Production of Superoxide by Phagocytic Leukocytes: A Paradigm for Stimulus-Response Phenomena

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

The Metabolic Basis of Inherited Disease.

1983 • 2,885 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Endocytosis

1977 • 1,275 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

Active Oxygen Species and the Functions of Phagocytic Leukocytes

1980 • 1,124 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Characterization of membrane proteins in detergent solutions

1976 • 853 citations

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

1975 • 749 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

The polyphosphoinositide phosphodiesterase of erythrocyte membranes

1981 • 614 citations

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1982 • 600 citations

Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes.

1977 • 541 citations

Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?

1983 • 471 citations

The concept of lipid domains in membranes.

1982 • 466 citations

Localization of NADH oxidase on the surface of human polymorphonuclear leukocytes by a new cytochemical method.

1975 • 464 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.

1986 • 378 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.

1985 • 356 citations

Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages

1984 • 335 citations

Novel cytochrome b system in phagocytic vacuoles of human granulocytes

1978 • 335 citations

Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels

1984 • 334 citations

Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor.

1985 • 334 citations

Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system.

1985 • 315 citations

Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme.

1985 • 300 citations

Hormone-induced redistribution of calcium-activated phospholipid-dependent protein kinase in pituitary gonadotrophs.

1985 • 296 citations

Phospholipid-sensitive Ca2+-dependent protein kinase from heart. II. Substrate specificity and inhibition by various agents.

1982 • 290 citations

Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein

1985 • 286 citations

The Molecular Basis of Communication within the Cell

1985 • 282 citations

Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.

1985 • 281 citations

Release of Gelatinase from a Novel Secretory Compartment of Human Neutrophils

1982 • 276 citations

Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux.

1984 • 272 citations

Subcellular localization of the superoxide-forming enzyme in human neutrophils.

1979 • 268 citations

Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate.

1984 • 266 citations

Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils.

1984 • 262 citations

The influence of dolichol, dolichol esters, and dolichyl phosphate on phospholipid polymorphism and fluidity in model membranes.

1985 • 259 citations

Characteristics of the cofactor requirements for the superoxide-generating NADPH oxidase of human polymorphonuclear leukocytes

1981 • 251 citations

Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils.

1985 • 250 citations

Receptors for human γG Globulin on human neutrophils

1970 • 250 citations

Leukotriene B4 is a complete secretagogue in human neutrophils: A kinetic analysis

1982 • 237 citations

Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells

1985 • 234 citations

Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin.

1984 • 230 citations

Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst

1981 • 229 citations

Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes

1985 • 229 citations

Human serum albumin. Spectroscopic studies of binding and proximity relationships for fatty acids and bilirubin.

1979 • 228 citations

Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes.

1984 • 225 citations

Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms.

1983 • 225 citations

Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes.

1983 • 223 citations

Effect of phorbol 12-myristate 13-acetate and its analogue 4 alpha-phorbol 12,13-didecanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils.

1984 • 221 citations

Activation of a NADPH Oxidase From Horse Polymorphonuclear Leukocytes in a Cell- Free System

1984 • 221 citations

Phorbol 12-myristate 13-acetate activates rabbit neutrophils without an apparent rise in the level of intracellular free calcium

1983 • 217 citations

Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C.

1985 • 216 citations

Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor.

1986 • 215 citations

cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils.

1981 • 208 citations

Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells.

1985 • 197 citations

Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms

1984 • 194 citations

Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase.

1985 • 193 citations

Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.

1985 • 192 citations

Chemotactic factor causes rapid decreases in phosphatidylinositol,4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils

1983 • 188 citations

Subcellular localization of the human neutrophil NADPH oxidase. b-Cytochrome and associated flavoprotein.

1984 • 187 citations

Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation.

1985 • 182 citations

Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: Possible role of the “G proteins” in calcium mobilization

1984 • 180 citations

Purification of phosphatidylinositol-specific phospholipase C from rat liver.

1981 • 180 citations

Stimulus response coupling in the human neutrophil. I. Kinetic analysis of changes in calcium permeability.

1984 • 177 citations

Phosphoinositide turnover provides a link in stimulus—response coupling

1985 • 175 citations

Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.

1985 • 175 citations

Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate

1984 • 171 citations

Fluoride-mediated activation of the respiratory burst in human neutrophils. A reversible process.

1979 • 170 citations

Production of phosphoinositide-derived messengers

1984 • 163 citations

The Metabolic Basis of Phagocytosis

1961 • 159 citations

Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin.

1985 • 159 citations

Modulation of phosphatidylinositol-specific phospholipase C activity by phospholipid interactions, diglycerides, and calcium ions.

1982 • 158 citations

Intracellular pH modulates the generation of superoxide radicals by human neutrophils.

