Activation of second-messenger pathways reactivates latent herpes simplex virus in neuronal cultures

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

Recovery of Herpes-Simplex Virus from Human Trigeminal Ganglions

1973 • 687 citations

Down-regulation of protein kinase C is due to an increased rate of degradation

1987 • 442 citations

Herpesvirus hominis : Isolation from Human Trigeminal Ganglion

1972 • 387 citations

Cellular localization of nerve growth factor synthesis by in situ hybridization.

1987 • 345 citations

A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency

1989 • 341 citations

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.

1988 • 312 citations

Human herpesviruses: a consideration of the latent state

1989 • 279 citations

Herpes simplex virus latent phase transcription facilitates in vivo reactivation

1990 • 274 citations

Effect of Forskolin on Voltage-Gated K ⁺ Channels Is Independent of Adenylate Cyclase Activation

1988 • 269 citations

Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection.

1989 • 246 citations

2-Aminopurine Selectively Inhibits the Induction of β-Interferon, c- fos , and c- myc Gene Expression

1988 • 233 citations

Evidence that Neurons Harbor Latent Herpes Simplex Virus

1974 • 232 citations

Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter release

1987 • 204 citations

A herpes simplex virus transcript abundant in latently infected neurons is dispensable for for establishment of the latent state

1988 • 197 citations

Herpes simplex virus latency

1984 • 180 citations

Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases.

1986 • 169 citations

Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse.

1989 • 167 citations

Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro

1987 • 156 citations

Characterization of nerve growth factor-dependent herpes simplex virus latency in neurons in vitro

1988 • 151 citations

The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency.

1991 • 144 citations

Nerve growth factor-dependence of herpes simplex virus latency in peripheral sympathetic and sensory neurons in vitro

1990 • 143 citations

Nerve growth factor regulates both the phosphorylation and steady-state levels of microtubule-associated protein 1.2 (MAP1.2).

1988 • 139 citations

Translational control mediated by eucaryotic initiation factor-2 is restricted to specific mRNAs in transfected cells.

1987 • 127 citations

Nerve growth factor and other agents mediate phosphorylation and activation of tyrosine hydroxylase. A convergence of multiple kinase activities.

1985 • 124 citations

Latent herpes simplex virus type 1 DNA contains two copies of the virion DNA joint region

1985 • 121 citations

Differential down‐regulation of protein kinase C subspecies in KM3 cells

1988 • 115 citations

Stimulatory effects of substance P and nerve growth factor (NGF) on neurite outgrowth in embryonic chick dorsal root ganglia

1978 • 107 citations

Human herpesviruses: a consideration of the latent state.

1989 • 101 citations

Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase.

1989 • 101 citations

A Herpes Simplex Virus Type 1 Mutant Containing a Deletion within Immediate Early Gene 1 Is Latency-competent in Mice

1989 • 95 citations

Cell-free detection and characterization of a novel nerve growth factor-activated protein kinase in PC12 cells.

1987 • 88 citations

A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection

1990 • 87 citations

Latent infection of the peripheral ANS with herpes simplex virus

1975 • 79 citations

Phosphorylation of initiation factor eIF-2 alpha, binding of mRNA to 48 S complexes, and its reutilization in initiation of protein synthesis.

1983 • 67 citations

An antigen encoded by the latency-associated transcript in neuronal cell cultures latently infected with herpes simplex virus type 1

1991 • 64 citations

Purine analogs inhibit nerve growth factor-promoted neurite outgrowth by sympathetic and sensory neurons

1990 • 58 citations

Selective inhibition of responses to nerve growth factor and of microtubule-associated protein phosphorylation by activators of adenylate cyclase.

1986 • 51 citations

Neurobiology of human herpesvirus infections.

1986 • 45 citations

Nerve Growth Factor Affects Cyclic AMP Metabolism, but Not by Directly Stimulating Adenylate Cyclase Activity

1985 • 38 citations

Neurobiology of Amino Acids, Peptides and Trophic Factors

1988 • 36 citations

EFFECTS OF NERVE GROWTH FACTOR ON CYCLIC AMP LEVELS IN EMBRYONIC CHICK DORSAL ROOT GANGLIA FOLLOWING FACTOR DEPRIVATION

1979 • 30 citations

Detection of the latency-associated transcript in neuronal cultures during the latent infection with herpes simplex virus type 1

1991 • 26 citations

Neurobiology of human herpesvirus infections.

1986 • 18 citations

The Biology of Nerve Growth Factor in Vivo

1988 • 5 citations