Tying It All Together: Epigenetics, Genetics, Cell Cycle, and Cancer

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

p53 function and dysfunction

1992 • 1,918 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

Number of CpG islands and genes in human and mouse.

1993 • 986 citations

The essentials of DNA methylation

1992 • 960 citations

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 ^WAF1

1997 • 895 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

The 5-methylcytosine content of DNA from human tumors

1983 • 835 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA

1996 • 790 citations

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

1996 • 784 citations

Spl elements protect a CpG island from de novo methylation

1994 • 713 citations

Suppression of intestinal neoplasia by DNA hypomethylation

1995 • 712 citations

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.

1994 • 597 citations

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

1995 • 561 citations

Reduced genomic 5-methylcytosine content in human colonic neoplasia.

1988 • 491 citations

Histone acetylation: chromatin in action

1997 • 475 citations

Regulation of Proliferating Cell Nuclear Antigen during the Cell Cycle

1989 • 447 citations

Gametic Imprinting in Mammals

1995 • 444 citations

Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.

1994 • 415 citations

DNA methylation errors and cancer.

1996 • 405 citations

DNA methylation and genetic instability in colorectal cancer cells

1997 • 400 citations

Coordinated leading and lagging strand synthesis during SV40 DNA replication in vitro requires PCNA

1988 • 395 citations

Mapping Patterns of CpG Island Methylation in Normal and Neoplastic Cells Implicates Both Upstream and Downstream Regions inde Novo Methylation

1997 • 323 citations

Increased Cytosine DNA-Methyltransferase Activity During Colon Cancer Progression

1993 • 315 citations

Creation of genomic methylation patterns

1996 • 313 citations

DNA Methylation: Molecular Biology and Biological Significance

1993 • 306 citations

Delineation of DNA replication time zones by fluorescence in situ hybridization.

1992 • 305 citations

Association between CpG island methylation and microsatellite instability in colorectal cancer.

1997 • 295 citations

De Novo Methylation of CpG Island Sequences in Human Fibroblasts Overexpressing DNA (Cytosine-5-)-Methyltransferase

1996 • 290 citations

A component of the transcriptional represser MeCP1 shares a motif with DNA methyltransferase and HRX proteins

1997 • 242 citations

DNA Demethylation In Vitro: Involvement of RNA

1996 • 188 citations

DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture.

1986 • 185 citations

Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.

1996 • 138 citations

Formation of methylation patterns in the mammalian genome

1997 • 114 citations

New 5′ Regions of the Murine and Human Genes for DNA (Cytosine-5)-methyltransferase

1996 • 96 citations

Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene

1996 • 90 citations

Epigenetic Gene Inactivation Induced by a Cis-acting Methylation Center

1995 • 71 citations

CpG Islands

1993 • 61 citations

CpG islands in mammalian gene promoters are inherently resistant to de novo methylation

1992 • 59 citations

Ras Induces a General DNA Demethylation Activity in Mouse Embryonal P19 Cells

1995 • 58 citations

Disruption of a Homolog of Trithorax by 11q23 Translocations: Leukemogenic and Transcriptional Implications

1997 • 53 citations

Breakdown of hydrodynamics in the classical 1D Heisenberg model

1992 • 41 citations

Binding of histone H1e-c variants to CpG-rich DNA correlates with the inhibitory effect on enzymic DNA methylation

1995 • 21 citations