Expression and ligand-binding function of the integrin ?4?1 (VLA-4) on neural-crest-derived tumor cell lines

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

Integrins.

1991 • 1,369 citations

Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.

1973 • 1,284 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.

1990 • 771 citations

Extracellular Matrix Molecules and their Receptors: Functions in Neural Development

1991 • 726 citations

An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion

1989 • 659 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Coordinate Morphological and Biochemical Interconversion of Human Neuroblastoma Cells<xref ref-type="fn" rid="FN2">2</xref>

1983 • 544 citations

Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α

1989 • 495 citations

Definition of a continuous human cell line derived from neuroblastoma.

1970 • 480 citations

Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism.

1990 • 408 citations

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.

1990 • 400 citations

Structure of the Integrin VLA‐4 and its Cell‐Cell and Cell‐Matrix Adhesion Functions

1990 • 345 citations

Characterization of the cell surface heterodimer VLA-4 and related peptides.

1987 • 340 citations

In Vitro and in Vivo Consequences of VLA-2 Expression on Rhabdomyosarcoma Cells

1991 • 323 citations

Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides [published erratum appears in J Cell Biol 1989 Jun;108(6):following 2546]

1988 • 311 citations

A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).

1990 • 300 citations

Adhesion of Human B Cells to Germinal Centers in Vitro Involves VLA-4 and INCAM-110

1990 • 295 citations

IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1.

1990 • 286 citations

Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel.

1989 • 270 citations

The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.

1989 • 264 citations

The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.

1990 • 251 citations

Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.

1990 • 244 citations

Fibronectin promotes proliferation of naive and memory T cells by signaling through both the VLA-4 and VLA-5 integrin molecules.

1990 • 241 citations

Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines.

1977 • 233 citations

VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin.

1990 • 224 citations

The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: Identification of constant and variable peptides

1983 • 209 citations

Distribution and possible interactions of actin-associated proteins and cell adhesion molecules of nerve growth cones

1989 • 196 citations

An alternative leukocyte homotypic adhesion mechanism, LFA-1/ICAM-1-independent, triggered through the human VLA-4 integrin.

1990 • 180 citations

Monoclonal antibody and synthetic peptide inhibitors of human tumor cell migration.

1990 • 176 citations

Characterization of the human cell line TE671

1989 • 161 citations

Coordinate changes in neuronal phenotype and surface antigen expression in human neuroblastoma cell variants.

1987 • 159 citations

Activation of human CD4 T lymphocytes. Interaction of fibronectin with VLA-5 receptor on CD4 cells induces the AP-1 transcription factor.

1991 • 154 citations

A monoclonal antibody to VLA-4 alpha-chain (CDw49d) induces homotypic lymphocyte aggregation.

1990 • 142 citations

Protein kinase C is involved in laminin stimulation of neurite outgrowth

1989 • 140 citations

Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment.

1988 • 135 citations

Human B lymphocytes define an alternative mechanism of adhesion to fibronectin. The interaction of the alpha 4 beta 1 integrin with the LHGPEILDVPST sequence of the type III connecting segment is sufficient to promote cell attachment.

1990 • 132 citations

The A9 Antigen Associated with Aggressive Human Squamous Carcinoma Is Structurally and Functionally Similar to the Newly Defined Integrin α6β4

1991 • 130 citations

Cell adhesion receptor expression during melanoma progression and metastasis

1991 • 125 citations

Extracellular matrix molecules and cell adhesion molecules induce neurites through different mechanisms.

1990 • 116 citations

Involvement of LFA-1 in lymphoma invasion and metastasis demonstrated with LFA-1-deficient mutants.

1989 • 111 citations

Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage.

1992 • 82 citations

Selective interaction of peripheral and central nervous system cells with two distinct cell-binding domains of fibronectin.

1987 • 82 citations

Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v.

1990 • 80 citations

Human lung tumor-associated antigen identified as an extracellular matrix adhesion molecule.

1991 • 68 citations

The neuronal growth cone as a specialized transduction system

1991 • 67 citations

Recognition of the A chain carboxy-terminal heparin binding region of fibronectin involves multiple sites: two contiguous sequences act independently to promote neural cell adhesion.

1990 • 66 citations

Identification and characterization of two novel lymphocyte function-associated antigens, L24 and L25.

1987 • 66 citations

Lymphocyte Surface Antigen L25 Is a Member of the Integrin Receptor Superfamily

1989 • 49 citations

The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin alpha 6 beta 4.

1991 • 48 citations

Modulation of matrix adhesive responses of human neuroblastoma cells by neighboring sequences in the fibronectins.

1988 • 48 citations

Distinct mechanism of human neuroblastoma cell adhesion to fibronectin

1991 • 6 citations