The potential role of NK cells in the separation of graft‐versus‐tumor effects from graft‐versus‐host disease after allogeneic bone marrow transplantation

Biology of Natural Killer Cells

1989 • 2,970 citations

Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

1995 • 1,828 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease

1995 • 535 citations

The Ly-49 and NKR-P1 Gene Families Encoding Lectin-Like Receptors on Natural Killer Cells: The NK Gene Complex

1993 • 465 citations

In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.

1981 • 424 citations

PECULIAR IMMUNOBIOLOGY OF BONE MARROW ALLOGRAFTS

1971 • 349 citations

Adoptive transfer studies demonstrating the antiviral effect of natural killer cells in vivo.

1985 • 327 citations

Capacity of human large granular lymphocytes (LGL) to produce multiple lymphokines: interleukin 2, interferon, and colony stimulating factor.

1983 • 294 citations

Do Natural Killer Cells Engage in Regulated Reactions Against Self to Ensure Homeostasis?

1979 • 287 citations

Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor

1995 • 269 citations

Rejection of bone marrow allografts by mice with severe combined immune deficiency (SCID). Evidence that natural killer cells can mediate the specificity of marrow graft rejection.

1987 • 242 citations

The Role of Ly49A and 5E6(Ly49C) Molecules in Hybrid Resistance Mediated by Murine Natural Killer Cells Against Normal T Cell Blasts

1996 • 234 citations

The role of interleukin 12 in the immune response, disease and therapy

1994 • 221 citations

Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production

1995 • 221 citations

Murine Natural Killer Cells and Marrow Graft Rejection

1992 • 217 citations

Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease.

1995 • 204 citations

Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans.

1993 • 195 citations

Biology and Genetics of Hybrid Resistance

1987 • 191 citations

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.

1994 • 187 citations

The developmental relationship between NK cells and T cells

1992 • 183 citations

Allorecognition by NK cells: nonself or no self?

1992 • 182 citations

Consolidation treatment of adult acute lymphoblastic leukemia: a prospective, randomized trial comparing allogeneic versus autologous bone marrow transplantation and testing the impact of recombinant interleukin-2 after autologous bone marrow transplantation. BGMT Group

1995 • 162 citations

Anti-leukemia potential of interleukin-2 activated natural killer cells after bone marrow transplantation for chronic myelogenous leukemia

1990 • 150 citations

IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells.

1996 • 148 citations

Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment.

1994 • 147 citations

Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts

1995 • 144 citations

Interleukin-12 inhibits murine graft-versus-host disease

1995 • 128 citations

Role of neuroendocrine hormones in murine T cell development. Growth hormone exerts thymopoietic effects in vivo.

1992 • 126 citations

Immunologic and hematologic effects of neuroendocrine hormones. Studies on DW/J dwarf mice.

1992 • 125 citations

Interleukin 2 prevents graft-versus-host disease while preserving the graft-versus-leukemia effect of allogeneic T cells.

1990 • 122 citations

Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells.

1996 • 120 citations

Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts

1995 • 119 citations

Toxicity and immunomodulatory effects of interleukin-2 after autologous bone marrow transplantation for hematologic malignancies

1991 • 118 citations

Mouse natural killer cells express gp49B1, a structural homologue of human killer inhibitory receptors.

1997 • 116 citations

NATURAL KILLER CELL ACTIVITY IN HUMAN BONE MARROW RECIPIENTS EARLY REAPPEARANCE OF PERIPHERAL NATURAL KILLER ACTIVITY IN GRAFT-VERSUS-HOST DISEASE

1981 • 114 citations

Hematologic and immunologic effects of the systemic administration of recombinant interleukin-2 after autologous bone marrow transplantation

1990 • 112 citations

Recombinant human granulocyte-macrophage colony-stimulating factor accelerates neutrophil and monocyte recovery after allogeneic T-cell- depleted bone marrow transplantation

1992 • 93 citations

Effects of growth hormone and prolactin immune development and function

1995 • 90 citations

Lysis of neuroblastoma cell lines by human natural killer cells activated by interleukin-2 and interleukin-12

1994 • 79 citations

Autologous peripheral blood stem cell transplantation and adoptive immunotherapy with activated natural killer cells in the immediate posttransplant period.

1995 • 78 citations

Hematopoietic stem cells are not direct cytotoxic targets of natural killer cells

1996 • 77 citations

Recombinant human granulocyte-macrophage colony-stimulating factor accelerates neutrophil and monocyte recovery after allogeneic T-cell- depleted bone marrow transplantation

1992 • 73 citations

Interleukin-2-activated natural killer cells can support hematopoiesis in vitro and promote marrow engraftment in vivo

1992 • 67 citations

Donor-type activated natural killer cells promote marrow engraftment and B cell development during allogeneic bone marrow transplantation.

1992 • 64 citations

Graft‐versus‐leukaemia activity can be predicted by natural cytotoxicity against leukaemia cells

1996 • 61 citations

An absence of T cells in murine bone marrow allografts leads to an increased susceptibility to rejection by natural killer cells and T cells.

