Endocytic Traffic in Polarized Epithelial Cells: Role of the Actin and Microtubule Cytoskeleton

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Effects of cytochalasin and phalloidin on actin.

1987 • 1,989 citations

Endocytosis

1997 • 1,263 citations

The Rab5 effector EEA1 is a core component of endosome docking

1999 • 850 citations

Regulated internalization of caveolae.

1994 • 760 citations

Myosin VI is an actin-based motor that moves backwards

1999 • 664 citations

Unconventional Myosins in Cell Movement, Membrane Traffic, and Signal Transduction

1998 • 649 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier

1997 • 502 citations

The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium.

1989 • 498 citations

The Receptor Recycling Pathway Contains Two Distinct Populations of Early Endosomes with Different Sorting Functions

1999 • 446 citations

Actin-Dependent Propulsion of Endosomes and Lysosomes by Recruitment of N-Wasp✪

2000 • 444 citations

Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells.

1993 • 438 citations

Spatial control of coated-pit dynamics in living cells

1999 • 435 citations

Molecular Links between Endocytosis and the Actin Cytoskeleton

2000 • 417 citations

Visualization of Melanosome Dynamics within Wild-Type and Dilute Melanocytes Suggests a Paradigm for Myosin V Function In Vivo

1998 • 407 citations

The Actin Cytoskeleton Is Required for Receptor-mediated Endocytosis in Mammalian Cells

1997 • 394 citations

Association of Rab25 and Rab11a with the Apical Recycling System of Polarized Madin–Darby Canine Kidney Cells

1999 • 391 citations

Regulation of receptor-mediated endocytosis by Rho and Rac

1996 • 386 citations

Actin Assembly Plays a Variable, but not Obligatory Role in Receptor‐Mediated Endocytosis

2000 • 385 citations

Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomes.

1994 • 384 citations

Membrane traffic in polarized epithelial cells

2000 • 384 citations

Pancreatic Beta-Cell Web: Its Possible Role in Insulin Secretion

1972 • 360 citations

Intracellular Transport Using Microtubule-Based Motors

1987 • 356 citations

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

1998 • 353 citations

Actin and fimbrin are required for the internalization step of endocytosis in yeast.

1993 • 346 citations

Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells

1999 • 340 citations

Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor.

1979 • 325 citations

Endocytic vesicles move at the tips of actin tails in cultured mast cells

1999 • 325 citations

Role of coated vesicles, microfilaments, and calmodulin in receptor-mediated endocytosis by cultured B lymphoblastoid cells.

1980 • 315 citations

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

1999 • 315 citations

Microtubule- and motor-dependent fusion in vitro between apical and basolateral endocytic vesicles from MDCK cells

1990 • 299 citations

Syndapin I, a Synaptic Dynamin-binding Protein that Associates with the Neural Wiskott-Aldrich Syndrome Protein

1999 • 299 citations

The emergence of clathrin-independent pinocytic pathways

1995 • 282 citations

Compartmentalized structure of the plasma membrane for receptor movements as revealed by a nanometer-level motion analysis.

1994 • 268 citations

Endocytosis in filter-grown Madin-Darby canine kidney cells.

1989 • 264 citations

Role of Type I Myosins in Receptor-Mediated Endocytosis in Yeast

1996 • 263 citations

Microtubules, membrane traffic, and cell organization

1990 • 229 citations

An Actin-Binding Protein of the Sla2/Huntingtin Interacting Protein 1 Family Is a Novel Component of Clathrin-Coated Pits and Vesicles

1999 • 217 citations

Garrotes, Springs, Ratchets, and Whips: Putting Dynamin Models to the Test

2000 • 215 citations

Chimeric Forms of Furin and Tgn38 Are Transported from the Plasma Membrane to the Trans-Golgi Network via Distinct Endosomal Pathways

1999 • 211 citations

Molecular motors are differentially distributed on Golgi membranes from polarized epithelial cells.

