Immune response to autologous human melanoma: implication of class I and II MHC products

Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.

1982 • 2,228 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Natural Killer Cells: Their Roles in Defenses Against Disease

1981 • 1,353 citations

Demonstration of cell‐mediated immunity to human neoplasms of various histological types

1971 • 673 citations

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

1983 • 586 citations

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin

1976 • 478 citations

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

1985 • 410 citations

Tumour-specific Antibodies in Human Malignant Melanoma and their Relationship to the Extent of the Disease

1969 • 396 citations

Cancer immunology: the search for specificity--G. H. A. Clowes Memorial lecture.

1981 • 395 citations

Reversal of Oncogenesis by the Expression of a Major Histocompatibility Complex Class I Gene

1985 • 375 citations

T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor.

1980 • 373 citations

Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2-mediated effects.

1984 • 367 citations

Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

1984 • 359 citations

Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer.

1985 • 358 citations

Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity

1983 • 353 citations

Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets.

1982 • 327 citations

Lymphokine-activated killer cells: A new approach to immunotherapy of cancer

1985 • 314 citations

Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease.

1983 • 264 citations

Striking paucity of HLA-A, B, C and beta 2-microglobulin on human neuroblastoma cell lines.

1983 • 257 citations

Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon.

1984 • 224 citations

Major histocompatibility antigens and mononuclear inflammatory infiltrate in benign nevomelanocytic proliferations and malignant melanoma.

1982 • 193 citations

Immunological Surveillance of Tumors in the Context of Major Histocompatibility Complex Restriction of T Cell Function

1984 • 185 citations

Phenotypic dynamics of tumor progression in human malignant melanoma

1985 • 172 citations

Histocompatibility Antigens on Murine Tumors

1985 • 164 citations

Immunohistochemical analysis of malignant melanomas and nevocellular nevi with monoclonal antibodies to distinct monomorphic determinants of HLA antigens.

1984 • 149 citations

Differential expression of H–2 gene products in tumour cells is associated with their metastatogenic properties

1980 • 146 citations

NK and T cell subsets regulate antibody production by human in vivo antigen-induced lymphoblastoid B cells.

1984 • 145 citations

Clonal analysis of cytotoxic T cell response against human melanoma.

1983 • 138 citations

Reversible induction of natural killer cell activity in cloned murine cytotoxic T lymphocytes

1983 • 134 citations

Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phenotype and specificity.

1984 • 133 citations

Suppressor cell activity of lymphocytes infiltrating human lung and breast tumours

1979 • 131 citations

Heterogeneity in the expression of HLA and tumor-associated antigens by surgically removed and cultured breast carcinoma cells.

1983 • 125 citations

Immunohistologic Characterization of Major Histocompatibility Antigens and Inflammatory Cellular Infiltrate in Human Breast Cancer<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 119 citations

Identification of a clonally restricted 90 kD heterodimer on two human cloned natural killer cell lines. Its role in cytotoxic effector function.

1983 • 115 citations

Clonal analysis of cytotoxic T‐lymphocyte response to autologous human metastatic melanoma

1985 • 107 citations

Modulation of the tumorigenicity of human adenovirus-12-transformed cells by interferon

1985 • 105 citations

Primary but not metastatic human melanomas expressing dr antigens stimulate autologous lymphocytes

1984 • 104 citations

Classes I and II HLA and melanoma-associated antigen expression and modulation on melanoma cells isolated from primary and metastatic lesions.

1986 • 103 citations

Cell lines producing human T-cell lymphoma virus show altered HLA expression

1983 • 102 citations

HLA-DR histocompatibility leukocyte antigens permit cultured human melanoma cells from early but not advanced disease to stimulate autologous lymphocytes.

1984 • 96 citations

Retrovirus-induced changes in major histocompatibility complex antigen expression influence susceptibility to lysis by cytotoxic T lymphocytes.

1985 • 95 citations

Lysis of human solid tumors by autologous cells sensitized in vitro to alloantigens.

