Follitropin (FSH) and a phorbol ester stimulate the phosphorylation of the FSH receptor in intact cells.

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency

1978 • 1,103 citations

Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein-Coupled Receptor Family

1989 • 955 citations

A simple procedure for removal of triton X-100 from protein samples

1973 • 857 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

The Testicular Receptor for Follicle Stimulating Hormone: Structure and Functional Expression of Cloned cDNA

1990 • 504 citations

An M2 Muscarinic Receptor Subtype Coupled to Both Adenylyl Cyclase and Phosphoinositide Turnover

1987 • 398 citations

The Lutropin/Choriogonadotropin Receptor… 4 Years Later*

1993 • 394 citations

Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.

1985 • 387 citations

Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells.

1992 • 371 citations

Inositol phosphates: synthesis and degradation.

1988 • 359 citations

Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity.

1991 • 330 citations

Role of phosphorylation in desensitization of the β-adrenoceptor

1990 • 300 citations

Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.

1990 • 270 citations

Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.

1987 • 235 citations

G-protein-coupled receptor kinases

1991 • 219 citations

The thyrotropin receptor 25 years after its discovery: new insight after its molecular cloning.

1992 • 217 citations

Thyrotropin activates both the cyclic AMP and the PIP2casades in CHO cells expressing the human cDNA of TSH receptor

1990 • 184 citations

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

1993 • 178 citations

Internalization and degradation of receptor-bound human choriogonadotropin in Leydig tumor cells. Fate of the hormone subunits.

1982 • 155 citations

A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways.

1992 • 152 citations

Down regulation of specific binding of [20-3H]phorbol 12,13-dibutyrate and phorbol ester-induced differentiation of human promyelocytic leukemia cells.

1981 • 144 citations

The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP.

1989 • 142 citations

Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies.

1992 • 130 citations

Phorbol ester causes desensitization of gonadotropin-responsive adenylate cyclase in a murine Leydig tumor cell line.

1985 • 125 citations

Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase

1993 • 96 citations

Activation by G protein beta gamma subunits of beta-adrenergic and muscarinic receptor kinase.

1993 • 83 citations

Ca2+ mobilization by the LH receptor expressed in Xenopus oocytes independent of 3',5'-cyclic adenosine monophosphate formation: evidence for parallel activation of two signaling pathways.

1992 • 83 citations

The Inositol Phosphate/Diacylglycerol Pathway in MA-10 Leydig Tumor Cells

1989 • 82 citations

Agonist-induced phosphorylation and desensitization of human m2 muscarinic cholinergic receptors in Sf9 insect cells.

1992 • 73 citations

Identification and characterization of a luteinizing hormone/chorionic gonadotropin (LH/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH/CG receptor complementary DNA.

1992 • 66 citations

Truncation of the cytoplasmic tail of the lutropin/choriogonadotropin receptor prevents agonist-induced uncoupling.

1992 • 58 citations

A polyclonal antibody to a synthetic peptide derived from the rat follicle-stimulating hormone receptor reveals the recombinant receptor as a 74-kilodalton protein.

1993 • 56 citations

Attenuation of cAMP-mediated responses in MA-10 Leydig tumor cells by genetic manipulation of a cAMP-phosphodiesterase

1991 • 56 citations

Desensitization of the human beta 1-adrenergic receptor. Involvement of the cyclic AMP-dependent but not a receptor-specific protein kinase.

1991 • 54 citations

Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin receptor expressed in a stably transfected cell line.

1993 • 47 citations

Mutation of a highly conserved acidic residue present in the second intracellular loop of G-protein-coupled receptors does not impair hormone binding or signal transduction of the luteinizing hormone/chorionic gonadotropin receptor.

1993 • 42 citations

Functional effects of protein kinase C-mediated phosphorylation of chick heart muscarinic cholinergic receptors.

1992 • 36 citations

Gonadotropin-Mediated Desensitization in a Murine Leydig Tumor Cell Line Does Not Alter the Regulatory and Catalytic Components of Adenylate Cyclase

1986 • 31 citations

Guanosine Triphosphate Fulfills a Complete and Specific Nucleotide Requirement for Luteinizing Hormone-Induced Desensitization of Pig Ovarian Adenylyl Cyclase*

1989 • 28 citations

Biochemical properties of the agonist-induced desensitization of the follicle-stimulating hormone and luteinizing hormone/chorionic gonadotropin-responsive adenylyl cyclase in cells expressing the recombinant gonadotropin receptors.

1993 • 27 citations

Evidence that the FSH receptor itself is not a calcium channel.

1992 • 21 citations

Identification of a Leydig tumor cell protein that is phosphorylated in response to stimulation with choriogonadotropin or epidermal growth factor.

1993 • 6 citations