The Relationship between Mhc Antigen Expression and Metastasis

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

Selection of Successive Tumour Lines for Metastasis

1973 • 1,360 citations

Natural Killer Cells: Their Roles in Defenses Against Disease

1981 • 1,353 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

1988 • 967 citations

Peptide growth factors are multifunctional

1988 • 835 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.

1985 • 734 citations

Role of MHC Gene Products in Immune Regulation

1981 • 705 citations

Natural Cell-mediated Immunity Against Tumors

1980 • 666 citations

The class II molecules of the human and murine major histocompatibility complex

1984 • 664 citations

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

1983 • 586 citations

A glycolipid on the surface of mouse natural killer cells

1980 • 539 citations

Role of NK cells in tumour growth and metastasis in beige mice

1980 • 524 citations

Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.

1987 • 508 citations

Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.

1987 • 478 citations

Why do so many lymphocytes respond to major histocompatibility antigens?

1977 • 462 citations

T cell antigen receptors and the immunoglobulin supergene family

1985 • 453 citations

THE DETAILED DISTRIBUTION OF MHC CLASS II ANTIGENS IN NORMAL HUMAN ORGANS

1984 • 435 citations

Protochordate allorecognition is controlled by a MHC-like gene system

1982 • 435 citations

NK susceptibility varies inversely with target cell class I HLA antigen expression.

1987 • 433 citations

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

1985 • 410 citations

THE DETAILED DISTRIBUTION OF HLA-A, B, C ANTIGENS IN NORMAL HUMAN ORGANS

1984 • 410 citations

Definitive evidence that natural killer (NK) cells inhibit experimental tumor metastases in vivo.

1981 • 395 citations

Role of Natural Killer Cells in the Destruction of Circulating Tumor Emboli23

1980 • 389 citations

Natural killer cells: definition of a cell type rather than a function

1987 • 385 citations

Reversal of Oncogenesis by the Expression of a Major Histocompatibility Complex Class I Gene

1985 • 375 citations

Heterogeneity of Natural Killer Cells

1984 • 368 citations

Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

1984 • 359 citations

Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer.

1985 • 358 citations

Cancer Metastasis: Experimental Approaches, Theoretical Concepts, and Impacts for Treatment Strategies

1985 • 301 citations

Direct evidence for the role of LGL in the inhibition of experimental tumor metastases.

1985 • 279 citations

Natural killer cells: definition of a cell type rather than a function.

1986 • 278 citations

Mechanism of Cytotoxicity by Natural Killer (NK) Cells

1986 • 272 citations

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

1988 • 266 citations

Striking paucity of HLA-A, B, C and beta 2-microglobulin on human neuroblastoma cell lines.

1983 • 257 citations

Immunotherapy of cancer using interleukin 2: current status and future prospects

1988 • 256 citations

c-myc down-regulates class I HLA expression in human melanomas.

1988 • 248 citations

T cells can distinguish between allogeneic major histocompatibility complex products on different cell types

1988 • 246 citations

VIRAL ONCOLYSIS: INCREASED IMMUNOGENICITY OF HOST CELL ANTIGEN ASSOCIATED WITH INFLUENZA VIRUS

1967 • 234 citations

Genetic variation of in vitro cytolytic activity and in vivo rejection potential of non‐immunized semi‐syngeneic mice against a mouse lymphoma line

1975 • 230 citations

Effects of a cloned cell line with NK activity on bone marrow transplants, tumour development and metastasis in vivo

1982 • 228 citations

Role of the Major Histocompatibility Complex Class I Antigens in Tumor Growth and Metastasis

1988 • 201 citations

The T cell receptor: the α and β chains define idiotype, and antigen and MHC specificity

1985 • 198 citations

Primary Structural Analysis of the Transplantation Antigens of the Murine H-2 Major Histocompatibility Complex

1981 • 196 citations

Immunological Surveillance of Tumors in the Context of Major Histocompatibility Complex Restriction of T Cell Function

1984 • 185 citations

Immunobiology of Natural Killer Cells

2019 • 174 citations

IMMUNOGENETICS OF CELL SURFACE ANTIGENS OF MOUSE LEUKEMIA

1977 • 174 citations

Phenotypic dynamics of tumor progression in human malignant melanoma

1985 • 172 citations

YAC-1 MHC class I variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage.

