Mechanisms of β-Adrenergic Receptor Desensitization

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

1987 • 478 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase.

1983 • 441 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

1990 • 393 citations

Regulation of Adenylyl Cyclase-Coupled beta-Adrenergic Receptors

1988 • 389 citations

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

1985 • 312 citations

Structure of the Adrenergic and Related Receptors

1989 • 300 citations

Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor

1989 • 271 citations

Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels.

1988 • 268 citations

Agonist-induced Destabilization of β-Adrenergic Receptor mRNA

1989 • 267 citations

Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.

1986 • 221 citations

Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization.

1983 • 206 citations

cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.

1989 • 200 citations

Chapter 5 Interactions between photoexcited rhodopsin and light-activated enzymes in rods

1984 • 174 citations

A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide.

1985 • 151 citations

Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.

1988 • 144 citations

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.

1989 • 117 citations

Identification of a specific site required for rapid heterologous desensitization of the beta-adrenergic receptor by cAMP-dependent protein kinase.

1989 • 115 citations

Genetic analysis of beta-adrenergic receptor internalization and down-regulation.

1985 • 102 citations

Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells.

1981 • 96 citations

Agonist-promoted sequestration of the beta 2-adrenergic receptor requires regions involved in functional coupling with Gs.

1989 • 75 citations

Detection and characterization of beta-adrenergic receptors and adenylate cyclase in coated vesicles isolated from bovine brain

1986 • 47 citations

Localization of β-adrenergic receptors in A431 cells in situ. Effect of chronic exposure to agonist

1989 • 47 citations

Molecular Biology of Brain and Endocrine Peptidergic Systems

1988 • 45 citations

Fluorescent localization of the β-adrenergic receptor on DDT-1 cells. Down-regulation by adrenergic agonists

1988 • 30 citations

Desensitization of the mammalian beta-adrenergic receptor: analysis of receptor redistribution on nonlinear sucrose gradients.

1986 • 21 citations

Synthetic segments of the mammalian βAR are preferentially recognized by cAMP-dependent protein kinase and protein kinase C

1987 • 18 citations

Regulation of the Adenylate Cyclase Signalling Pathway: Potential Role for the Phosphorylation of the Catalytic Unit by Protein Kinase A and Protein Kinase C

1988 • 6 citations

Deleted Work

1955 • 0 citations