A Substrate-Based Difluoro Ketone Selectively Inhibits Alzheimer's γ-Secretase Activity

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

1994 • 1,700 citations

Alzheimer's Disease--Genotypes, Phenotype, and Treatments

1997 • 884 citations

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

1993 • 775 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

An improved procedure for the preparation of the Dess-Martin periodinane

1993 • 639 citations

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

1997 • 624 citations

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

1992 • 569 citations

Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities

1996 • 291 citations

New methods and reagents in organic synthesis. 67. A general synthesis of derivatives of optically pure 2-(1-aminoalkyl)thiazole-4-carboxylic acids

1987 • 200 citations

Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors.

1989 • 200 citations

Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

1995 • 148 citations

Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-beta by cathepsin D

1994 • 126 citations

New methods and reagents in organic synthesis, 29, A practical method for the preparation of optically acive N-protected .ALPHA.-amino aldehydes and peptide aldehydes.

1982 • 110 citations

Amyloidogenic Processing of Human Amyloid Precursor Protein in Hippocampal Neurons Devoid of Cathepsin D

1996 • 95 citations

Therapeutic Approaches Related to Amyloid-.beta. Peptide and Alzheimer's Disease

1995 • 81 citations

Candidate .gamma.-Secretases in the Generation of the Carboxyl Terminus of the Alzheimer's Disease .beta.A4 Amyloid: Possible Involvement of Cathepsin D

1995 • 76 citations

Structural requirements for catalysis by chorismate mutase

1989 • 63 citations

Inactivation of calpain by peptidyl fluoromethyl ketones

1992 • 57 citations

Structure-function studies in a series of carboxyl-terminal octapeptide analogs of anaphylatoxin C5a

1992 • 47 citations

Inhibition of chymotrypsin by fluorinated .alpha.-keto acid derivatives

1992 • 28 citations

BRINGING BACK THE MEMORIES

1997 • 2 citations