Ser‐262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

The distribution of tau in the mammalian central nervous system.

1985 • 1,518 citations

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

1992 • 936 citations

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

1984 • 852 citations

MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

1997 • 836 citations

[1] Assays of protein kinase

1983 • 832 citations

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

1993 • 759 citations

The Subunit Structure of Rabbit‐Skeletal‐Muscle Phosphorylase Kinase, and the Molecular Basis of Its Activation Reactions

1973 • 727 citations

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

1990 • 630 citations

Microtubule-Associated Proteins: Their Potential Role in Determining Neuronal Morphology

1988 • 599 citations

Tau protein binds to microtubules through a flexible array of distributed weak sites.

1991 • 540 citations

Microtubule organization and dynamics dependent on microtubule-associated proteins

1994 • 411 citations

Microtubule-associated Protein/Microtubule Affinity-regulating Kinase (p110mark)

1995 • 361 citations

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

1995 • 345 citations

Brain Levels of Microtubule‐Associated Protein τ Are Elevated in Alzheimer's Disease: A Radioimmuno‐Slot‐Blot Assay for Nanograms of the Protein

1992 • 289 citations

Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids.

1987 • 264 citations

Dephosphorylation of Alzheimer Paired Helical Filaments by Protein Phosphatase-2A and −2B

1995 • 264 citations

τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ

1993 • 228 citations

Ca2+/Calmodulin-dependent Protein Kinase Enriched in Cerebellar Granule Cells

1989 • 201 citations

Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly.

1993 • 198 citations

Recognition of the minimal epitope of monoclonal antibody Tau‐1 depends upon the presence of a phosphate group but not its location

1993 • 190 citations

Alzheimer paired helical filaments Restoration of the biological activity by dephosphorylation

1994 • 151 citations

Differential effect of phosphorylation and substrate modulation on tau's ability to promote microtubule growth and nucleation.

1994 • 85 citations

Rapid Alzheimer‐like phosphorylation of tau by the synergistic actions of non‐proline‐dependent protein kinases and GSK‐3

1995 • 81 citations

Calcium/calmodulin‐dependent protein kinase II phosphorylates tau at Ser‐262 but only partially inhibits its binding to microtubules

1996 • 78 citations

Ethanol enhances synaptically evoked GABAA receptor-mediated responses in cerebral cortical neurons in rat brain slices

1992 • 78 citations

Phosphorylation by Neuronal cdc2-like Protein Kinase Promotes Dimerization of Tau Protein in Vitro

1997 • 76 citations

The Regulatory Ser262 of Microtubule-associated Protein Tau Is Phosphorylated by Phosphorylase Kinase

1997 • 64 citations

Differential Phosphorylation of τ by Cyclic AMP‐Dependent Protein Kinase and Ca²⁺/Calmodulin‐Dependent Protein Kinase II: Metabolic and Functional Consequences

1992 • 57 citations

Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases

1994 • 53 citations

Differential Phosphorylation of Human Tau Isoforms Containing Three Repeats by Several Protein Kinases

1996 • 32 citations

Protein kinase C and calcium/calmodulin-dependent protein kinase II phosphorylate three-repeat and four-repeat tau isoforms at different rates.

1997 • 28 citations

The State of Phosphorylation of Normal Adult Brain τ, Fetal τ, and τ from Alzheimer Paired Helical Filaments at Amino Acid Residue Ser²⁶²

1996 • 16 citations

Activation of Ca2+/calmodulin-dependent protein kinase II by stimulation with bradykinin in neuroblastoma x glioma hybrid NG108-15 cells

1992 • 15 citations

Phosphorylation of microtubule-associated protein tau on Ser 262 by an embryonic 100 kDa protein kinase

1997 • 15 citations