Inhibition of human glutathione reductase by the nitrosourea drugs 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea and 1‐(2‐chloroethyl)‐3‐(2‐hydroxyethyl)‐1‐nitrosourea

An efficient general-purpose least-squares refinement program for macromolecular structures

1987 • 871 citations

Refined structure of glutathione reductase at 1.54 Å resolution

1987 • 498 citations

The catalytic mechanism of glutathione reductase as derived from x-ray diffraction analyses of reaction intermediates.

1983 • 323 citations

The structure of the flavoenzyme glutathione reductase

1978 • 279 citations

Three-dimensional structure of glutathione reductase at 2 Å resolution

1981 • 257 citations

Glutathione Reductase from Human Erythrocytes

1982 • 238 citations

Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis

1981 • 220 citations

3 Flavin-Containing Dehydrogenases

1976 • 205 citations

Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme

1987 • 195 citations

Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates

1978 • 188 citations

Severe generalized glutathione reductase deficiency after antitumor chemotherapy with BCNU" [1,3-bis(chloroethyl)-1-nitrosourea].

1977 • 176 citations

Glutathione Reductase from Human Erythrocytes

1977 • 175 citations

Coenzymes and Cofactors

2015 • 106 citations

Glutathione reductase from yeast. Differential reactivity of the nascent thiols in two-electron reduced enzyme and properties of a monoalkylated derivative

1981 • 95 citations

Oxidative Stress as a Defense Mechanism Against Parasitic Infections

1987 • 91 citations

Interaction of a glutathione S‐conjugate with glutathione reductase Kinetic and X‐ray crystallographic studies

1984 • 86 citations

Glutathione Reductase from Human Erythrocytes. Amino-Acid Sequence of the Structurally Known FAD-Binding Domain

1981 • 84 citations

DNA adducts and DNA damage by antineoplastic and carcinogenic N-nitrosocompounds

1986 • 37 citations

Crystals of human erythrocyte glutathione reductase

1975 • 30 citations

Active site-specific inhibition by 1,3-bis(2-chloroethyl)-1-nitrosourea of two genetically homologous flavoenzymes: glutathione reductase and lipoamide dehydrogenase.

1985 • 21 citations

The crystal structure of phenylthiazolidinedione

1964 • 8 citations