A widely expressed transcription factor with multiple DNA sequence specificity,CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Proteins of the Myc Network: Essential Regulators of Cell Growth and Differentiation

1996 • 787 citations

An Exceptionally Conserved Transcriptional Repressor, CTCF, Employs Different Combinations of Zinc Fingers To Bind Diverged Promoter Sequences of Avian and Mammalian c-myc Oncogenes

1996 • 536 citations

Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer.

1990 • 511 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

Myc and Max proteins possess distinct transcriptional activities

1992 • 478 citations

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

1996 • 466 citations

Allelic loss of chromosomes 16q and 10q in human prostate cancer.

1990 • 456 citations

A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene.

1990 • 376 citations

LOSS OF CONSTITUTIONAL HETEROZYGOSITY IN HUMAN CANCER

1991 • 318 citations

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

1994 • 313 citations

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

1990 • 292 citations

Human Cytogenetics: A Practical Approach

1993 • 285 citations

Induction and down-regulation of PLK, a humanserine/threonine kinase expressed in proliferating cells andtumors.

1994 • 278 citations

Inhibition of Transcriptional Regulator Yin-Yang-1 by Association with c-Myc

1993 • 273 citations

CTCF, a Conserved Nuclear Factor Required for Optimal Transcriptional Activity of the Chicken c-myc Gene, Is an 11-Zn-Finger Protein Differentially Expressed in Multiple Forms

1993 • 271 citations

The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region.

1992 • 266 citations

Allelotype of human ovarian cancer.

1991 • 257 citations

Direct role for Myc in transcription initiation mediated by interactions with TFII-I

1993 • 246 citations

Partial deletion of the long arm of chromosome 16 and bone marrow eosinophilia in acute nonlymphocytic leukemia: a new association

1983 • 244 citations

Characterization of chromosomal anomalies in human breast cancer

1990 • 218 citations

A third Wilms' tumor locus on chromosome 16q.

1992 • 201 citations

CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms.

1993 • 198 citations

Transcriptional activation by Myc is under negative control by the transcription factor AP-2.

1995 • 197 citations

Enhanced expression of the c‐myc protooncogene in high‐grade human prostate cancers

1987 • 192 citations

Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivo.

1992 • 182 citations

Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer.

1991 • 177 citations

Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: Primary breakpoints and clinical correlations

1997 • 167 citations

Allelotyping of ductal carcinoma in situ of the breast: deletion of loci on 8p, 13q, 16q, 17p and 17q.

1995 • 162 citations

Overexpression of either c-myc or c-erbB-2/neu proto-oncogenes in human breast carcinomas: correlation with poor prognosis.

1988 • 149 citations

The CEPH Consortium Linkage Map of Human Chromosome 13

1993 • 148 citations

Loss of heterozygosity at chromosome 16q in prostate adenocarcinoma: identification of three independent regions.

1997 • 142 citations

At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer

1994 • 133 citations

Negative Protein 1, Which Is Required for Function of the Chicken Lysozyme Gene Silencer in Conjunction with Hormone Receptors, Is Identical to the Multivalent Zinc Finger Repressor CTCF

1997 • 133 citations

Three distinct commonly deleted regions of chromosome arm 16q in human primary and metastatic prostate cancers

1996 • 128 citations

Loss of heterozygosity on 6q, 16q, and 17p in human central nervous system primitive neuroectodermal tumors.

1991 • 117 citations

Allele loss on chromosome 16q24.2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread.

1994 • 110 citations

Molecular foundations of cancer: New targets for intervention

1995 • 98 citations

An integrated physical map of human chromosome 16.

1995 • 94 citations

Allelotype of endometrial carcinoma.

1994 • 88 citations

Genomic alterations in human breast carcinomas

1990 • 79 citations

Cell-cycle control: POLO-like kinases join the outer circle

1997 • 77 citations

Loss of heterozygosity on chromosome arm 16q in breast cancer metastases

1997 • 76 citations

Deletions on chromosome 16 in primary familial breast carcinomas are associated with development of distant metastases.

1993 • 68 citations

High-resolution cytogenetic-based physical map of human chromosome 16

1992 • 58 citations

Chromosome 16 abnormalities associated with myeloid malignancies

1991 • 54 citations

Identification of multiple breast cancers of multicentric origin by histological observations and distribution of allele loss on chromosome 16q.

1995 • 52 citations

Allelic imbalance study of 16q in human primary breast carcinomas using microsatellite markers

1995 • 51 citations

High frequency of allelic imbalance at chromosome region 16q22‐23 in human breast cancer: Correlation with high pgr and low s phase

1995 • 46 citations

Integration of Transcript and Genetic Maps of Chromosome 16 at Near-1-Mb Resolution: Demonstration of a “Hot Spot” for Recombination at 16p12

1995 • 45 citations

Transcriptional down-regulation of c-myc in human prostate carcinoma cells by the synthetic androgen mibolerone

1992 • 44 citations

Report of the Fourth International Workshop on Human Chromosome 16 Mapping 1995

1996 • 40 citations

Abnormalities of chromosome 16q in myeloid malignancy: 14 new cases and a review of the literature.

1992 • 39 citations

Molecular genetics and chromosomal alterations in prostate cancer

1995 • 34 citations

A PCR-Based Genetic Linkage Map of Human Chromosome 16

1994 • 32 citations

Epithelial‐cadherin Gene Is Not Mutated in Ductal Carcinomas of the Breast

1995 • 28 citations

BRCA1, a gene involved in inherited predisposition to breast and ovarian cancer

1996 • 24 citations

Acute myelogenous leukemia (FAB M1) associated with t(5;16) and eosinophilia

1989 • 24 citations

Chromosome change at 16q22 in nonlymphocytic leukemia: clinical implication on leukemia patients with inv(16) versus del(16).

1988 • 23 citations

Susceptibility Genes for Breast Cancer

1994 • 20 citations

Allelic Loss of Chromosome 16q in Endometrial Cancer: Correlation with Poor Prognosis of Patients and Less Differentiated Histology

1996 • 17 citations

Report of the Third International Workshop on Human Chromosome 16 Mapping 1994

1995 • 16 citations

Early down-regulation of c-myc in dimethylsulfoxide-induced mouse erythroleukemia (MEL) cells is mediated at the P1/P2 promoters.

1993 • 15 citations

The CEPH consortium linkage map of human chromosome 16

1995 • 14 citations

The CEPH consortium linkage map of human chromosome 16.

1995 • 14 citations

Tumor suppressor genes and their alterations in breast cancer

1995 • 14 citations