Alterations of β-adrenoceptor-G-protein-regulated adenylyl cyclase in heart failure

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure

1984 • 3,130 citations

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1982 • 2,259 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.

1990 • 1,151 citations

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1993 • 877 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Forskolin: its biological and chemical properties.

1986 • 566 citations

Beta 1- and beta 2-adrenoceptors in the human heart: properties, function, and alterations in chronic heart failure.

1991 • 555 citations

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.

1988 • 545 citations

Neurohormonal interactions and adaptations in congestive heart failure.

1988 • 540 citations

Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.

1987 • 500 citations

Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site.

1985 • 457 citations

Long-term beta-blockade in dilated cardiomyopathy. Effects of short- and long-term metoprolol treatment followed by withdrawal and readministration of metoprolol.

1989 • 447 citations

Increased beta-receptor density and improved hemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy.

1989 • 429 citations

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

1990 • 393 citations

Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium.

1989 • 370 citations

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

1987 • 356 citations

Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathy.

1990 • 324 citations

INCREASE IN MYOCARDIAL Gi-PROTEINS IN HEART FAILURE

1988 • 315 citations

Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins

1988 • 275 citations

Lipid modifications of G protein subunits.

1991 • 274 citations

Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor

1989 • 271 citations

Adp‐Ribosylation of Guanyl Nucleotide‐Binding Regulatory Proteins by Bacterial Toxins

1988 • 270 citations

Agonist-induced Destabilization of β-Adrenergic Receptor mRNA

1989 • 267 citations

Differences in beta-adrenergic neuroeffector mechanisms in ischemic versus idiopathic dilated cardiomyopathy.

1991 • 254 citations

Tolerance to dobutamine after a 72 hour continuous infusion

1980 • 240 citations

Reduced beta 1 receptor messenger RNA abundance in the failing human heart.

1993 • 237 citations

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

1993 • 234 citations

Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure.

1992 • 217 citations

[45] ADP-ribosylation of membrane components by pertussis and cholera toxin

1985 • 209 citations

Reduction of beta-adrenoceptor density and evaluation of positive inotropic responses in isolated, diseased human myocardium

1988 • 200 citations

Comparison of myocardial catecholamine balance in chronic congestive heart failure and in angina pectoris without failure

1984 • 182 citations

The affinity of (?)-propranolol for ? 1- and ? 1-autoreceptors of human heart

1985 • 175 citations

Additive effects of dobutamine and amrinone on myocardial contractility and ventricular performance in patients with severe heart failure.

1986 • 172 citations

Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.

1988 • 144 citations

Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium.

1991 • 140 citations

Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration.

1991 • 136 citations

Eukaryotic mono(ADP-ribosyl)transferase that ADP-ribosylates GTP-binding regulatory Gi protein.

1988 • 134 citations

Adenylate cyclase: The role of magnesium and other divalent cations

1980 • 130 citations

Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding.

1979 • 122 citations

Radioimmunochemical Quantification of Giα in Right and Left Vehicles from Patients with Ischaemic and Dilated Cardiomyopathy and Predominant Left Ventricular Failure

1994 • 120 citations

Interactions of the bovine brain A1-adenosine receptor with recombinant G protein alpha-subunits. Selectivity for rGi alpha-3.

1991 • 116 citations

Regulation of receptor expression by agonists: transcriptional and post-transcriptional controls

1991 • 103 citations

Genetic analysis of beta-adrenergic receptor internalization and down-regulation.

1985 • 102 citations

Effects of guanyl nucleotides and rhodopsin on ADP-ribosylation of the inhibitory GTP-binding component of adenylate cyclase by pertussis toxin.

1984 • 100 citations

Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain.

1985 • 98 citations

Subsensitivity of the Failing Human Heart to Isoprenaline and Milrinoneo is Related to β-Adrenoceptor Downregulation

1988 • 97 citations

Human cDNA clones for an alpha subunit of Gi signal-transduction protein.