1994 • 208 citations

Regulation of endocytic traffic by Rho family GTPases

2000 • 198 citations

Dictyostelium myosin I double mutants exhibit conditional defects in pinocytosis.

1995 • 198 citations

The Localization of Myosin VI at the Golgi Complex and Leading Edge of Fibroblasts and Its Phosphorylation and Recruitment into Membrane Ruffles of A431 Cells after Growth Factor Stimulation

1998 • 198 citations

Protein trafficking and polarity in kidney epithelium: from cell biology to physiology

1996 • 196 citations

Actin filaments facilitate two steps of endocytosis

1996 • 187 citations

Basolateral to apical transcytosis in polarized cells is indirect and involves BFA and trimeric G protein sensitive passage through the apical endosome

1994 • 186 citations

Definition of Distinct Compartments in Polarized Madin–Darby Canine Kidney (MDCK) Cells for Membrane‐Volume Sorting, Polarized Sorting and Apical Recycling

2000 • 170 citations

Effect of nocodazole on vesicular traffic to the apical and basolateral surfaces of polarized MDCK cells.

1990 • 167 citations

Differential microtubule requirements for transcytosis in MDCK cells.

1990 • 159 citations

Organization and function of the cytoskeleton in polarized epithelial cells: a component of the protein sorting machinery

1994 • 156 citations

Adp-Ribosylation Factor 6 and Endocytosis at the Apical Surface of Madin-Darby Canine Kidney Cells

1999 • 150 citations

Selective modulation of the endocytic uptake of ricin and fluid phase markers without alteration in transferrin endocytosis.

1990 • 145 citations

Apical and Basolateral Endocytic Pathways of MDCK Cells Meet in Acidic Common Endosomes Distinct from a Nearly‐Neutral Apical Recycling Endosome

2000 • 141 citations

Rab17 Regulates Membrane Trafficking through Apical Recycling Endosomes in Polarized Epithelial Cells

1998 • 141 citations

Apical and basolateral endosomes of MDCK cells are interconnected and contain a polarized sorting mechanism.

1996 • 135 citations

Walking on two heads: the many talents of kinesin

2000 • 134 citations

Inhibition of apical but not basolateral endocytosis of ricin and folate in Caco-2 cells by cytochalasin D

1994 • 130 citations

Delivery to lysosomes in the human carcinoma cell line HEp-2 involves an actin filament-facilitated fusion between mature endosomes and preexisting lysosomes.

1995 • 122 citations

Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells.

1994 • 118 citations

Postendocytotic sorting of the ligand for the polymeric immunoglobulin receptor in Madin-Darby canine kidney cells.

1989 • 116 citations

Association of Myosin I Alpha with Endosomes and Lysosomes in Mammalian Cells

1999 • 116 citations

Polarized distribution of actin isoforms in gastric parietal cells.

1995 • 111 citations

Rab17 Localizes to Recycling Endosomes and Regulates Receptor-mediated Transcytosis in Epithelial Cells

1998 • 109 citations

Microtubule perturbation retards both the direct and the indirect apical pathway but does not affect sorting of plasma membrane proteins in intestinal epithelial cells (Caco-2).

1990 • 108 citations

Fluid-Phase Markers in the Basolateral Endocytic Pathway Accumulate in Response to the Actin Assembly-promoting Drug Jasplakinolide

1998 • 104 citations

Both Microtubules and Actin Filaments Are Required for Efficient Postendocytotic Traffic of the Polymeric Immunoglobulin Receptor in Polarized Madin-Darby Canine Kidney Cells

1997 • 100 citations

Endocytosis of superoxide dismutase is required in order for the enzyme to protect hepatocytes from the cytotoxicity of hydrogen peroxide.

