Genetic Regulation of Autoimmune Disease: BALB/c Background TGF-β1-Deficient Mice Develop Necroinflammatory IFN-γ-Dependent Hepatitis

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

A T cell-dependent experimental liver injury in mice inducible by concanavalin A.

1992 • 1,041 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis

2000 • 747 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

Advanced intercross lines, an experimental population for fine genetic mapping.

1995 • 586 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6.

1994 • 519 citations

Essential roles of the Fas ligand in the development of hepatitis

1997 • 483 citations

Concanavalin A?induced T-cell?Mediated hepatic injury in mice: The role of tumor necrosis factor*1

1995 • 481 citations

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4⁺ T cells

1995 • 423 citations

Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A

1996 • 421 citations

Host genetic factors influence disease progression in chronic hepatitis C

2000 • 412 citations

Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines

1996 • 408 citations

Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.

1997 • 398 citations

Susceptibility to autoimmune chronic active hepatitis: Human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors

1991 • 379 citations

Cytokine regulation of liver injury and repair

2000 • 296 citations

Susceptibility to Leishmania major Infection in Interleukin-4-Deficient Mice

1996 • 292 citations

T helper type 1 development of naive CD4⁺ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β

1994 • 288 citations

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

1994 • 282 citations

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

1995 • 275 citations

Selective Retention of Activated CD8+ T Cells by the Normal Liver

1999 • 256 citations

Perforin, Fas/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL.

1997 • 256 citations

Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.

1991 • 254 citations

Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms and susceptibility to type 1 autoimmune hepatitis

2000 • 240 citations

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression.

1996 • 236 citations

Immune dysregulation in TGF-beta 1-deficient mice.

1994 • 231 citations

Chronic active hepatitis in transgenic mice expressing interferon-gamma in the liver.

1994 • 217 citations

Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses.

1996 • 204 citations

Frequency and nature of cytokine gene polymorphisms in type 1 autoimmune hepatitis

1999 • 178 citations

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis

1997 • 176 citations

Transforming growth factor-beta 1 null mice. An animal model for inflammatory disorders.

1995 • 168 citations

Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice

1997 • 166 citations

Involvement of tumor necrosis factor-α in development of hepatic injury in galactosamine-sensitized mice

1990 • 159 citations

Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.

1998 • 159 citations

Disparate Roles for TNF-α and Fas Ligand in Concanavalin A-Induced Hepatitis

1998 • 150 citations

Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology

1994 • 142 citations

Protective effect of hepatocyte growth factor on interferon-gamma—induced cytotoxicity in mouse hepatocytes

1995 • 135 citations

Hepatitis B Virus Transgenic Mice: Models of Viral Immunobiology and Pathogenesis

1996 • 134 citations

Concanavalin A—induced T-cell—mediated hepatic injury in mice: The role of tumor necrosis factor

1995 • 118 citations

Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells.

1998 • 117 citations

Low Dose TGF-β Attenuates IL-12 Responsiveness in Murine Th Cells

1998 • 96 citations

Onset and progression of pathological lesions in transforming growth factor-beta 1-deficient mice.

1995 • 95 citations

Pathogenesis of autoimmune hepatitis

1999 • 88 citations

Immunological tolerance – the liver effect

2000 • 85 citations

Strain dependency of TGF?1 function during embryogenesis

1999 • 84 citations

Differential activation of CD8+ T cells by transforming growth factor-beta 1.

1993 • 77 citations

T Cell Stimulus-Induced Crosstalk between Lymphocytes and Liver Macrophages Results in Augmented Cytokine Release

1996 • 74 citations

Role of transforming growth factor‐βthe preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B

1993 • 71 citations

TGF-β influences the life and death decisions of T lymphocytes

2000 • 70 citations

Murine models define the role of TGF-β as a master regulator of immune cell function

2000 • 68 citations

Indispensable Role for TNF-α and IFN-γ at the Effector Phase of Liver Injury Mediated by Th1 Cells Specific to Hepatitis B Virus Surface Antigen

2000 • 66 citations

Opposing effects of TGF-beta 2 on the Th1 cell development of naive CD4+ T cells isolated from different mouse strains.

1995 • 60 citations

Cellular expression of tumour necrosis factor-α and interferon-γ in the liver biopsies of children with chronic liver disease

1994 • 49 citations

Analysis of the in vitro cytokine production by liver-infiltrating T cells of patients with autoimmune hepatitis

1993 • 45 citations

Germ-free and barrier-raised TGF beta 1-deficient mice have similar inflammatory lesions.

1997 • 38 citations

The Liver in Transforming Growth Factor-Beta-1 (TGF-β1) Null Mutant Mice

1996 • 30 citations

Tumor necrosis factor production by rat Kupffer cells-regulation by lipopolysaccharide, macrophage activating factor and prostaglandin E2.

1996 • 12 citations