1987 • 91 citations

Agonist Regulation of β-Adrenergic Receptor mRNA

1989 • 89 citations

The effect of pertussis toxin on β‐adrenoceptor responses in isolated cardiac myocytes from noradrenaline‐treated guinea‐pigs and patients with cardiac failure

1992 • 84 citations

Reduced α₁‐ and β₂‐adrenoceptor‐mediated positive inotropic effects in human end‐stage heart failure

1992 • 83 citations

Quantitation of the guanine nucleotide binding regulatory protein Gs in S49 cell membranes using antipeptide antibodies to alpha s.

1988 • 78 citations

Long term beta-adrenoceptor-mediated up-regulation of Gi alpha and G(o) alpha mRNA levels and pertussis toxin-sensitive guanine nucleotide-binding proteins in rat heart.

1992 • 78 citations

Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart.

1993 • 75 citations

Adenine nucleotides promote dissociation of pertussis toxin subunits.

1986 • 72 citations

Distinct down-regulation of cardiac ?1- and ?2-adrenoceptors in different human heart diseases

1991 • 70 citations

Phosphodiesterase Inhibition and Positive Inotropic Effects

1989 • 63 citations

Adenosine Diphosphate Ribosylation of G Proteins by Pertussis and Cholera Toxin in Isolated Membranes. Different Requirements for and Effects of Guanine Nucleotides and Mg²⁺

1987 • 61 citations

Adenine nucleotides directly stimulate pertussis toxin.

1985 • 61 citations

G proteins and cardiovascular disease.

1988 • 57 citations

Cloning and characterization of the human gene for the α‐subunit of G_i2, a GTP‐binding signal transduction protein

1988 • 57 citations

Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gsα in failing human myocardium

1990 • 54 citations

A1-adenosine receptor inhibition of adenylate cyclase in failing and nonfailing human ventricular myocardium.

1991 • 51 citations

Effects of phosphorylation of inhibitory GTP‐binding protein by cyclic AMP‐dependent protein kinase on its ADP‐ribosylation by pertussis toxin, islet‐activating protein

1988 • 44 citations

Reduced Effects of Dopexamine on Force of Contraction in the Failing Human Heart Despite Preserved β2-Adrenoceptor Subpopulation

1989 • 42 citations

Pseudomonas exotoxin A prevents beta-adrenoceptor-induced upregulation of Gi protein alpha-subunits and adenylyl cyclase desensitization in rat heart muscle cells.

1990 • 41 citations

Failure of [32P]ADP-ribosylation by pertussis toxin to determine Giα content in membranes from various human tissues. Improved radioimmunological quantification using the 125I-labelled C-terminal decapeptide of retinal transducin

1991 • 37 citations

Regulation of adenylyl cyclase by noradrenaline and tumour necrosis factor in rat cardiomyocytes

1991 • 37 citations

Beta-adrenergic inotropic responsiveness of patients with heart failure: studies with intracoronary dobutamine infusion.

1987 • 36 citations

A specific βγ-subunit of transducin stimulates ADP-ribosylation of the α-subunit by pertussis toxin

1990 • 34 citations

Identification in human erythrocytes of mono(ADP‐ribosyl) protein hydrolase that cleaves a mono(ADP‐ribosyl) G_i linkage

1990 • 33 citations

Beta 2-adrenergic receptor regulation after transfection into a cell line deficient in the cAMP-dependent protein kinase.

1989 • 27 citations

NADP improves the efficiency of cholera toxin gatalyzed ADP-ribosylation in liver and heart membranes

1986 • 26 citations

Binding of ATP by pertussis toxin and isolated toxin subunits

1990 • 19 citations

Mechanisms of β-Adrenergic Receptor Desensitization

1992 • 16 citations

Endogenous inhibitor of the ADP‐ribosylation of (a) G‐protein(s) as catalyzed by pertussis toxin is present in rat liver

1988 • 15 citations

Adenosine receptors in the human heart: Pharmacological characterization in nondiseased and cardiomyopathic tissue

1993 • 13 citations