The T helper 17–regulatory T cell axis in transplant rejection and tolerance

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

2007 • 1,772 citations

Retinoic Acid Imprints Gut-Homing Specificity on T Cells

2004 • 1,460 citations

Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

2007 • 1,443 citations

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

2008 • 1,250 citations

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

2007 • 1,133 citations

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

2008 • 1,118 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

2008 • 897 citations

IL-21 and TGF-β are required for differentiation of human TH17 cells

2008 • 882 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease

2007 • 738 citations

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells

2008 • 715 citations

The development of inflammatory TH-17 cells requires interferon-regulatory factor 4

2007 • 665 citations

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

2008 • 621 citations

Nonredundant roles for Stat5a/b in directly regulating Foxp3

2007 • 561 citations

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

2008 • 520 citations

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3⁺regulatory T cells

2008 • 501 citations

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

2008 • 499 citations

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

2008 • 492 citations

IL-17–producing human peripheral regulatory T cells retain suppressive function

2009 • 471 citations

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

2007 • 434 citations

Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*

2008 • 418 citations

Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells

2008 • 418 citations

Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6

2008 • 349 citations

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells

2008 • 349 citations

Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-6

2008 • 347 citations

Natural and TGF-β–induced Foxp3+CD4+ CD25+ regulatory T cells are not mirror images of each other

2008 • 317 citations

Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced TH17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome

2008 • 316 citations

Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells

2007 • 302 citations

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

2008 • 280 citations

DC activated via dectin‐1 convert Treg into IL‐17 producers

2008 • 262 citations

Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes

2007 • 248 citations

Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3+ Regulatory T Cells

2008 • 218 citations

Activation of retinoic acid receptor‐α favours regulatory T cell induction at the expense of IL‐17‐secreting T helper cell differentiation

2007 • 195 citations

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25− effector T cells

2008 • 190 citations

IL-27 inhibits the development of regulatory T cells via STAT3

2007 • 180 citations

IL-1β and IL-2 convert human Treg into TH17 cells

2009 • 174 citations

IRF-4-Binding Protein Inhibits Interleukin-17 and Interleukin-21 Production by Controlling the Activity of IRF-4 Transcription Factor

2008 • 173 citations

Th1, Th2, and Th17 Effector T Cell-Induced Autoimmune Gastritis Differs in Pathological Pattern and in Susceptibility to Suppression by Regulatory T Cells

2008 • 165 citations

TGF‐β indirectly favors the development of human Th17 cells by inhibiting Th1 cells

2009 • 154 citations

STAT6 Inhibits TGF-β1-mediated Foxp3 Induction through Direct Binding to the Foxp3 Promoter, Which Is Reverted by Retinoic Acid Receptor

2008 • 144 citations

Cutting Edge: Antigen-Specific TGFβ-Induced Regulatory T Cells Suppress Th17-Mediated Autoimmune Disease

2008 • 127 citations

Reprogrammed FoxP3+ T Regulatory Cells Become IL-17+ Antigen-Specific Autoimmune Effectors In Vitro and In Vivo

2008 • 113 citations

The maintenance of human CD4+CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro

2007 • 112 citations

All-transRetinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-γ–Producing T-cells Without Affecting Th17 Cells

2008 • 112 citations

Modulation of T Cell Cytokine Production by Interferon Regulatory Factor-4

2002 • 107 citations

The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells

2008 • 97 citations

Regulatory T cells as therapeutic cells

2008 • 65 citations

Interleukin 17–producing T helper cells in alloimmunity

2008 • 38 citations

Regulatory T cells: hypes and limitations

2008 • 28 citations

IL-17 Production Elicited by Allo-Major Histocompatibility Complex Class II Recognition Depends on CD25posCD4pos T Cells

2008 • 24 citations