Peptide selection by MHC-encoded TAP transporters

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

Empty MHC class I molecules come out in the cold

1990 • 933 citations

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 • 726 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

1990 • 644 citations

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

1993 • 572 citations

Selective and ATP-Dependent Translocation of Peptides by the MHC-Encoded Transporter

1993 • 556 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

1993 • 453 citations

Cellular peptide composition governed by major histocompatibility complex class I molecules

1990 • 438 citations

Transport Protein Genes in the Murine MHC: Possible Implications for Antigen Processing

1990 • 438 citations

A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC

1991 • 427 citations

MHC class II region encoding proteins related to the muKidrug resistance family of transmembrane transporters

1990 • 426 citations

Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro

1990 • 418 citations

Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter

1991 • 413 citations

Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

1992 • 407 citations

Presentation of viral antigen controlled by a gene in the major histocompatibility complex

1990 • 381 citations

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

1993 • 365 citations

Second proteasome-related gene in the human MHC class II region

1991 • 348 citations

Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule

1992 • 344 citations

Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen.

1988 • 331 citations

Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter

1991 • 329 citations

Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer

1992 • 322 citations

A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation

1993 • 317 citations

Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.

1994 • 314 citations

Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes

1991 • 310 citations

Ham-2 corrects the class I antigen-processing defect in RMA-S cells

1992 • 289 citations

Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex

1991 • 262 citations

Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene

1991 • 256 citations

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

1992 • 250 citations

Allelic variants of the human putative peptide transporter involved in antigen processing.

1992 • 235 citations

Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules

1992 • 215 citations

Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis.

1991 • 215 citations

Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi

1992 • 208 citations

Defective Presentation of Endogenous Antigen by a Cell Line Expressing Class I Molecules

1990 • 202 citations

Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.

1992 • 190 citations

RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes.

1992 • 132 citations

Measles virus transmembrane fusion protein synthesized de novo or presented in immunostimulating complexes is endogenously processed for HLA class I- and class II-restricted cytotoxic T cell recognition.

1992 • 131 citations

Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells.

1993 • 95 citations

Surface appearance and instability of empty H-2 class I molecules under physiological conditions.

1991 • 93 citations

ATP is required for in vitro assembly of MHC class I antigens but not to transfer of peptides acrosss the ER membrane

1991 • 92 citations

Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin‐dependent diabetes mellitus

1993 • 90 citations

Transporter-independent processing of HIV-1 envelope protein for recognition by CD8+ T cells

1993 • 90 citations

Protection from insulin‐dependent diabetes mellitus is linked to a peptide transporter gene

1993 • 76 citations

Folding and assembly of major histocompatibility complex class I heterodimers in the endoplasmic reticulum of intact cells precedes the binding of peptide.

1993 • 73 citations

An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S.

1992 • 72 citations

Uneven tissue distribution of minor histocompatibility proteins versus peptides is caused by MHC expression

1991 • 68 citations

TAP2‐defective RMA‐S cells present Sendai virus antigen to cytotoxic T lymphocytes

1993 • 44 citations

Antigen processing mutant T2 cells present viral antigen restricted through H‐2K

1993 • 44 citations

Evidence for peptide transport across microsomal membranes.

1992 • 31 citations

The assembly of H2‐K^b class I molecules translated in vitro requires oxidized glutathione and peptide

1993 • 26 citations

Cytotoxic T lymphocytes against the antigen‐processing‐defective RMA‐S tumor cell line

1992 • 24 citations

Gene transfer experiments imply instructive role of major histocompatibility complex class I molecules in cellular peptide processing

1992 • 20 citations