The effect of pertussis toxin on β‐adrenoceptor responses in isolated cardiac myocytes from noradrenaline‐treated guinea‐pigs and patients with cardiac failure

Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response.

1986 • 564 citations

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.

1988 • 545 citations

INCREASE IN MYOCARDIAL Gi-PROTEINS IN HEART FAILURE

1988 • 315 citations

Mechanism of noradrenaline-induced heterologous desensitization of adenylate cyclase stimulation in rat heart muscle cells: increase in the level of inhibitory G-protein α-subunits

1989 • 117 citations

Contractile responses of isolated adult rat and rabbit cardiac myocytes to isoproterenol and calcium

1988 • 114 citations

Isolated ventricular myocytes from failing and non-failing human heart; the relation of age and clinical status of patients to isoproterenol response

1992 • 107 citations

Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis.

1981 • 96 citations

Selective desensitization of cardiac beta adrenoceptors by prolonged in vivo infusion of catecholamines in rats.

1982 • 94 citations

Studies on Nucleotide and Receptor Regulation of G_iProteins: Effects of Pertussis Toxin

1989 • 65 citations

Reduced positive inotropic effects in diseased human ventricular myocardium

1986 • 61 citations

Isoproterenol sensitivity of isolated cardiac myocytes from rats with monocrotaline-induced right-sided hypertrophy and heart failure

1989 • 52 citations

Evidence against spare or uncoupled β-adrenoceptors in the human heart

1990 • 52 citations

The anti‐adrenergic effect of adenosine and its blockade by pertussus toxin: a comparative study in myocytes isolated from guinea‐pig, rat and failing human hearts

1990 • 43 citations

Species dependence of contraction velocity in single isolated cardiac myocytes.

1990 • 38 citations

Adriamycin cardiomyopathy in the rabbit: alterations in contractile proteins and myocyte function

1990 • 36 citations

Functional and autoradiographic evidence for endothelin 1 receptors on human and rat cardiac myocytes. Comparison with single smooth muscle cells.

1990 • 36 citations

Role of a pertussis toxin-sensitive protein in the modulation of canine Purkinje fiber automaticity.

1988 • 34 citations

Homologous vs. heterologous desensitization of the adenylate cyclase system in heart cells

1988 • 24 citations

Reduced beta-agonist sensitivity in single atrial cells from failing human hearts

1990 • 22 citations

Contraction of cardiac myocytes from noradrenaline-treated rats in response to isoprenaline, forskolin and dibutyryl cAMP

1990 • 20 citations

Comparison between isomyosin pattern and contractility of right ventricular myocytes isolated from rats with right cardiac hypertrophy

1989 • 15 citations

Pertussis toxin reduces the antiadrenergic effect of 2-chloroadenosine on papillary muscle and the direct negative inotropic effect of 2-chloroadenosine on atrium

1987 • 12 citations

Inhibition of the effects of adenosine on force of contraction and the slow calcium inward current by pertussis toxin is associated with myocardial lesions

1988 • 9 citations

Abrupt withdrawal of chronic beta-blockade: Adaptive changes in cyclic AMP and contractility

1981 • 7 citations

Beta-adrenoceptor desensitisation in papillary muscles and myocytes from the hearts of isoprenaline-treated rabbits

1989 • 3 citations

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