouse

1997 • 43 citations

A new mutation involving the sublingual gland in NFS/N mice. Partially arrested mucous cell differentiation.

1988 • 34 citations

Protective and destructive effects of microbial infection in insulin-dependent diabetes mellitus

1998 • 26 citations

The immune response to islets in experimental diabetes and insulin-dependent diabetes mellitus

1996 • 25 citations

Autoantigen-Specific CD4+CD28low T Cell Subset Prevents Autoimmune Exocrinopathy in Murine Sjögren’s Syndrome

2000 • 17 citations

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