1985 • 171 citations

Immune surveillance against virus-induced tumors and nonrejectability of spontaneous tumors: contrasting consequences of host versus tumor evolution.

1977 • 169 citations

Distribution of human Class I (HLA-A,B,C) histocompatibility antigens in normal and malignant tissues of nonlymphoid origin.

1984 • 168 citations

Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice

1980 • 165 citations

Histocompatibility Antigens on Murine Tumors

1985 • 164 citations

Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse

1983 • 161 citations

The Canine Transmissible Venereal Tumor: a Unique Result of Tumor Progression

1985 • 161 citations

The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens.

1986 • 153 citations

Mechanism of rejection of virus persistently infected tumor cells by athymic nude mice.

1979 • 152 citations

Evidence that multiple residues on both the α-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor

1988 • 151 citations

Differential expression of H–2 gene products in tumour cells is associated with their metastatogenic properties

1980 • 146 citations

A nonpolymorphic class I gene in the murine major histocompatibility complex

1984 • 146 citations

Membrane glycoproteins and recognition phenomena

1977 • 141 citations

Natural killer susceptibility of human cells may be regulated by genes in the HLA region on chromosome 6.

1986 • 141 citations

Level of HLA antigens in locoregional metastases and clinical course of the disease in patients with melanoma.

1988 • 136 citations

Down-regulation of class I HLA antigens and of the Epstein-Barr virus-encoded latent membrane protein in Burkitt lymphoma lines.

1987 • 133 citations

Tumour specific immunogenicity of methylcholanthrene-induced sarcoma cells after incubation in neuraminidase.

1969 • 133 citations

HLA-A2 peptides can regulate cytolysis by human allogeneic T lymphocytes

1987 • 132 citations

MHC imbalance and metastatic spread in Lewis lung carcinoma clones

1983 • 131 citations

Heterogeneity in the expression of HLA and tumor-associated antigens by surgically removed and cultured breast carcinoma cells.

1983 • 125 citations

Effect of herpes simplex virus types 1 and 2 on surface expression of class I major histocompatibility complex antigens on infected cells

1985 • 122 citations

Variation in MHC Antigenic Profiles of Tumor Cells and its Biological Effects

1981 • 120 citations

A speculative view of the multicomponent nature of T cell antigen recognition

1986 • 117 citations

Influence of anti-mouse interferon serum on the growth and metastasis of tumor cells persistently infected with virus and of human prostatic tumors in athymic nude mice

1981 • 112 citations

The differential expression of H‐2K versus H‐2D antigens, distinguishing high‐ metastatic from low‐ metastatic clones, is correlated with the immunogenic properties of the tumor cells

1984 • 108 citations

ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS

1971 • 107 citations

Structure of Class I Major Histocompatibility Antigens

1983 • 107 citations

Clonal analysis of cytotoxic T‐lymphocyte response to autologous human metastatic melanoma

1985 • 107 citations

Interferon gamma induces lung colonization by intravenously inoculated B16 melanoma cells in parallel with enhanced expression of class I major histocompatibility complex antigens.

1987 • 107 citations

Classes I and II HLA and melanoma-associated antigen expression and modulation on melanoma cells isolated from primary and metastatic lesions.

1986 • 103 citations

Differentiation-dependent sensitivity of human B-cell-derived lines to major histocompatibility complex-restricted T-cell cytotoxicity.

1986 • 96 citations

Characterization of a progressive tumor from C3H fibroblasts transformed in vitro with SV40 virus. Immunoresistance in vivo correlates with phenotypic loss of H-2Kk.

1982 • 95 citations

Mouse Ia antigens are receptors for lactate dehydrogenase virus

1984 • 94 citations

Transfer to cyclophosphamide-treated mice of natural killer (NK) cells and in vivo natural reactivity against tumors.

1981 • 90 citations

Loss of β2 microglobulin from the cell surface of cutaneous malignant and premalignant lesions

1981 • 87 citations

Specificity of auto‐tumor cytotoxicity exerted by fresh, activated and propagated human t lymphocytes

1982 • 82 citations

Inhibition of the growth of lymphoid tumours in syngeneic athymic (nude) mice

1977 • 82 citations

Expression of major histocompatibility antigens and nature of inflammatory cellular infiltrate in ovarian neoplasms

1983 • 81 citations

Correlation of glycosphingolipids and sialic acid in YAC‐1 lymphoma variants with their sensitivity to natural killer‐cell‐mediated lysis

1981 • 81 citations

Increase of leukemia L1210 immunogenicity by Vibrio cholerae neuraminidase treatment.

