DNA adducts and DNA damage by antineoplastic and carcinogenic N-nitrosocompounds

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

DNA repair: a laboratory manual of research procedures

1981 • 818 citations

All oxygens in nucleic acids react with carcinogenic ethylating agents

1976 • 311 citations

Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

1982 • 227 citations

The Modes of Decomposition of 1,3-Bis(2-chloroethyl)-1-nitrosourea and Related Compounds

1967 • 177 citations

Nitrosoureas : current status and new developments

1981 • 163 citations

Synthesis of chlorozotocin, the 2-chloroethyl analog of the anticancer antibiotic streptozotocin

1975 • 85 citations

Automated determination of DNA using the fluorochrome Hoechst 33258

1985 • 75 citations

Modifications of DNA by different haloethylnitrosoureas.

1982 • 69 citations

Nitrosourea-induced DNA single-strand breaks

1979 • 58 citations

The influence of N7 substituents on the stability of N7-alkylated guanosines

1985 • 54 citations

Mechanism of action of the nitrosoureas—IV

1980 • 51 citations

Mechanism of action of the nitrosoureas—1

1978 • 43 citations

Interaction of chemical carcinogens with macromolecules

1981 • 43 citations

Synthesis of specifically nitrogen-15- and carbon-13-labeled antitumor (2-haloethyl)nitrosoureas. The study of their conformations in solution by nitrogen-15 and carbon-13 nuclear magnetic resonance electronic control in their aqueous decomposition

1981 • 41 citations

Identification of the methyl phosphotriester of thymidylyl (3′-5′)thymidine as a product from reaction of DNA with the carcinogen N-methyl-N-nitrosourea

1976 • 35 citations

Chemistry of nitrosoureas. Intermediacy of 4,5-dihydro-1,2,3-oxadiazole in 1,3-bis(2-chloroethyl)-1-nitrosourea decomposition

1980 • 35 citations

Studies on the stability of trialkyl phosphates and di-(2′-deoxythymidine) phosphotriesters in alkaline and neutral solution. A model study for hydrolysis of phosphotriesters in DNA and on the influence of a β hydroxyethyl ester group

1986 • 33 citations

Alcoholdehydrogenase as an activating enzyme for N-nitrosodiethanolamine (NDELA): In vitro activation of NDELA to a potent mutagen in Salmonella typhimurium

1984 • 33 citations

Carcinogenicity of hydroxylated alkylnitrosoureas and of nitrosooxazolidones by mouse skin painting and by gavage in rats.

1983 • 33 citations

Mechanism of action of (2-haloethyl)nitrosoureas on DNA. Isolation and reactions of postulated 2-(alkylimino)-3-nitrosooxazolidine intermediates in the decomposition of 1,3-bis(2-chloroethyl)-, 1-(2-chloroethyl)-3-cyclohexyl-, and 1-(2-chloroethyl)-3-(4'-trans-methylcyclohexyl)-1-nitrosourea

1981 • 33 citations

Biological activity of N-nitrosodiethanolamine and of potential metabolites which may arise after activation by alcohol dehydrogenase in Salmonella typhimurium, in mammalian cells, and in vivo

1986 • 32 citations

Estrogen-linked 2-chloroethylnitrosoureas: Anticancer efficacy in MNU-induced rat mammary carcinoma, uterine activity in mice and receptor interactions

1986 • 30 citations

N-Nitrosodiethanolamine is activated in the rat to an ultimate genotoxic metabolite by sulfotransferase

1986 • 28 citations

Mechanism of action of the nitrosoureas—III

1979 • 26 citations

Mechanism of Hydrolysis of Halogenated Nitrosoureas

1978 • 23 citations

Identification of an acidic metabolite ofN-nitrosodiethanolamine isolated from rat urine

1983 • 21 citations

Anticancer Activity of New Nitrosoureas against Walker Carcinosarcoma 256 and DMBA-Induced Mammary Cancer of the Rat

1980 • 21 citations

Decomposition reactions of (hydroxyalkyl)nitrosoureas and related compounds: possible relationship to carcinogenicity

1985 • 18 citations

MODIFICATION OF DNA AND RNA BASES

1981 • 18 citations

Similar carcinogenic effects in rats of 1-ethyl-1-nitroso-3-hydroxyethylurea and 1-hydroxyethyl-1-nitroso-3-ethylurea

1985 • 18 citations

Mechanism of action of the nitrosoureas: Formation of 1,2-(diguanosin-7-yl) ethane from the reaction of BCNU (1,3-bis-[2-chloroethyl]-1-nitrosourea) with guanosine

1979 • 18 citations

DNA damage and repair in the bone marrow of rats treated with four chloroethylnitrosoureas.

1984 • 17 citations

Examination of four newly synthesized 2-chloroethylnitrosoureas in comparison with BCNU, CCNU, MeCCNU, chlorozotocin and hydroxyethyl-CNU in preterminal rat leukemia L 5222

1979 • 16 citations

The level of DNA interstrand crosslinking in bone marrow parallels the extent of myelosuppression in mice treated with four chloroethylnitrosoureas

1984 • 16 citations

Synthesis and reactions of deuterated 2-(alkylimino)-3-nitrosooxazolidines, 3-alkyl-1-(2-hydroxyethyl)-1-nitrosoureas, and related compounds as possible intermediates in the aqueous decomposition of 3-alkyl-1-(2-chloroethyl)-1-nitrosoureas

1981 • 15 citations

N-Nitroso-2-hydroxymorpholine, a mutagenic metabolite of N-nitrosodiethanolamine

1984 • 15 citations

Drug design: nitrosoureas.

1986 • 9 citations

Relationship between DNA damage and the inhibition of stem cells in murine bone marrow after single and repeated administration of BCNU and HECNU

1985 • 4 citations

Oxidative Activation of N-Nitrosamines: Model Compounds

1979 • 3 citations