Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin.

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.

1977 • 1,311 citations

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.

1977 • 1,239 citations

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution.

1986 • 517 citations

Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli

1987 • 449 citations

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

1989 • 420 citations

Human squamous cell lung cancers express increased epidermal growth factor receptors.

1984 • 371 citations

A method for increasing the yield of properly folded recombinant fusion proteins: Single-chain immunotoxins from renaturation of bacterial inclusion bodies

1992 • 343 citations

Recombinant Toxins for Cancer Treatment

1991 • 308 citations

Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.

1990 • 267 citations

Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.

1988 • 265 citations

LABORATORY SYNTHESIS OF POLYETHYLENE GLYCOL DERIVATIVES

1985 • 256 citations

Cancer therapy with chemically modified enzymes. I. Antitumor properties of polyethylene glycol-asparaginase conjugates.

1984 • 256 citations

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

1988 • 253 citations

Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model.

1987 • 248 citations

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

1991 • 219 citations

Functional Analysis of Domains II, Ib, and III of Pseudomonas exotoxin

1989 • 193 citations

Surface modification of proteins activation of monomethoxy-polyethylene glycols by phenylchloroformates and modification of ribonuclease and superoxide dismutase

1985 • 183 citations

A method for the estimation of polyethylene glycol in plasma protein fractions

1980 • 156 citations

A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins.

1990 • 156 citations

Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol.

1991 • 104 citations

Nucleotide Sequence of a Human Immunoglobulin Cγ4 Gene

1981 • 91 citations

Receptors for epidermal growth factor and steroid hormones in primary laryngeal tumors

1991 • 88 citations

Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv).

1991 • 81 citations

Chemical engineering of the monoclonal antibody A7 by polyethylene glycol for targeting cancer chemotherapy.

1991 • 80 citations

The determination of polyethylene glycol in gamma globulin solutions

1975 • 68 citations

Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40).

1991 • 66 citations

The solution structure of human transforming growth factor α

1991 • 65 citations

Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice.

1990 • 64 citations

Structure-function analysis of synthetic and recombinant derivatives of transforming growth factor alpha.

1988 • 57 citations

Enzyme-Polyethylene Glycol Adducts: Modified Enzymes with Unique Properties

1978 • 56 citations

Suppression of IgE Antibody Responses with Tolerogenic Conjugates of Allergens and Haptens

2015 • 54 citations

Preparation of polyethylene glycol-tissue plasminogen activator adducts that retain functional activity: characteristics and behavior in three animal species

1988 • 52 citations

Epidermal growth factor receptors on ependymomas and other brain tumors

1990 • 47 citations

Polyethylene glycol modification of the monoclonal antibody A7 enhances its tumor localization

1990 • 42 citations

Antitumor effects of interleukin 6-Pseudomonas exotoxin chimeric molecules against the human hepatocellular carcinoma, PLC/PRF/5 in mice.

1991 • 36 citations

Rational design of a chimeric toxin: an intramolecular location for the insertion of transforming growth factor .alpha. within Pseudomonas exotoxin as a targeting ligand

1992 • 22 citations

Immunotoxins and cytokine toxin fusion proteins.

1990 • 14 citations