1971 • 80 citations

Differential tissue distribution and ontogeny of DC-1 and HLA-DR antigens

1984 • 79 citations

Alien histocompatibility antigens on tumor cells

1979 • 77 citations

Unique Tumor-Specific Antigens

1988 • 76 citations

Tumorigenicity of adenovirus-transformed cells: Region E1A of adenovirus 12 confers resistance to natural killer cells

1985 • 74 citations

Human tumour antigens defined by cytotoxicity and proliferative responses of cultured lymphoid cells

1982 • 73 citations

Effect of Vesicular Stomatitis Virus Infection on the Histocompatibility Antigen of L Cells

1972 • 73 citations

Primordial density fluctuations and the structure of galactic haloes

1986 • 71 citations

Lung colonization and metastasis by disseminated b16 melanoma cells: H‐2 associated control at the level of the host and the tumor cell

1985 • 71 citations

In vitro NK‐activity and in vivo resistance to leukemia: Studies of beige, beige/nude and wild‐type hosts on C57BL background

1980 • 69 citations

Resistance to cell-mediated cytotoxicity is correlated with reduction of H-2K gene products in AKR leukemia

1982 • 68 citations

The inhibition of lymphocyte stimulation by autologous human metastatic melanoma cells correlates with the expression of HLA‐DR antigens on the tumor cells

1984 • 68 citations

Immunization of Mice against Ehrlich Ascites Tumour using a Hamster/Ehrlich Ascites Tumour Hybrid Cell Line

1969 • 65 citations

Synergistic defense system by cooperative natural effectors against metastasis of B16 melanoma cells in H-2-associated control: different behavior of H-2+ and H-2- cells in metastatic processes.

1986 • 62 citations

H-2 antigen expression and sensitivity of BL6 melanoma cells to natural killer cell cytotoxicity.

1988 • 60 citations

Absence of human leukocyte antigen molecules in skin tumors and some cutaneous appendages: Evidence using monoclonal antibodies

1983 • 58 citations

Heterogeneous expression of melanoma-associated antigens and HLA antigens by primary and multiple metastatic lesions removed from patients with melanoma.

1985 • 57 citations

Xenogenization of a mouse lung carcinoma (3LL) by transfection with an allogeneic class I major histocompatibility complex gene (H-2Ld).

1987 • 57 citations

The augmentation of tumor‐specific immunity by virus help. II. Enhanced induction of cytotoxic T lymphocyte and antibody responses to tumor antigens by vaccinia virus‐reactive helper T cells

1984 • 56 citations

Prevention of metastatic spread by postoperative immunotherapy with virally modified autologous tumor cells. II. Establishment of specific systemic anti-tumor immunity

1987 • 56 citations

Positive correlation between in vitro NK activity and in vivo resistance towards AKR lymphoma cells

1980 • 54 citations

Expression of a laminin-like substance on the surface of murine natural killer (NK) lymphocytes and its role in NK recognition of tumor target cells.

1985 • 51 citations

Expression of the adenovirus E1A oncogene during cell transformation is sufficient to induce susceptibility to lysis by host inflammatory cells.

1986 • 51 citations

Lysis of a lung carcinoma by poly I:C-induced natural killer cells is independent of the expression of class I histocompatibility antigens.

1988 • 50 citations

Increase in H-2 antigen expression and immunogenicity of BL6 melanoma cells treated with N-methyl-N'-nitronitrosoguanidine.

1985 • 49 citations

Enhanced metastases of a mouse carcinoma after in vitro treatment with murine interferon gamma

1987 • 48 citations

Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. III. Amplification of a generation of tumor-specific killer T-lymphocyte activities by suppressor T-cell-depleted hapten-reactive T lymphocytes.

1979 • 48 citations

Gene products of the HLA-D region in normal and malignant tissues of nonlymphoid origin

1986 • 47 citations

A single amino acid substitution in the alpha 3 domain of an H-2 class I molecule abrogates reactivity with CTL.

