Attenuation of cAMP-mediated responses in MA-10 Leydig tumor cells by genetic manipulation of a cAMP-phosphodiesterase

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency

1978 • 1,103 citations

Regulation of Simian Virus 40 Transcription: Sensitive Analysis of the RNA Species Present Early in Infections by Virus or Viral DNA

1979 • 623 citations

Characterization of Several Clonal Lines of Cultured Ley dig Tumor Cells: Gonadotropin Receptors and Steroidogenic Responses*

1981 • 596 citations

Role of phosphorylation in desensitization of the β-adrenoceptor

1990 • 300 citations

Cyclic nucleotide phosphodiesterases: Structure, regulation and drug action

1991 • 176 citations

Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation.

1990 • 174 citations

Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes.

1989 • 171 citations

Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets.

1988 • 146 citations

The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP.

1989 • 142 citations

Regulation of gonadotropin receptors and gonadotropin responses in a clonal strain of Leydig tumor cells by epidermal growth factor.

1981 • 137 citations

Muscarinic cholinergic receptor-mediated activation of phosphodiesterase.

1982 • 133 citations

Lutropin/choriogonadotropin down-regulates its receptor by both receptor-mediated endocytosis and a cAMP-dependent reduction in receptor mRNA.

1991 • 120 citations

Discriminative insulin antagonism of stimulatory effects of various cAMP analogs on adipocyte lipolysis and hepatocyte glycogenolysis.

1985 • 104 citations

Regulation of Phosphodiesterase Synthesis: Requirement for Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1973 • 93 citations

Inhibition of choriogonadotropin-activated steroidogenesis in cultured Leydig tumor cells by the Rp diastereoisomer of adenosine 3′,5′-cyclic phosphorothioate.

1987 • 86 citations

Removal of the surface-bound human choriogonadotropin results in the cessation of hormonal responses in cultured Leydig tumor cells.

1981 • 80 citations

cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase markedly stimulates its catalytic activity.

1988 • 80 citations

Activation of the particulate low Km phosphodiesterase of adipocytes by addition of cAMP-dependent protein kinase.

1988 • 78 citations

Regulation by Follicle-Stimulating Hormone and Dibutyryl Adenosine 3′,5′-Monophosphate of a Phosphodiesterase Isoenzyme of the Sertoli Cell*

1982 • 68 citations

Hormonal Regulation of 3′,5′-Adenosine Monophosphate Phosphodiesterases in Cultured Rat Granulosa Cells*

1984 • 59 citations

Epidermal growth factor activates steroid biosynthesis in cultured Leydig tumor cells without affecting the levels of cAMP and potentiates the activation of steroid biosynthesis by choriogonadotropin and cAMP.

1987 • 52 citations

A mechanism in the control of intracellular cAMP level: the activation of a calmodulin-sensitive phosphodiesterase by a rise of intracellular free calcium

1985 • 48 citations

Effect of Phosphodiesterase Inhibitors on Sertoli Cell Refractoriness: Reversal of the Impaired Androgen Aromatization*

1986 • 34 citations

Regulation of the Differentiated Functions of Leydig Tumor Cells by Epidermal Growth Factor^a

1989 • 27 citations

Rat pineal adenosine cyclic 3',5'-monophosphate phosphodiesterase activity: modulation in vivo by a beta adrenergic receptor.

1975 • 26 citations

Reduced Gonadotropin Responses in a Novel Clonal Strain of Leydig Tumor Cells Established by Transfection of MA-10 Cells with a Mutant Gene of the Type I Regulatory Subunit of the cAMPDependent Protein Kinase

1990 • 26 citations

Inhibition of gonadotropin-responsive adenylate cyclase in MA-10 Leydig tumor cells by epidermal growth factor.

1988 • 26 citations

Characterization of the yeast low Km cAMP-phosphodiesterase with cAMP analogues. Applications in mammalian cells that express the yeast PDE2 gene.

1990 • 21 citations

Epidermal Growth Factor Desensitizes the Gonadotropin-Responsive Adenylyl Cyclase in Membranes Isolated from MA-10 Ley dig Tumor Cells and Luteinized Rat Ovaries*

1990 • 20 citations

Increased cyclic nucleotide phosphodiesterase activity in a mutant S49 lymphoma cell. Characterization and comparison with wild type enzyme activity.

1982 • 17 citations

Regulation by a β-adrenergic receptor of a Ca2+-independent adenosine 3′,5′-(cyclic)monophosphate phosphodiesterase in C6 glioma cells

1981 • 13 citations

Cyclic AMP responses are suppressed in mammalian cells expressing the yeast low Km cAMP-phosphodiesterase gene.

1990 • 13 citations