Key stages in mammary gland development - Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death

2004 • 4,599 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

1999 • 481 citations

Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution

1997 • 371 citations

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3

2003 • 364 citations

Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression

2003 • 328 citations

Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium

1996 • 292 citations

Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland.

1995 • 238 citations

Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release

2005 • 216 citations

Stromelysin-1 Regulates Adipogenesis during Mammary Gland Involution

2001 • 199 citations

A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland

2003 • 192 citations

Transforming growth factor β3 induces cell death during the first stage of mammary gland involution

2000 • 173 citations

Mammary Gland Involution Is Delayed by Activated Akt in Transgenic Mice

2001 • 165 citations

Accelerated apoptosis in the Timp-3–deficient mammary gland

2001 • 164 citations

Glucocorticoid-induced formation of tight junctions in mouse mammary epithelial cells in vitro.

1992 • 152 citations

A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation

2001 • 151 citations

Accelerated apoptosis in the Timp-3–deficient mammary gland

2001 • 144 citations

Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8

2005 • 130 citations

Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice

2002 • 128 citations

The Genes Induced by Signal Transducer and Activators of Transcription (STAT)3 and STAT5 in Mammary Epithelial Cells Define the Roles of these STATs in Mammary Development

2005 • 125 citations

Deletion of Stat3 Blocks Mammary Gland Involution and Extends Functional Competence of the Secretory Epithelium in the Absence of Lactogenic Stimuli

2002 • 121 citations

ECM degrading proteases and tissue remodelling in the mammary gland

2005 • 116 citations

Lactational competence and involution of the mouse mammary gland require plasminogen

2000 • 112 citations

Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

2005 • 109 citations

Apoptosis regulation in the mammary gland

2004 • 99 citations

C/EBPδ is a crucial regulator of pro-apoptotic gene expression during mammary gland involution

2005 • 97 citations

Milk accumulation triggers apoptosis of mammary epithelial cells.

1997 • 97 citations

Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation

2001 • 83 citations

Leukemia Inhibitory Factor Induces Apoptosis of the Mammary Epithelial Cells and Participates in Mouse Mammary Gland Involution

2003 • 83 citations

Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo.

1999 • 58 citations

Mouse mammary gland involution is associated with cytochrome c release and caspase activation

2001 • 36 citations