1981 • 94 citations

Generation of cytotoxic T lymphocytes to autologous human leukaemia cells by sensitisation to pooled allogeneic normal cells

1978 • 92 citations

Distribution of histocompatibility and leucocyte differentiation antigens in normal human colon and in benign and malignant colonic neoplasms

1984 • 90 citations

Induction of cytotoxic activity in human lymphocytes against autologous and allogeneic melanoma cellsin vitro by culture with interleukin 2

1981 • 88 citations

Inhibition of interleukin 2 production by factors released from tumor cells.

1983 • 87 citations

Selection of strongly immunogenic "tum-" variants from tumors at high frequency using 5-azacytidine.

1984 • 85 citations

Lysis of tumor biopsy cells by autologous T lymphocytes activated in mixed cultures and propagated with T cell growth factor.

1982 • 85 citations

Characteristics of human NK clones: target specificity and phenotype.

1984 • 84 citations

Specific cytotoxicity against autologous tumour and proliferative responses of human lymphocytes grown in interleukin 2

1982 • 83 citations

Lymphokine-Activated Killer (LAK) Cell Phenomenon. IV. Lysis by LAK Cell Clones of Fresh Human Tumor Cells From Autologous and Multiple Allogeneic Tumors

1985 • 83 citations

Specificity of auto‐tumor cytotoxicity exerted by fresh, activated and propagated human t lymphocytes

1982 • 82 citations

Expression of major histocompatibility antigens and nature of inflammatory cellular infiltrate in ovarian neoplasms

1983 • 81 citations

Alien histocompatibility antigens on tumor cells

1979 • 77 citations

Lysis of fresh human tumor cells by autologous large granular lymphocytes from peripheral blood and pleural effusions

1983 • 75 citations

CLONAL ANALYSIS OF T LYMPHOCYTES ISOLATED FROM OVARIAN CARCINOMA ASCITIC FLUID. PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF T-CELL CLONES CAPABLE OF LYSING AUTOLOGOUS CARCINOMA CELLS

1985 • 74 citations

Human tumour antigens defined by cytotoxicity and proliferative responses of cultured lymphoid cells

1982 • 73 citations

Mhc RESTRICTION AND Ir GENES

1982 • 73 citations

Phenotyping of Lesions of Melanocyte Origin With Monoclonal Antibodies to Melanoma-Associated Antigens and to HLA Antigens<xref ref-type="fn" rid="FN2">2</xref>

1984 • 72 citations

Class 1 (unique) tumor antigens of human melanoma. Identification of a 90,000 dalton cell surface glycoprotein by autologous antibody.

1984 • 70 citations

Clonal variation in expression of a human melanoma antigen defined by a monoclonal antibody.

1981 • 69 citations

The inhibition of lymphocyte stimulation by autologous human metastatic melanoma cells correlates with the expression of HLA‐DR antigens on the tumor cells

1984 • 68 citations

Characterisation of breast cancer infiltrates using monoclonal antibodies to human leucocyte antigens

1984 • 66 citations

Tumour-reactive lymphocytes stimulated in mixed lymphocyte and tumour culture

1983 • 63 citations

Characterization of the lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with phytohemagglutinin.

1983 • 62 citations

Changes in Ia-like antigen expression on malignant human cells

1981 • 61 citations

Assignment of human natural killer (NK)‐like cells to the T cell lineage. Single allospecific T cell clones lyse specific or NK‐sensitive target cells via distinct recognition structures

1984 • 60 citations

A cloned human T cell line cytotoxic for autologous and allogeneic B lymphoma cells.

1984 • 57 citations

Heterogeneous expression of melanoma-associated antigens and HLA antigens by primary and multiple metastatic lesions removed from patients with melanoma.

1985 • 57 citations

Heterogeneity of clones from a human metastatic melanoma detected by autologous cytotoxic T lymphocyte clones.

1986 • 57 citations

Correlation between lymphocyte-mediated auto-tumor reactivities and the clinical course

1983 • 55 citations

Human T cell clones exerting multiple cytolytic activities show heterogeneity in susceptibility to inhibition by monoclonal antibodies.

1984 • 54 citations

Accessory cell-dependent selection of specific T-cell functions

1983 • 52 citations

Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy

1983 • 49 citations

Increase in H-2 antigen expression and immunogenicity of BL6 melanoma cells treated with N-methyl-N'-nitronitrosoguanidine.

