A Molecular Framework for Two-Step T Cell Signaling: Lck Src Homology 3 Mutations Discriminate Distinctly Regulated Lipid Raft Reorganization Events

Functional rafts in cell membranes

1997 • 9,471 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

LAT Palmitoylation

1998 • 837 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

A detergent-free method for purifying caveolae membrane from tissue culture cells.

1995 • 732 citations

A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts

1998 • 708 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

1990 • 360 citations

Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains.

1996 • 312 citations

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

1994 • 299 citations

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

1991 • 284 citations

Engagement of GPI-Linked CD48 Contributes to TCR Signals and Cytoskeletal Reorganization

1998 • 278 citations

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

1993 • 221 citations

The Actin Cytoskeleton and Lymphocyte Activation

1999 • 218 citations

A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

2000 • 203 citations

Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation

1999 • 180 citations

Integrin Leukocyte Function-associated Antigen-1-mediated Cell Binding Can Be Activated by Clustering of Membrane Rafts

1999 • 178 citations

Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions.

1995 • 163 citations

Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts

2000 • 158 citations

The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src

1997 • 144 citations

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

1993 • 142 citations

CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection

2000 • 137 citations

Topology of the CD2–CD48 cell-adhesion molecule complex: implications for antigen recognition by T cells

1995 • 124 citations

Regulation of Protein Kinase Cθ Function during T Cell Activation by Lck-mediated Tyrosine Phosphorylation

2000 • 118 citations

Noncovalent associations of T lymphocyte surface proteins

1996 • 111 citations

Strong TCR Ligation Without Costimulation Causes Rapid Onset of Fas-Dependent Apoptosis of Naive Murine CD4+ T Cells

1999 • 109 citations

Interaction between Sam68 and Src Family Tyrosine Kinases, Fyn and Lck, in T Cell Receptor Signaling

1997 • 103 citations

CD48-deficient mice have a pronounced defect in CD4⁺T cell activation

1999 • 96 citations

Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.

1992 • 91 citations

The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2.

1996 • 84 citations

LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck.

1995 • 80 citations

The Ras GTPase-activating Protein (GAP) Is an SH3 Domain-binding Protein and Substrate for the Src-related Tyrosine Kinase, Hck

1995 • 79 citations

Selective Induction of Apoptosis in Mature T Lymphocytes by Variant T Cell Receptor Ligands

1998 • 72 citations

The regulation of antigen-receptor signaling by protein tyrosine phosphatases: a hole in the story

1999 • 58 citations

The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the zeta-chain and IL-2 production.

1997 • 57 citations

The Lck SH3 Domain Is Required for Activation of the Mitogen-activated Protein Kinase Pathway but Not the Initiation of T-cell Antigen Receptor Signaling

1999 • 57 citations

Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation

2000 • 51 citations

The SH2 Domain is Required for Stable Phosphorylation of p56^1ck at Tyrosine 505, the Negative Regulatory Site

1993 • 44 citations

The Kinase, SH3, and SH2 Domains of Lck Play Critical Roles in T-Cell Activation after ZAP-70 Membrane Localization

1996 • 42 citations

Ceramide-independent CD28 and TCR signaling but reduced IL-2 secretion in T cells of acid sphingomyelinase-deficient mice

1998 • 40 citations

Diurnal Periodicity in Epiphyseal Growth Cartilage

1962 • 34 citations

Association between Mitogen-activated Protein Kinase and the ζ Chain of the T Cell Receptor (TcR) with the SH2,3 Domain of p56lck

1996 • 30 citations

Phosphatidylinositol (PI) 3-Kinase and PI 4-Kinase Binding to the CD4-p56^lck Complex: the p56^lck SH3 Domain Binds to PI 3-Kinase but Not PI 4-Kinase

1993 • 27 citations

Structural Requirements for Enhancement of T-Cell Responsiveness by the Lymphocyte-Specific Tyrosine Protein Kinase p56^lck

1992 • 25 citations

The Protein-tyrosine Kinase Lck Associates with and Is Phosphorylated by Cdc2

1996 • 24 citations

T cell antigen receptor-induced IL-2 production and apoptosis have different requirements for Lck activities.

1997 • 20 citations

News and Views

1997 • 2 citations