Effect of Antigen-Processing Efficiency on In Vivo T Cell Response Magnitudes

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

1996 • 452 citations

The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread

1995 • 435 citations

Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes

1991 • 425 citations

Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability.

1996 • 389 citations

Quantification of antigen specific CD8+ T cells using an ELISPOT assay

1995 • 367 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

1991 • 303 citations

Antigen processing in vivo and the elicitation of primary CTL responses.

1995 • 226 citations

MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL.

1997 • 207 citations

Listeria monocytogenes mutants lacking phosphatidylinositol-specific phospholipase C are avirulent.

1991 • 194 citations

Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.

1996 • 189 citations

Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes.

1992 • 184 citations

Trimming of antigenic peptides in an early secretory compartment.

1994 • 169 citations

Direct sequence identification and kinetic analysis of an MHC class I-restricted Listeria monocytogenes CTL epitope.

1994 • 161 citations

Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses.

1995 • 148 citations

Immunodominant and subdominant CTL responses to Listeria monocytogenes infection.

1997 • 146 citations

The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4.

1996 • 132 citations

Efficiency of MHC class I antigen processing: A quantitative analysis

1994 • 121 citations

MHC class I antigen processing of Listeria monocytogenes proteins: implications for dominant and subdominant CTL responses

1997 • 112 citations

B7-CD28 costimulation unveils the hierarchy of tumor epitopes recognized by major histocompatibility complex class I-restricted CD8+ cytolytic T lymphocytes.

1996 • 100 citations

Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies.

1996 • 99 citations

Point mutation flanking a CTL epitope ablates in vitro and in vivo recognition of a full-length viral protein.

1997 • 93 citations

Enhanced Intracellular Dissociation of Major Histocompatibility Complex Class I–associated Peptides: A Mechanism for Optimizing the Spectrum of Cell Surface–Presented Cytotoxic T Lymphocyte Epitopes

1997 • 89 citations

Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen

1995 • 87 citations

Influence of antigen dose and costimulation on the primary response of CD8+ T cells in vitro.

1996 • 87 citations

Immunodominance of major histocompatibility complex class I-restricted influenza virus epitopes can be influenced by the T-cell receptor repertoire

1995 • 81 citations

Identification of a major I-Ek-restricted determinant of hen egg lysozyme: limitations of lymph node proliferation studies in defining immunodominance and crypticity.

1995 • 69 citations

CTL epitope generation is tightly linked to cellular proteolysis of a Listeria monocytogenes antigen.

1996 • 58 citations

Unresponsiveness to a self-peptide of mouse lysozyme owing to hindrance of T cell receptor-major histocompatibility complex/peptide interaction caused by flanking epitopic residues.

1996 • 57 citations

Quantitative analysis of T cell activation: role of TCR/ligand density and TCR affinity.

1996 • 49 citations

Hindrance of binding to class II major histocompatibility complex molecules by a single amino acid residue contiguous to a determinant leads to crypticity of the determinant as well as lack of response to the protein antigen.

1995 • 48 citations

The weak CD8+ CTL response to an influenza hemagglutinin epitope reflects limited T cell availability.

1996 • 40 citations

Infection with Listeria monocytogenes impairs sialic acid addition to host cell glycoproteins.

1994 • 24 citations

Interference with the binding of a naturally processed peptide to class II alters the immunodominance of T cell epitopes in vivo.

1994 • 23 citations