1987 • 47 citations

Differential Behaviour of Transplanted Mouse Lymphoma Lines in Genetically Compatible Homozygous and F1 Hybrid Mice

1963 • 47 citations

Loss of Expression of Transplantation Antigens Encoded by the <italic>H-2K</italic> Locus on Lewis Lung Carcinoma Cells and Its Relevance to the Tumor's Metastatic Properties<xref ref-type="fn" rid="FN2">2</xref>

1983 • 45 citations

Identification of a unique tumor antigen as rejection antigen by molecular cloning and gene transfer.

1986 • 44 citations

DIFFERENTIAL EXPRESSION OF HLA CLASS I AND II ANTIGENS IN PRIMARY AND METASTATIC MELANOMAS

1986 • 43 citations

Coupling PPD to tumour cells enhances their antigenicity in BCG-primed mice

1978 • 42 citations

Inhibition of chemically induced mammary carcinogenesis in rats by long-term exposure to butylated hydroxytoluene (BHT): interrelations among BHT concentration, carcinogen dose, and diet.

1986 • 42 citations

Immunohistological evaluation of MHC class I and II antigen expression on nevi and melanoma: relation to biology of melanoma

1987 • 41 citations

Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA.

1986 • 40 citations

Interferon-induced alterations in metastatic capacity, class-1 antigen expression and natural killer cell sensitivity of melanoma cells

1987 • 40 citations

Allogeneic H-2 antigen expression is insufficient for tumor rejection.

1987 • 40 citations

Is the MHC a general self-recognition system playing a major unifying role in an organism?

1980 • 38 citations

Loss of Membrane B2 Microglobulin in Eccrine Porocarcinoma

1984 • 38 citations

Differential cell adhesion may result from nonspecific interactions between cell surface glycoproteins

1978 • 38 citations

Selective acceptance of MHC class I-deficient tumor grafts in the brain.

1988 • 35 citations

Inhibition of Chemically Induced Mammary Carcinogenesis in Rats by Short-Term Exposure to Butylated Hydroxytoluene (BHT): Interrelationships Among BHT Concentration, Carcinogen Dose, and Diet234

1984 • 34 citations

Immune Responses To Metastases

1987 • 34 citations

Reduced tumorigenicity of a spontaneous mouse lung carcinoma following H-2 gene transfection.

1987 • 33 citations

LOSS OF HLA‐A,B,C IN COLORECTAL CARCINOMA IS RELATED TO THE DEGREE OF DE‐DIFFERENTIATION

1986 • 32 citations

Lack of β<sub>2</sub>-Microglobulin on the Surface of Canine Transmissible Venereal Tumor Cells<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1984 • 32 citations

Inhibition of Platelet Aggregation by Monoclonal Antibody Reactive with β₂-Microglobulin Chain of HLA Complex

1984 • 32 citations

Expression of hemopoietic histocompatibility antigens on H-2-loss variants of F1 hybrid lymphoma cells: evidence consistent with trans gene regulation.

1987 • 29 citations

HLA-DR antigens of autologous melanoma and B lymphoblastoid cell lines: differences in glycosylation but not protein structure.

1984 • 29 citations

HLA class II antigens: A comprehensive review of structure and function

1987 • 29 citations

Interferon-mediated enhancement of metastasis. Are MHC antigens involved?

1987 • 29 citations

Hybrid Resistance Controlled by H-2 Region: Correction of Data

1965 • 28 citations

Association in the expression of Kirsten-ras oncogene and the major histocompatibility complex class I antigens in fibrosarcoma tumor cell variants exhibiting different metastatic capabilities.

1987 • 27 citations

REPRESSION OF CLASS I H‐2K,H‐2D ANTIGENS ON GR9 METHYLCHOLANTHRENE‐INDUCED TUMOUR CELL CLONES IS RELATED TO THE LEVEL OF DNA METHYLATION

1986 • 27 citations

Stimulation of genetic resistance to marrow grafts in mice by interferon-alpha/beta.

1985 • 27 citations

Natural killer cells in resistance to virus-infected cells

1982 • 27 citations

Role of MHC class‐i antigens and the CD3 complex in the lysis of autologous human tumours by T‐cell clones

1987 • 27 citations

Control of progression of local tumor and pulmonary metastasis of the 3LL Lewis lung carcinoma by different histocompatibility requirements in mice.

1981 • 26 citations

The c-fos proto-oncogene in murine 3LL carcinoma clones controls the expression of MHC genes.

