Coexpression of flt-3 ligand/flt-3 and SCF/c-kit signal transduction system in bile-duct-ligated SI and W mice.

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

1991 • 606 citations

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.

1990 • 599 citations

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

1995 • 596 citations

Molecular cloning of a ligand for the flt3flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells

1993 • 546 citations

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

1989 • 495 citations

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

1994 • 459 citations

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

1994 • 453 citations

A precursor—product relationship exists between oval cells and hepatocytes in rat liver

1987 • 448 citations

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis

1993 • 355 citations

Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development.

1991 • 346 citations

Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells

1994 • 319 citations

Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

1991 • 309 citations

Is there a liver stem cell?

1990 • 304 citations

Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family.

1991 • 300 citations

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.

1991 • 300 citations

Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci

1991 • 292 citations

Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.

1994 • 285 citations

Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway

1995 • 280 citations

Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form

1995 • 268 citations

Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors

1995 • 240 citations

Flt3 ligand induces proliferation of quiescent human bone marrow CD34+CD38- cells and maintains progenitor cells in vitro

1996 • 240 citations

Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat

1990 • 227 citations

Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells.

1993 • 174 citations

Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse.

1994 • 168 citations

The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro

1996 • 147 citations

Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs.

1995 • 98 citations

Coexpression of Stem Cell Factor andc-kitin Embryonic and Adult Liver

1996 • 75 citations

Models for Hepatic Progenitor Cell Activation

1993 • 68 citations

A quantitative assessment of the structural changes the rat's liver following obstruction of the common bile duct.

1976 • 59 citations

A role for stem cell factor and c-kit in the murine intestinal tract secretory response to cholera toxin.

1995 • 46 citations

Mitogenic Signalling and Substrate Specificity of the Flk2/Flt3 Receptor Tyrosine Kinase in Fibroblasts and Interleukin 3-Dependent Hematopoietic Cells

1993 • 40 citations

Failure of W/Wv mouse-derived cultured mast cells to enter S phase upon contact with NIH/3T3 fibroblasts

1988 • 34 citations

Analysis of the mitogenic pathway of the FLT3 receptor and characterization in its C terminal region of a specific binding site for the PI3' kinase.

1994 • 15 citations