Evidence for discrete diacylglycerol and phorbol ester activator sites on protein kinase C. Differences in effects of 1-alkanol inhibition, activation by phosphatidylethanolamine and calcium chelation.

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Small-volume extrusion apparatus for preparation of large, unilamellar vesicles

1991 • 1,461 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

Intrinsic curvature hypothesis for biomembrane lipid composition: a role for nonbilayer lipids.

1985 • 599 citations

Lipid activation of protein kinase C.

1991 • 566 citations

The phorbol ester receptor: a phospholipid-regulated protein kinase

1985 • 522 citations

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.

1985 • 471 citations

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family

1988 • 414 citations

Cooperative roles of various membrane phospholipids in the activation of calcium-activated, phospholipid-dependent protein kinase.

1981 • 367 citations

Competitive inhibition by diacylglycerol of specific phorbol ester binding.

1984 • 306 citations

Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP.

1985 • 274 citations

Protein kinase C contains two phorbol ester binding domains.

1991 • 234 citations

Inhibition of protein kinase C by alcohols and anaesthetics

1993 • 230 citations

The nature of protein kinase C activation by physically defined phospholipid vesicles and diacylglycerols.

1985 • 228 citations

Modification by diacylglycerol of the structure and interaction of various phospholipid bilayer membranes

1986 • 225 citations

Diacylglycerols, lysolecithin, or hydrocarbons markedly alter the bilayer to hexagonal phase transition temperature of phosphatidylethanolamines

1985 • 224 citations

A thermodynamic model of the lamellar to inverse hexagonal phase transition of lipid membrane-water systems

1984 • 209 citations

Autophosphorylation of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 183 citations

The modulation of protein kinase C activity by membrane lipid bilayer structure.

1994 • 163 citations

[24] Assay and purification of protein kinase C

1986 • 159 citations

Complexities of the Protein Kinase C Pathway

1991 • 131 citations

Diacylglycerol causes major structural transitions in phospholipid bilayer membranes

1984 • 121 citations

Properties of membrane-inserted protein kinase C

1988 • 119 citations

High Cooperativity, Specificity, and Multiplicity in the Protein Kinase C-Lipid Interaction

1989 • 116 citations

Differential irreversible insertion of protein kinase C into phospholipid vesicles by phorbol esters and related activators.

1992 • 101 citations

Importance of phosphatidylethanolamine for association of protein kinase C and other cytoplasmic proteins with membranes

1992 • 100 citations

Effects of lipid packing on polymorphic phase behavior and membrane properties.

1989 • 100 citations

Aminoacridines, potent inhibitors of protein kinase C.

1988 • 96 citations

Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding

1992 • 94 citations

Differences in the effects of phorbol esters and diacylglycerols on protein kinase C

1989 • 87 citations

Mechanism of protein kinase C activation by phosphatidylinositol 4,5-bisphosphate

1991 • 84 citations

Constitutive activity of membrane-inserted protein kinase C

1988 • 83 citations

Determination of the phase behaviour of phosphatidylethanolamine admixed with other lipids and the effects of calcium chloride: implications for protein kinase C regulation

1988 • 82 citations

Purification and characterization of protein kinase C .epsilon. from rabbit brain

1992 • 77 citations

Enzymic and physical characterization of diacylglycerol-phosphatidylcholine interactions in bilayers and monolayers

1989 • 67 citations

Properties of the protein kinase C-phorbol ester interaction

1989 • 59 citations

Hexagonal phase forming propensity detected in phospholipid bilayers with fluorescent probes

1992 • 59 citations

The adriamycin-iron(III) complex is a potent inhibitor of protein kinase C

1989 • 56 citations

Protein kinase C penetration into lipid bilayers

1990 • 41 citations

Phorbol ester and 1,2‐diolein are not fully equivalent activators of protein kinase C in respect to phosphorylation of membrane proteins in vitro

1986 • 37 citations

The role of hydrophobic interactions in the phospholipid-dependent activation of protein kinase C.

1988 • 36 citations

Application of high-pressure to subfractionate membrane protein-lipid complexes: A case study of protein kinase C

1990 • 25 citations

Circular dichroism analysis of ligand-induced conformational changes in protein kinase C. Mechanism of translocation of the enzyme from the cytosol to the membranes and its implications

1993 • 17 citations

Mixed micellar assay for phorbol ester binding

1987 • 14 citations