Trans-racial studies implicate HLA-DQ as a component of genetic susceptibility to Type 1 (insulin-dependent) diabetes

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

HLA-D region β-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals

1983 • 265 citations

A DNA-RFLP TYPING SYSTEM THAT POSITIVELY IDENTIFIES SEROLOGICALLY WELL-DEFINED AND ILL-DEFINED HLA-DR AND DQ ALLELES, INCLUDING DRw10

1988 • 229 citations

Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis.

1986 • 193 citations

Six HLA-D region alpha-chain genes on human chromosome 6: polymorphisms and associations of DC alpha-related sequences with DR types.

1984 • 163 citations

A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.

1985 • 134 citations

Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene.

1985 • 133 citations

HLA-DR-DQ haplotypes defined by restriction fragment analysis

1987 • 128 citations

A review of theoretical aspects of HLA and disease associations

1981 • 121 citations

Insulin-Dependent Diabetes Mellitus

1984 • 117 citations

The Data and Statistical Analysis

1985 • 102 citations

Only one DQ-beta restriction fragment pattern of each DR specificity is associated with insulin-dependent diabetes.

1986 • 100 citations

HLA-DO polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism.

1986 • 87 citations

HLA associations in insulin‐dependent diabetes: search for heterogeneity in different groups of patients from a homogeneous population

1986 • 74 citations

Polymorphism of the HLA-D region in American blacks. A DR3 haplotype generated by recombination.

1988 • 70 citations

HLA-DR Specificities among Black Americans with Juvenile-Onset Diabetes

1979 • 54 citations

Association of HLA-DQw3 (TA10−) With Type I Diabetes Occurs With DR3/4 but not DR1/4 Patients

1988 • 43 citations

Class II HLA DNA polymorphisms in Type 1 (insulin-dependent) diabetic patients of North Indian origin

1988 • 36 citations

HLA Associations with Insulin‐Dependent Diabetes Mellitus in a Sample of the American Black Population*

1981 • 34 citations

HLA-DRw Antigens in Mexican-American and Black-American Diabetic Patients

1980 • 32 citations

HLA-A, B, C and DR antigens in young South African blacks with Type 1 (insulin-dependent) diabetes mellitus

1984 • 30 citations

HLA-DR Associations in Black Type I Diabetics in Nigeria: Further Support for Models of Inheritance

1986 • 30 citations

Association of HLA-DQw3 (TA10-) with type I diabetes occurs with DR3/4 but not DR1/4 patients

1988 • 27 citations

DR4 and susceptibility to type I diabetes mellitus: discrimination of high risk and low risk DR4 haplotypes on the basis of TA10 typing

1986 • 25 citations

HLA‐A, B, C and DR antigen associations in insulin dependent diabetes mellitus (IDDM) in South African Negro (Black) and Cape Coloured people

1985 • 24 citations

Insulin-Dependent Diabetes Mellitus

1980 • 23 citations

Polymorphisms of DQ ? genes in HLA-DR4 haplotypes from healthy and diabetic individuals

1987 • 22 citations

HLA‐DR and DQ antigens in insulin‐dependent diabetics in Ethiopia

1987 • 22 citations

HLA-DRw antigens in Mexican-American and Black-American diabetic patients

1980 • 20 citations

Genomic HLA‐DQβ Polymorphism Associated with Insulin‐Dependent Diabetes Mellitus

1987 • 18 citations

HLA-DR associations in black type I diabetics in Nigeria. Further support for models of inheritance

1986 • 16 citations

Segregation of DQ and DR: “Exceptions to the Rule”

1984 • 16 citations