Phenotype and function of human T lymphocyte subsets: Consensus and issues

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Phenotypic and functional features of human Th17 cells

2007 • 1,832 citations

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

2006 • 1,802 citations

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

2007 • 1,773 citations

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

2002 • 1,583 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

T-cell quality in memory and protection: implications for vaccine design

2008 • 1,499 citations

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

1997 • 1,391 citations

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

2007 • 1,346 citations

Skewed maturation of memory HIV-specific CD8 T lymphocytes

2001 • 1,025 citations

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

2003 • 999 citations

Molecular and Functional Profiling of Memory CD8 T Cell Differentiation

2002 • 962 citations

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

2005 • 916 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

2008 • 792 citations

Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

2007 • 700 citations

Characterization of CD4+ CTLs Ex Vivo

2002 • 535 citations

Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses

2007 • 487 citations

Development and Homeostasis of T Cell Memory in Rhesus Macaque

2002 • 475 citations

Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection

2004 • 457 citations

11-color, 13-parameter flow cytometry: Identification of human naive T cells by phenotype, function, and T-cell receptor diversity

2001 • 452 citations

Primary immune responses to human CMV: a critical role for IFN-γ–producing CD4+ T cells in protection against CMV disease

2003 • 421 citations

Innate and adaptive lymphoid cells in the human liver

2000 • 396 citations

Four Functionally Distinct Populations of Human Effector-Memory CD8+ T Lymphocytes

2007 • 385 citations

Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1–infected subjects with progressive disease: changes after antiretroviral therapy

2003 • 380 citations

Cell Sorting: Automated Separation of Mammalian Cells as a Function of Intracellular Fluorescence

1969 • 376 citations

Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells

1999 • 367 citations

Emergence of a CD4+CD28− Granzyme B+, Cytomegalovirus-Specific T Cell Subset after Recovery of Primary Cytomegalovirus Infection

2004 • 354 citations

Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)

2002 • 326 citations

A Single Naive CD8+ T Cell Precursor Can Develop into Diverse Effector and Memory Subsets

2007 • 323 citations

HIV-1-specific IFN-γ/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells

2005 • 310 citations

Cytomegalovirus-Specific CD4+ T Cells in Healthy Carriers Are Continuously Driven to Replicative Exhaustion

2005 • 292 citations

Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells

2004 • 289 citations

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

2003 • 279 citations

Cutting Edge: Cytolytic Effector Function in Human Circulating CD8+ T Cells Closely Correlates with CD56 Surface Expression

2000 • 263 citations

Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts.

1996 • 259 citations

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

2003 • 252 citations

Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNγ-Mediated B Cell Depletion

2001 • 237 citations

Polyfunctional T cell responses are a hallmark of HIV‐2 infection

2008 • 235 citations

Characterization of the CD4+ T Cell Response to Epstein-Barr Virus during Primary and Persistent Infection

2003 • 226 citations

Differentiation of Human CD8+ T Cells from a Memory to Memory/Effector Phenotype

2002 • 224 citations

Identification of Naive or Antigen-Experienced Human CD8+ T Cells by Expression of Costimulation and Chemokine Receptors: Analysis of the Human Cytomegalovirus-Specific CD8+ T Cell Response

2002 • 216 citations

L-selectin-negative CCR7− effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells

2007 • 201 citations

Expression of the Murine CD27 Ligand CD70 In Vitro and In Vivo

2003 • 193 citations

Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions

2003 • 191 citations

Expression and function of NK cell receptors in CD8+ T cells

2001 • 177 citations

Memory T Cells Constitute a Subset of the Human CD8+CD45RA+ Pool with Distinct Phenotypic and Migratory Characteristics

2001 • 174 citations

PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status

2007 • 169 citations

Differential expression of human granzymes A, B, and K in natural killer cells and during CD8⁺ T cell differentiation in peripheral blood

2005 • 168 citations

IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro

2003 • 164 citations

Increased Expression of the NK Cell Receptor KLRG1 by Virus-Specific CD8 T Cells during Persistent Antigen Stimulation

2005 • 162 citations

IL-7 receptor α chain expression distinguishes functional subsets of virus-specific human CD8+ T cells

2005 • 162 citations

Three Memory Subsets of Human CD8+ T Cells Differently Expressing Three Cytolytic Effector Molecules

2006 • 160 citations

The Size and Phenotype of Virus-Specific T Cell Populations Is Determined by Repetitive Antigenic Stimulation and Environmental Cytokines

2004 • 121 citations

Repertoire, diversity, and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus disease

2005 • 118 citations

Functional Expression of the Chemokine Receptor CCR5 on Virus Epitope-Specific Memory and Effector CD8+ T Cells

2002 • 110 citations

CD11b expression as a marker to distinguish between recently activated effector CD8+ T cells and memory cells

2001 • 98 citations

Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMV

2005 • 94 citations

The Activatory Receptor 2B4 Is Expressed In Vivo by Human CD8+ Effector αβ T Cells

2001 • 94 citations

HIV-1-Specific Memory CD4+ T Cells Are Phenotypically Less Mature Than Cytomegalovirus-Specific Memory CD4+ T Cells

2004 • 88 citations

Cytolytic Mechanisms and Expression of Activation-Regulating Receptors on Effector-Type CD8+CD45RA+CD27− Human T Cells

2000 • 77 citations

Flow cytometric detection of perforin upregulation in human CD8 T cells

2008 • 76 citations

Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells

2004 • 69 citations

Antigen Burden Is a Major Determinant of Human Immunodeficiency Virus–Specific CD8⁺T Cell Maturation State: Potential Implications for Therapeutic Immunization

2003 • 65 citations

Analysis of the Frequencies and of the Memory T Cell Phenotypes of Human CD8⁺T Cells Specific for Influenza A Viruses

2003 • 64 citations

Virus-Specific Cellular Immune Correlates of Survival in Vaccinated Monkeys after Simian Immunodeficiency Virus Challenge

2006 • 64 citations

Techniques to improve the direct ex vivo detection of low frequency antigen‐specific CD8⁺ T cells with peptide‐major histocompatibility complex class I tetramers

2008 • 55 citations

The chemokine receptor CX3CR1 controls homing and anti-viral potencies of CD8 effector-memory T lymphocytes in HIV-infected patients

2003 • 53 citations

Sensitive Gene Expression Profiling of Human T Cell Subsets Reveals Parallel Post-Thymic Differentiation for CD4+ and CD8+ Lineages

2007 • 41 citations

The influence of different stimulation conditions on the assessment of antigen‐induced CD154 expression on CD4⁺ T cells

2008 • 40 citations

How flow cytometry is changing the study of TB immunology and clinical diagnosis

2008 • 39 citations

Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation

2005 • 37 citations

Use of MHC class II tetramers to investigate CD4⁺ T cell responses: Problems and solutions

2008 • 36 citations

Functional and phenotypic analysis of human memory CD8+ T cells expressing CXCR3

2006 • 32 citations

FATT‐CTL assay for detection of antigen‐specific cell‐mediated cytotoxicity

2008 • 19 citations