[1] Isolation and utilization of epidermal keratinocytes for oncogene research

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

1975 • 4,443 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Calcium regulation of growth and differentiation of mouse epidermal cells in culture

1980 • 1,810 citations

Calcium-Regulated Differentiation of Normal Human Epidermal Keratinocytes in Chemically Defined Clonal Culture and Serum-Free Serial Culture

1983 • 1,088 citations

Physiology, Biochemistry, and Molecular Biology of the Skin

1992 • 791 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro.

1989 • 569 citations

Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA

1987 • 533 citations

The Reconstitution of Living Skin

1983 • 499 citations

Physiology, biochemistry, and molecular biology of the skin

1991 • 434 citations

Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA.

1987 • 417 citations

Epstein–Barr virus latent membrane protein inhibits human epithelial cell differentiation

1990 • 377 citations

Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18

1990 • 319 citations

Defective terminal differentiation in culture as a consistent and selectable character of malignant human keratinocytes

1980 • 319 citations

Morphological transformation of human keratinocytes expressing the LMP gene of Epstein Barr virus

1990 • 299 citations

Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma.

1988 • 259 citations

The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis--thirty-third G. H. A. Clowes Memorial Award Lecture.

1994 • 248 citations

Correlation of anchorage-independent growth with tumorigenicity of chemically transformed mouse epidermal cells.

1978 • 243 citations

Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.

1993 • 240 citations

BALB and kirsten murine sarcoma viruses alter growth and differentiation of EGF-dependent BALB/c mouse epidermal keratinocyte lines

1983 • 224 citations

Neoplastic Transformation of Human Epidermal Keratinocytes by AD12-SV40 and Kirsten Sarcoma Viruses

1985 • 223 citations

An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

1986 • 218 citations

c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy.

1990 • 212 citations

Reconstitution of Hair Follicle Development In Vivo: Determination of Follicle Formation, Hair Growth, and Hair Quality by Dermal Cells

1993 • 212 citations

Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.

1993 • 207 citations

The E6 and E7 genes of HPV-18 are sufficient for inducing two-stage in vitro transformation of human keratinocytes.

1989 • 194 citations

Characterization of primary human keratinocytes transformed by human papillomavirus type 18

1988 • 192 citations

Production of human papillomavirus and modulation of the infectious program in epithelial raft cultures. OFF.

1992 • 188 citations

Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies.

1984 • 186 citations

Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts.

1988 • 183 citations

Effects of SV40 transformation on the cytoskeleton and behavioural properties of human keratinocytes

1982 • 165 citations

Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA

1988 • 147 citations

Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter in Vitro and in Transgenic Mice

1993 • 134 citations

Epithelial-mesenchymal interactions control basement membrane production and differentiation in cultured and transplanted mouse keratinocytes

1986 • 129 citations

The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis.

1993 • 114 citations

Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses

1985 • 112 citations

Human cervical and foreskin epithelial cells immortalized by human papillomavirus DNAs exhibit dysplastic differentiation in vivo.

1990 • 110 citations

Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.

1992 • 107 citations

Differentiation of human epidermal cells transformed by SV40.

1983 • 107 citations

Comparison of Methods for Transfection of Human Epidermal Keratinocytes

1991 • 98 citations

Altered Regulation of TGF‐β1 and TGF‐α in Primary Keratinocytes and Papillomas Expressing v‐Ha‐ras

1991 • 94 citations

Clonal Growth of Mouse Epidermal Cells in Medium with Reduced Calcium Concentration

1981 • 82 citations

Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice.

1993 • 77 citations

Extracellular matrix receptors and mouse skin carcinogenesis: altered expression linked to appearance of early markers of tumor progression.

1992 • 76 citations

A subpopulation of cultured human keratinocytes which is resistant to the induction of terminal differentiation-related changes by phorbol, 12-myristate, 13-acetate: evidence for an increase in the resistant population following transformation

1983 • 75 citations

Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations.

1992 • 74 citations

Retrovirus-Mediated Transduction of Cultured Epidermal Keratinocytes

1991 • 74 citations

Mouse epidermal keratinocytes

1984 • 73 citations

Characteristics of chemically transformed mouse epidermal cells in vitro and in vivo.

1978 • 72 citations

Recombinant retroviruses encoding human papillomavirus type 18 E6 and E7 genes stimulate proliferation and delay differentiation of human keratinocytes early after infection.

1992 • 71 citations

TGFα stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression

1988 • 70 citations

Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.

1993 • 68 citations

The v‐ras oncogene inhibits the expression of differentiation markers and facilitates expression of cytokeratins 8 and 18 in mouse keratinocytes

1990 • 67 citations

Relative resistance to 1,25-dihydroxyvitamin D3 in a keratinocyte model of tumor progression.

1992 • 65 citations

Identification of control elements 3' to the human keratin 1 gene that regulate cell type and differentiation-specific expression.

1993 • 63 citations

Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene

1988 • 59 citations

Aberrant expression of the simple epithelial type II keratin 8 by mouse skin carcinomas but not papillomas

1992 • 58 citations

Overexpression of wild-type p53 alters growth and differentiation of normal human keratinocytes but not human papillomavirus-expressing cell lines.

