Inhibition of protein kinase C by alcohols and anaesthetics

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Partition coefficients and their uses

1971 • 4,444 citations

Zur Theorie der Alkoholnarkose

1899 • 1,008 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain.

1977 • 865 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Do general anaesthetics act by competitive binding to specific receptors?

1984 • 559 citations

Molecular mechanisms of general anaesthesia

1982 • 429 citations

Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects

1985 • 236 citations

The Nature of The Site of General Anesthesia

1985 • 205 citations

Degenerate perturbations of protein structure as the mechanism of anaesthetic action

1978 • 193 citations

The molecular mechanisms of anaesthesia

1977 • 174 citations

The effect of two inhalation anesthetics of the order of spin-labeled phospholipid vesicles

1973 • 169 citations

Zur Theorie der Alkoholnarkose

1901 • 165 citations

Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site

1989 • 160 citations

[24] Assay and purification of protein kinase C

1986 • 159 citations

The lipid binding, regulatory domain of protein kinase C. A 32-kDa fragment contains the calcium- and phosphatidylserine-dependent phorbol diester binding activity.

1986 • 140 citations

A study of the effect of general anesthetics on lipid-protein interactions in acetylcholine receptor-enriched membranes from Torpedo nobiliana [as measured by] using nitroxide spin-labels

1990 • 62 citations

Membrane interactions with general and local anaesthetics: A review of molecular hypotheses of anaesthesia

1983 • 60 citations

The dynamics of lipid motion in sarcoplasmic reticulum membranes determined by steady-state and time-resolved fluorescence measurements on 1,6-diphenyl-1,3,5-hexatriene and related molecules

1984 • 50 citations

Modulation of the general anesthetic sensitivity of a protein: a transition between two forms of firefly luciferase.

1991 • 48 citations

Effects of general anesthetics on the bacterial luciferase enzyme from Vibrio harveyi: an anesthetic target site with differential sensitivity

1990 • 48 citations

Inhibitory Effect of Barbiturates and Local Anaesthetics on Protein Kinase C Activation

1990 • 45 citations

Volatile anesthetics stimulate the phorbol ester evoked neurotransmitter release from PC12 cells through an increase of the cytoplasmic Ca2+ ion concentration

1991 • 28 citations

A Low-Fat Theory of Anesthesia

1992 • 21 citations

Inhibition of Protein Kinase C by Local Anesthetics

1991 • 13 citations

The Nicotinic Acetylcholine Receptor in Its Membrane Environment^a

1991 • 12 citations