1988 • 98 citations

Sorting of Membrane and Fluid at the Apical Pole of Polarized Madin-Darby Canine Kidney Cells

2000 • 98 citations

Sorting Mechanisms Regulating Membrane Protein Traffic in the Apical Transcytotic Pathway of Polarized MDCK Cells

1998 • 97 citations

PKC-ε regulates basolateral endocytosis in human T84 intestinal epithelia: role of F-actin and MARCKS

1999 • 94 citations

Albumin endocytosis in OK cells: dependence on actin and microtubules and regulation by protein kinases

1997 • 89 citations

Role of Actin in Regulated Exocytosis and Compensatory Membrane Retrieval: Insights from an Old Acquaintance

1999 • 86 citations

Cytochalasin B

1973 • 85 citations

Studies in vivo and in vitro on the uptake and degradation of soluble collagen α1(I) chains in rat liver endothelial and Kupffer cells

1985 • 77 citations

Identification of Syntenin as a Protein of the Apical Early Endocytic Compartment in Madin-Darby Canine Kidney Cells

1999 • 76 citations

Both Calmodulin and the Unconventional Myosin Myr4 Regulate Membrane Trafficking Along the Recycling Pathway of MDCK Cells

2000 • 75 citations

Selective regulation of apical endocytosis in polarized Madin-Darby canine kidney cells by mastoparan and cAMP

1994 • 75 citations

Isolation of a temperature‐sensitive variant Chinese hamster ovary cell line with a morphologically altered endocytic recycling compartment

1993 • 73 citations

Identification of cytoskeleton-associated proteins in isolated rat liver endosomes

1997 • 73 citations

The effects of cytochalasin D and phorbol myristate acetate on the apical endocytosis of ricin in polarised Caco-2 cells

1996 • 71 citations

Modulation of Endocytic Traffic in Polarized Madin-Darby Canine Kidney Cells by the Small GTPase RhoA

1999 • 65 citations

The role of cadherin endocytosis in endothelial barrier regulation: involvement of protein kinase C and actin-cadherin interactions.

1998 • 65 citations

Unconventional Myosins: Anchors in the Membrane Traffic Relay

2000 • 65 citations

Selective Alterations in Biosynthetic and Endocytic Protein Traffic in Madin-Darby Canine Kidney Epithelial Cells Expressing Mutants of the Small GTPase Rac1

2000 • 63 citations

Effects of temperature, metabolic inhibitors and some other factors on fluid-phase and adsorptive pinocytosis by rat peritoneal macrophages

1979 • 62 citations

Cytoskeletal disruption in A6 kidney cells: Impact on endo/exocytosis and NaCl transport regulation by antidiuretic hormone

1995 • 59 citations

The subapical compartment and its role in intracellular trafficking and cell polarity

2000 • 52 citations

Membrane motility mediated by unconventional myosin

1994 • 52 citations

Truncated Brush Border Myosin I Affects Membrane Traffic in Polarized Epithelial Cells

2000 • 51 citations

Brush border myosin-I truncated in the motor domain impairs the distribution and the function of endocytic compartments in an hepatoma cell line.

1996 • 46 citations

Effects of colchicine on endocytosis of horseradish peroxidase by rat peritoneal macrophages

1980 • 35 citations

Endocytosis in absorptive cells of cultured human small-intestinal tissue: Effect of cytochalasin B and D

1982 • 26 citations

Do unconventional myosins exert functions in dynamics of membrane compartments?

1992 • 16 citations

Targeting of an Apical Endosomal Protein to Endosomes in Madin–Darby Canine Kidney Cells Requires Two Sorting Motifs

2000 • 11 citations

Role of microfilaments in asialoglycoprotein processing in adult and developing liver

1990 • 8 citations

Microfilament Network Is Needed for the Endocytosis of Water Channels and Not for Apical Membrane Insertion Upon Vasopressin Action

2000 • 6 citations

Microfilament Network Is Needed for the Endocytosis of Water Channels and Not for Apical Membrane Insertion Upon Vasopressin Action

2000 • 1 citations