Ubiquitin, cell stress and diseases of the nervous system

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

The Neuron-Specific Protein PGP 9.5 Is a Ubiquitin Carboxyl-Terminal Hydrolase

1989 • 864 citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1987 • 850 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.

1975 • 691 citations

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

1987 • 606 citations

Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease

1988 • 541 citations

Stress proteins, infection, and immune surveillance

1989 • 477 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

Stress proteins are immune targets in leprosy and tuberculosis.

1988 • 446 citations

Ubiquitin-Mediated Pathways for Intracellular Proteolysis

1987 • 409 citations

Lewy bodies are ubiquitinated

1988 • 392 citations

Ubiquitin is a heat shock protein in chicken embryo fibroblasts.

1985 • 392 citations

The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences.

1985 • 355 citations

Ubiquitin carboxyl‐terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases

1990 • 351 citations

Heat shock and the heat shock proteins

1986 • 336 citations

Ubiquitin deposits in anterior horn cells in motor neurone disease

1988 • 277 citations

Alz-50, Ubiquitin and Tau Immunoreactivity of Neurofibrillary Tangles, Pick Bodies and Lewy Bodies

1988 • 238 citations

Effect of heat shock on protein degradation in mammalian cells: involvement of the ubiquitin system.

1987 • 235 citations

A filamentous inclusion body within anterior horn neurones in motor neurone disease defined by immunocytochemical localisation of ubiquitin

1988 • 226 citations

Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease.

1989 • 195 citations

Structure and expression of ubiquitin genes of Drosophila melanogaster.

1988 • 185 citations

Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry.

1989 • 184 citations

Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase

1988 • 179 citations

The Chicken Ubiquitin Gene Contains a Heat Shock Promoter and Expresses an Unstable mRNA in Heat-Shocked Cells

1986 • 137 citations

Stress-induced proteins

1988 • 100 citations

Ubiquitin is present on the cytokeratin intermediate filaments and Mallory bodies of hepatocytes.

1988 • 99 citations

Ubiquitin-protein conjugates in Alzheimer's lesions

1987 • 97 citations

The chicken ubiquitin gene contains a heat shock promoter and expresses an unstable mRNA in heat-shocked cells.

1986 • 94 citations

Ubiquitin-protein conjugates accumulate in the lysosomal system of fibroblasts treated with cysteine proteinase inhibitors

1989 • 91 citations

Selective presence of ubiquitin in intracellular inclusions.

1989 • 88 citations

Small heat shock proteins of Drosophila associate with the cytoskeleton.

1986 • 88 citations

Ubiquitin gene expression in Dictyostelium is induced by heat and cold shock, cadmium, and inhibitors of protein synthesis

1988 • 83 citations

Lewy body-like hyaline inclusions in sporadic motor neuron disease are ubiquitinated

1989 • 80 citations

Ubiquitin is a component of neurofibrillary tangles in a variety of neurodegenerative diseases

1988 • 77 citations

Isolation of a major protein component of Rosenthal fibers.

1988 • 68 citations

Ubiquitin

1988 • 55 citations

Ubiquitin conjugate immunoreactivity in the brains of scrapie infected mice

1990 • 45 citations

Ubiquitin/ATP-Dependent Protease

1988 • 33 citations

ROSENTHAL FIBRES ARE BASED ON THE UBIQUITINATION OF GLIAL FILAMENTS

1989 • 27 citations

Intermediate filament-ubiquitin diseases: implications for cell sanitization.

1989 • 27 citations

Ubiquitin gene expression in brain and spinal cord in motor neurone disease

1989 • 25 citations

Heterogeneity of ubiquitin immunoreactivity in neurofibrillary tangles of Alzheimer's disease

1989 • 19 citations