1990 • 60 citations

Natural Killer Cells and Bone Marrow Transplantation

1993 • 57 citations

Interleukin-2-activated natural killer cells can support hematopoiesis in vitro and promote marrow engraftment in vivo

1992 • 56 citations

Growth hormone exerts hematopoietic growth-promoting effects in vivo and partially counteracts the myelosuppressive effects of azidothymidine

1992 • 56 citations

ALLOGENEIC NK CELLS AS POTENT ANTILEUKEMIC EFFECTOR CELLS AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION IN MICE

1995 • 56 citations

Prevention of lethal, minor-determinate graft-host disease in mice by the in vivo administration of anti-asialo GM1.

1983 • 54 citations

Growth hormone exerts hematopoietic growth-promoting effects in vivo and partially counteracts the myelosuppressive effects of azidothymidine

1992 • 49 citations

Anti-asialo GM1 antiserum treatment of lethally irradiated recipients before bone marrow transplantation: evidence that recipient natural killer depletion enhances survival, engraftment, and hematopoietic recovery

1990 • 49 citations

Phase I trial of interleukin-2 after unmodified HLA-matched sibling bone marrow transplantation for children with acute leukemia

1996 • 47 citations

Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantation. The IgE allotype is an important marker of graft-versus-host disease.

1995 • 47 citations

Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules.

1995 • 46 citations

Systemic interleukin-2 therapy in children with progressive neuroblastoma after high dose chemotherapy and bone marrow transplantation.

1989 • 44 citations

Molecular remission occurring after donor leukocyte infusions for the treatment of relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation.

1992 • 43 citations

Role of lymphokine-activated killer cells as mediators of veto and natural suppression.

1988 • 43 citations

Ly-49 G2⁺ NK cells are responsible for mediating the rejection of H-2^b bone marrow allog rafts in mice

1996 • 36 citations

Production of granulocyte/macrophage-colony-stimulating factor by human natural killer cells. Modulation by the p75 subunit of the interleukin 2 receptor and by the CD2 receptor.

1991 • 35 citations

TGF-beta mediates natural suppressor activity of IL-2-activated lymphocytes.

1994 • 34 citations

Mechanism of protection from graft-versus-host disease mortality by IL-2. III. Early reductions in donor T cell subsets and expansion of a CD3+CD4-CD8- cell population.

1992 • 32 citations

KINETICS OF NATURAL KILLER CELLCYTOTOXICITY REACTION

1987 • 32 citations

Granulocyte-colony-stimulating factor after allogeneic and autologous bone marrow transplantation in children

1996 • 28 citations

PREVENTION OF MURINE GRAFT-VERSUS-HOST DISEASE BY INDUCING AND ELIMINATING ASGM1+ CELLS OF DONOR ORIGIN

1988 • 27 citations

Evidence for a possible role of Asialo-GM1-positive cells in the graft-versus-leukemia repression of a murine type-C retroviral leukemia.

1995 • 22 citations

Activated natural killer cells and interleukin-2 promote granulocytic and megakaryocytic reconstitution after syngeneic bone marrow transplantation in mice

1993 • 22 citations

GRAFT VERSUS LEUKEMIA EFFECT AFTER TRANSPLANTATION WITH INTERLEUKIN-2-ACTIVATED BONE MARROW

1993 • 19 citations

Transfusion of donor buffy coat cells in the treatment of persistent or recurrent malignancy after allogeneic bone marrow transplantation

1995 • 19 citations

The role of antibodies to IL-2 receptor and Asialo GM1 on graft-versus-leukemia effects induced by bone marrow allografts in murine B cell leukemia.

1995 • 18 citations

Transfer of specific immunity to B-cell lymphoma with syngeneic bone marrow in mice: a strategy for using autologous marrow as an anti-tumor therapy

1991 • 18 citations

Low doses of rIL2 after autologous bone marrow transplantation induce a “prolonged” immunostimulation of NK compartment in high-grade non-Hodgkin's lymphomas

1995 • 17 citations

NK Cells in the Regulation of Hematopoiesis

1996 • 15 citations

A SYNERGISTIC INCREASE IN TRANSPLANTABLE PERIPHERAL BLOOD STEM CELLS IN MICE BY CO-ADMINISTRATION OF RECOMBINANT HUMAN INTERLEUKIN 6 AND RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR

1995 • 13 citations

IL-2-induced GVHD protection is not inhibited by cyclosporine and is maximal when IL-2 is given over a 25 h period beginning on the day following bone marrow transplantation.

1995 • 13 citations

Spontaneous alloreactivity of natural killer (NK) and lymphokine-activated killer (LAK) cells from athymic rats against normal haemic cells. NK cells stimulate syngeneic but inhibit allogeneic haemopoiesis.

1991 • 12 citations

Donor buffy coat infusions for a patient with myelodysplastic syndrome who relapsed following allogeneic bone marrow transplantation.

1995 • 12 citations

Adoptive Immunotherapy for Relapsed Leukemia Following Allogeneic Bone Marrow Transplantation

1995 • 11 citations

The Role of Natural Killer Cells in the Treatment of Chronic Myeloid Leukemia

1995 • 10 citations

Transplantation of t‐lymphocyte depleted marrow with an addback of T cells

1995 • 6 citations

Hematopoietic Growth promoting Effects of Natural Killer Cells in Mice in responce to In Vivo Administration of Human Interleukin-2

1992 • 5 citations

Recent Advances in Bone Marrow Transplantation from Unrelated Volunteer Donors

1996 • 3 citations