Activation of human platelet-derived latent transforming growth factor-β1 by human glioblastoma cells. Comparison with proteolytic and glycosidic enzymes

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences

1990 • 447 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.

1989 • 391 citations

Transforming growth factors and the regulation of cell proliferation

1990 • 390 citations

Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.

1987 • 387 citations

Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2-mediated effects.

1984 • 367 citations

Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions

1985 • 366 citations

Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines.

1985 • 344 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.

1987 • 337 citations

Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

1989 • 281 citations

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.

1988 • 273 citations

Role for carbohydrate structures inTGF-β1 latency

1989 • 270 citations

Production of transforming growth factor beta by human peripheral blood monocytes and neutrophils

1989 • 260 citations

β-Transforming Growth Factor is stored in human blood platelets as a latent high molecular weight complex

1986 • 241 citations

Type 1 Transforming Growth Factor Beta: Amplified Expression and Secretion of Mature and Precursor Polypeptides in Chinese Hamster Ovary Cells

1987 • 224 citations

Site-directed Mutagenesis of Cysteine Residues in the Pro Region of the Transforming Growth Factor β1 Precursor

1989 • 220 citations

Specific binding to cultured cells of 125I-labeled type beta transforming growth factor from human platelets.

1984 • 212 citations

Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor.

1988 • 211 citations

Human transforming growth factor beta.alpha 2-macroglobulin complex is a latent form of transforming growth factor beta.

1988 • 209 citations

The pro domain of pre-pro-transforming growth factor .beta.1 when independently expressed is a functional binding protein for the mature growth factor

1990 • 185 citations

The autocrine production of transforming growth factor-beta 1 during lymphocyte activation. A study with a monoclonal antibody-based ELISA.

1990 • 169 citations

Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice.

1989 • 164 citations

Differential inhibition of transforming growth factor beta 1 and beta 2 activity by alpha 2-macroglobulin.

1990 • 148 citations

Interactions of recombinant and platelet transforming growth factor-β1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor

1989 • 127 citations

The glioblastoma‐derived t cell suppressor factor/ transforming growth factor‐β2 inhibits t cell growth without affecting the interaction of interleukin 2 with its receptor

1988 • 123 citations

Recombinant TGF-β1 is Synthesized as a Two-Component Latent Complex that Shares Some Structural Features with the Native Platelet Latent TGF-β1 Complex

1989 • 108 citations

Molecular Events in the Processing of Recombinant Type 1 Pre-Pro-Transforming Growth Factor Beta to the Mature Polypeptide

1988 • 78 citations

Acidic cellular environments: Activation of latent tgf‐β and sensitization of cellular responses to tgf‐β and egf

1989 • 69 citations

Transforming Growth Factor β1: Importance of Glycosylaytion and Acidic Proteases for Processing and Secretion

1989 • 64 citations

Alpha 2-macroglobulin and serum preferentially counteract the mitoinhibitory effect of transforming growth factor-beta 2 in rat hepatocytes.

1990 • 64 citations

A new spectrophotometric method for the determination of chymotrypsin activity

1962 • 55 citations

Recombinant Type 1 Transforming Growth Factor β Precursor Produced in Chinese Hamster Ovary Cells Is Glycosylated and Phosphorylated

1988 • 53 citations

Purification and Structural Analysis of a Latent Form of Transforming Growth Factor-β from Rat Platelets1

1989 • 50 citations

[28] Enzymatic deglycosylation of glycoproteins

1987 • 49 citations

Heterogeneity of Latent Transforming Growth Factor-β Isolated from Bone Matrix Proteins*

1990 • 47 citations

Characterization of four human malignant glioma cell lines

1985 • 40 citations

The Action of Trypsin on Synthetic Chromogenic Arginine Substrates

1979 • 30 citations

Expression and Characterization of Recombinant TGF-β2 Proteins Produced in Mammalian Cells

1989 • 25 citations

Latent form of transforming growth factor-β1 acts as a potent growth inhibitor on a human erythroleukemia cell line

1990 • 22 citations

The growth inhibitor of African green monkey (BSC-1) cells is transforming growth factors .beta.1 and .beta.2

1989 • 19 citations

Transient production and secretion of human transforming growth factor TGF-β2

1989 • 17 citations

The significance of the n‐acyl residue of L‐alanyl‐L‐alanyl‐L‐alanine p‐nitroanilide for cleavage by pancreatic elastase

1974 • 7 citations