1985 • 49 citations

Correlation between lymphocyte-mediated auto-tumor reactivities and clinical course

1983 • 46 citations

Lysis of autologous tumor cells by blood lymphocytes tested at the time of surgery

1986 • 46 citations

Antigenic heterogeneity of clones and subclones from human melanoma cell lines demonstrated by a panel of monoclonal antibodies and flow microfluorometry analysis

1984 • 46 citations

Immunoregulatory factors derived from human tumors. II. Partial purification and further immunobiochemical characterization of a human sarcoma-derived immunosuppressive factor expressing HLA-DR and immunoglobulin-related determinants.

1983 • 45 citations

Suppression of the responsiveness of lymphocytes from cancer patients triggered by co-culture with autologous tumor-derived cells.

1983 • 43 citations

Mechanisms by which human gliomas may escape cellular immune attack

1982 • 40 citations

A suppressor lymphokine produced by human T leukemia cell lines. Partial characterization and spectrum of activity against normal and malignant hemopoietic cells.

1986 • 38 citations

In vitro growth of B lymphocytes infiltrating human melanoma tissue by transformation with EBV: evidence for secretion of anti-melanoma antibodies by some transformed cells.

1983 • 35 citations

Lysis of autologous human melanoma cells by in vitro allosensitized peripheral blood lymphocytes

1982 • 34 citations

A clonal analysis of human peripheral blood lymphocytes displaying natural killer‐like activity

1985 • 31 citations

Functional characteristics and differential expression of class II DR, DS, and SB antigens on human melanoma cell lines

1984 • 30 citations

Clonally restricted natural killer-like cytotoxicity displayed by cloned human T cell lines.

1982 • 29 citations

HLA-DR antigens of autologous melanoma and B lymphoblastoid cell lines: differences in glycosylation but not protein structure.

1984 • 29 citations

Serial studies of autologous antibody reactivity to melanoma. Relationship to clinical course and circulating immune complexes.

1985 • 26 citations

DR antigens expressed on tumor cells do not contribute to the blastogenetic response of autologous T cells

1985 • 26 citations

Augmentation of autologous antibody to human melanoma following acid dissociation and ultrafiltration of serum.

1984 • 26 citations

Autologous cellular immune response to primary and metastatic human melanomas and its regulation by DR antigens expressed on tumor cells

1985 • 25 citations

Limitation of differential expression of HLA-A,B,C antigens on choriocarcinoma cell lines by messenger RNA for HLA heavy chain but not by beta 2-microglobulin.

1984 • 24 citations

Human normal CTL clones: Generation and properties

1983 • 22 citations

Tum variants: immunogenic variants obtained by mutagen treatment of tumor cells

1985 • 22 citations

Allostimulation of patients' lymphocytes generates both T and NK-like cells cytotoxic for autologous melanoma

1985 • 22 citations

Natural immunity to tumours – theoretical predictions and biological observations

1985 • 20 citations

The nature of the interaction between suppressor and helper T cells in the response to LDHB.

1983 • 20 citations

In vitro production of human antibody to a tumour-associated foetal antigen

1981 • 17 citations

Prognostic Significance of Leukocyte-Dependent Antibody Activity in Melanoma Patients<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 16 citations

Expression of extra class I major histocompatibility antigens on T-cell acute lymphoblastic leukemia (ALL) lymphoblasts

1985 • 12 citations

Allostimulation-induced tumor cytotoxic cells: from mouse to man

1985 • 12 citations

Activation of lymphocyte anti-tumor responses in man. Towards an understanding of effector cell heterogeneity?

1984 • 9 citations

Murine leukemic cells inhibit IL 2 production by susceptible syngeneic splenocytes.

1985 • 8 citations

Monoclonal Antibodies in Cancer

1986 • 7 citations

Involvement of T3 and T8 molecules in human T cell receptor function. Anti‐T3 or anti‐T8 antibodies do not block the antigen‐dependent activation of a subset of alloreactive cytolytic T cell precursors

1985 • 1 citations