1993 • 57 citations

Neoplastic Transformation of Immortalized Human Epidermal Keratinocytes by Two HHV-6 DNA Clones

1993 • 56 citations

Mouse differentiation-specific keratins 1 and 10 require a preexisting keratin scaffold to form a filament network.

1993 • 56 citations

Simple epithelial nature of some simian virus-40-transformed human epidermal keratinocytes.

1984 • 54 citations

Sequential development of aneuploidy, keratin modifications, and gamma-glutamyltransferase expression in mouse skin papillomas.

1988 • 53 citations

Altered regulation of growth and expression of differentiation-associated keratins in benign mouse skin tumors

1991 • 50 citations

Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia.

1993 • 49 citations

Interactions of growth factors and retroviral oncogenes with mitogenic signal transduction pathways of Balb/MK keratinocytes.

1988 • 49 citations

Cotransfection of HPV-18 and v-fos DNA Induces Tumorigenicity of Primary Human Keratinocytes

1993 • 48 citations

Transfection of the EJ ras^Ha Gene into Keratinocytes Derived from Carcinogen-Induced Mouse Papillomas Causes Malignant Progression

1986 • 47 citations

Sequential combined tumorigenic effect of HPV-16 and chemical carcinogens

1992 • 46 citations

DNA-mediated gene transfer into epidermal cells using electroporation

1986 • 43 citations

Transfection of the EJ rasHa gene into keratinocytes derived from carcinogen-induced mouse papillomas causes malignant progression.

1986 • 41 citations

Reconstituted skin in culture:a simple method with optimal differentiation

1990 • 40 citations

The HIV tat gene transforms human keratinocytes.

1992 • 39 citations

Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation.

1993 • 30 citations

A new medium for primary cultures of adult murine epidermal cells: Application to experimental carcinogenesis☆

1987 • 29 citations

Two strains of human keratinocytes transfected with HPV16 DNA: comparison with the normal parental cells

1991 • 28 citations

Expression of Transfected DNA by Primary Murine Keratinocytes

1988 • 27 citations

Neoplastic transformation of human keratinocytes by polybrene-induced DNA-mediated transfer of an activated oncogene.

1989 • 26 citations

Inhibition of tumor formation from grafted murine papilloma cells by treatment of grafts with staurosporine, an inducer of squamous differentiation

1993 • 26 citations

Malignant human papillomavirus type 16-transformed human keratinocytes exhibit altered expression of extracellular matrix glycoproteins.

1991 • 24 citations

Transient Expression of a Transfected Gene in Cultured Epidermal Keratinocytes: Implications for Future Studies

1989 • 24 citations

Magnesium and phosphate enrichment of culture medium stimulates the proliferation of epidermal cells from newborn and adult mice

1990 • 23 citations

Immortalization of human keratinocytes by simian virus 40 large T-antigen alters keratin gene response to retinoids.

1990 • 23 citations

Malignant progression of papilloma‐derived keratinocytes: Differential effects of the ras, neu, and p⁵³ oncogenes

1988 • 19 citations

Retention of differentiated characteristics in human fetal keratinocytes in vitro

1989 • 18 citations

Malignant transformation of a preneoplastic hamster epidermal cell line by the EJ c-Ha-ras-oncogene.

1986 • 18 citations

Specific effects of ras oncogene expression on the growth and histogenesis of human epidermal keratinocytes.

1990 • 16 citations

Different levels of v‐Ha‐ras p21 expression in primary keratinocytes transformed with harvey sarcoma virus correlate with benign versus malignant behavior

1993 • 15 citations

Transient expression of the cloned mouse c‐Ha‐ras 5′ upstream region in transfected primary SENCAR mouse keratinocytes demonstrates its power as a promoter element

1991 • 14 citations

A comparison of interfollicular and hair follicle derived cells as targets for the v-ras^Ha oncogene in mouse skin carcinogenesis

1991 • 14 citations

A keratin of fetal skin is reexpressed in human keratinocytes transformed by SV40 virus or treated with the tumor promoter TPA

1984 • 13 citations

Epithelium-specific Response of Cultured Keratinocytes to Infection with Adenovirus Type 2

1988 • 13 citations

Neoplastic transformation of a human keratinocyte cell line by the v-fos oncogene.

1993 • 12 citations

Skin Carcinogenesis in Man and in Experimental Models

1993 • 9 citations

Immortalization of rat keratinocytes by transfection with polyomavirus large T gene

1988 • 9 citations

Bovine Papillomavirus Type I Induces Resistance to Ca⁺⁺-Induced Terminal Differentiation in Murine Keratinocytes

1989 • 8 citations

Induction in hamsters of various carcinomas and sarcomas by in-vitro SV40-transformed homologous embryonic skin and subcutaneous tissue cells. Role of target cells in determining tumor morphology.

1969 • 6 citations

In vivo and in vitro effects of v-fos and EJ-Ha-ras oncogene expression in murine epidermal keratinocytes.

1989 • 3 citations

Growth advantage by overexpression of normal Harvey ras proto-oncogene in cultured rat epidermal keratinocytes

1990 • 1 citations