1988 • 26 citations

Dissociation of HLA heavy chain and light chain (β2 microglobulin) expression on the cell surface of cutaneous malignancies

1983 • 26 citations

Alteration of immunogenicity of xenogenized tumor cells in syngeneic rats by the immune responses to virus-associated antigens produced on immunizing cells.

1983 • 25 citations

Metastatic Capacity of Cloned T10 Sarcoma Cells That Differ in H-2 Expression: Inverse Relationship to Their Immunogenic Potency<xref ref-type="fn" rid="FN2">2</xref>

1985 • 23 citations

Increased or decreased immunogenicity of tumor-associated antigen according to the amount of virus-associated antigen in rat tumor cells infected with friend virus

1982 • 22 citations

Immune control of SV40‐induced tumors in mice

1987 • 21 citations

Effects of biological response modifiers on effector cells with cytotoxic activity against tumors.

1986 • 21 citations

A repulsive view of MHC-restriction

1984 • 20 citations

H-2 negative teratocarcinoma cells become H-2 positive when passaged in genetically resistant host mice.

1981 • 20 citations

Biochemical characterization of proteins that co-purify with class II antigens of the murine MHC.

1988 • 19 citations

Influence of H-2K transfection on susceptibility of fibrosarcoma tumor cells to natural killer (NK) cells

1988 • 19 citations

SEROLOGICAL AND IMMUNOCHEMICAL STUDIES OF H‐2 ALLOSPECIFICITIES ON k36, A SYNGENEIC TUMOUR OF AKR

1980 • 19 citations

Analysis of a defect in the H-2 genes of SV40 transformed C3H fibroblasts that do not express H-2Kk.

1983 • 19 citations

Protective immunity to progressive tumors can be induced by antigen presented on regressor tumors.

1987 • 18 citations

Kirsten murine sarcoma virus abolishes interferon gamma-induced class II but not class I major histocompatibility antigen expression in a murine fibroblast line.

1988 • 18 citations

Immune response to autologous human melanoma: implication of class I and II MHC products

1986 • 17 citations

Syngeneic in vivo passage of the murine BW 5147 lymphoma results in the expression of a stable metastatic phenotype

1988 • 15 citations

Genetic control of the target structures recognized in hybrid resistance

1987 • 15 citations

Inverse relationship in H-2-associated lysis between NK cells and rIL-2-activated killer cells: Evidence from in vitro killing and metastatic experiments

1987 • 13 citations

HLA class II antigens : a comprehensive review of structure and function

1986 • 13 citations

Decreased expression of H-2 antigens following acute measles virus infection

1981 • 12 citations

An immune response against the alloantigens of the 3LL Lewis lung carcinoma prevents the growth of lung metastases, but not of local allografts.

1982 • 12 citations

Differential Susceptibility to Modulation by Recombinant Immune Interferon of HLA-DR and -DQ Antigens Synthesized by Melanoma COLO 38 Cells

1986 • 10 citations

In situ augmentation of class I major histocompatibility antigen expression on immunogenic variants of a spontaneous murine mammary carcinoma.

1987 • 10 citations

MURINE EMBRYONAL CARCINOMA CELLS EXPRESS CLASS I MHC‐LIKE ANTIGENS

1986 • 9 citations

Alterations of class I HLA genes in human colon cancers

1988 • 9 citations

Viral expression and immunogenicity of CBA mammary carcinomas and their hybrid lines with an L-cell derivative (A9HT)

1979 • 8 citations

Imbalanced MHC class II molecule expression at surface of murine B cell lymphomas.

1986 • 8 citations

STRUCTURAL VARIATIONS IN THE H‐2 GENES OF AKR LYMPHOMAS

1986 • 8 citations

Modulation of HLA antigens in response to the binding of epidermal growth factor by A431 cells

1988 • 7 citations

Correlation between classification of human urothelial cell lines and HLA-A,B,C expression

1988 • 6 citations

Interaction of plasma membrane-associated filaments and H-2 histocompatibility antigens before and after induced patching and capping

1987 • 5 citations

GERM CELL TUMOURS OF THE TESTICLE

1986 • 5 citations

Host H-2 genotype regulates the metastatic ability of H-2-associated variants of B16 melanoma: Defense systems screening for absence of self H-2 components by natural killer cells and host-associated homing barrier

1988 • 4 citations

Cytotoxic T cell lysis of H-2-negative murine sarcoma cells

1986 • 2 citations

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