1985 • 156 citations

The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin.

1985 • 155 citations

Guanosine 5'-O-thiotriphosphate stimulates phospholipase C activity in plasma membranes of rat hepatocytes.

1985 • 154 citations

Secretagogue-induced phosphoinositide metabolism in human leucocytes

1984 • 152 citations

Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate.

1984 • 145 citations

Surface‐reactive stimuli selectively increase protein phosphorylation in human neutrophils

1981 • 134 citations

Dependence on Ca2+ of the activities of phosphatidylinositol 4,5-bisphosphate phosphodiesterase and inositol 1,4,5-trisphosphate phosphatase in smooth muscles of the porcine coronary artery

1985 • 131 citations

Superoxide release by neutrophils: Synergistic effects of a phorbol ester and a calcium ionophore

1984 • 129 citations

A possible role of protein kinase C in signal-induced lysosomal enzyme release

1983 • 128 citations

Phagocytosis–Past and Future

1982 • 128 citations

Effects of Phorbol Myristate Acetate on the Metabolism and Ultrastructure of Neutrophils in Chronic Granulomatous Disease

1974 • 127 citations

Mechanism of the superoxide-producing oxidase of neutrophils. O2 is necessary for the fast reduction of cytochrome b-245 by NADPH

1985 • 126 citations

Role of cell surface contact in the kinetics of superoxide production by granulocytes.

1983 • 126 citations

Differential activation of phosphatidylinositol deacylation and a pathway via diphosphoinositide in macrophages responding to zymosan and ionophore A23187.

1984 • 123 citations

Receptor-mediated regulation of superoxide production in human neutrophils stimulated by phorbol myristate acetate.

1981 • 121 citations

Signal transduction and ligand-receptor dynamics in the human neutrophil. Transient responses and occupancy-response relations at the formyl peptide receptor.

1985 • 120 citations

Stimulation of fluorescence in a small contact region between rat basophil leukemia cells and planar lipid membrane targets by coherent evanescent radiation.

1982 • 119 citations

The association of FAD with the cytochrome b–245 of human neutrophils

1982 • 112 citations

Functional relationship of the cytochrome b to the superoxide-generating oxidase of human neutrophils.

1982 • 109 citations

Studies on the Role of Phospholipids in Phagocytosis

1966 • 106 citations

The NADPH-dependent O-.2-generating oxidase from human neutrophils.

1983 • 105 citations

Redistribution of protein kinase C activity in human monocytes: correlation with activation of the respiratory burst.

1985 • 101 citations

Changes in phosphatidylinositol and phosphatidic acid in stimulated human neutrophils

1983 • 101 citations

Identification of ubiquinone-50 in human neutrophils and its role in microbicidal events.

1982 • 98 citations

Superoxide-forming NADPH oxidase preparation of pig polymorphonuclear leucocyte

1982 • 97 citations

Purification and partial characterization of the b-type cytochrome from human polymorphonuclear leukocytes.

1985 • 97 citations

Retinal inhibits TPA activated, calcium-dependent, phospholipid-dependent protein kinase (“C” kinase)

1983 • 96 citations

Retinoid inhibition of superoxide anion radical production by human polymorphonuclear leukocytes stimulated with tumor promoters

1980 • 95 citations

Superoxide production of human polymorphonuclear leukocytes stimulated by leukotriene B4

1984 • 95 citations

The Calcium‐Dependent Phosphatidylinositol‐Phosphodiesterase of Rat Brain

1979 • 92 citations

Subcellular localization of cytochrome b and ubiquinone in a tertiary granule of resting human neutrophils and evidence for a proton pump ATPase.

1984 • 90 citations

Modulation of protein kinase C activity and [3H]phorbol 12,13-dibutyrate binding by various tumor promoters in mouse brain cytosol.

1985 • 88 citations

Purification of cytochrome b-245 from human neutrophils

1984 • 88 citations

The Ca2+-activated polyphosphoinositide phosphodiesterase of human and rabbit neutrophil membranes

1984 • 85 citations

Regulation of the oxidative response of human granulocytes to chemoattractants. No evidence for stimulated traffic of redox enzymes between endo and plasma membranes.

1985 • 85 citations

Release of superoxide and change in morphology by neutrophils in response to phorbol esters: antagonism by inhibitors of calcium-binding proteins.

1985 • 83 citations

Characterization of formylmethionyl-leucyl-phenylalanine stimulation of inositol trisphosphate accumulation in rabbit neutrophils.

1985 • 82 citations

Pertussis toxin inhibits chemotactic factor‐induced phospholipase C stimulation and lysosomal enzyme secretion in rabbit neutrophils

1985 • 81 citations

Receptor-mediated Modulation of Human Monocyte, Neutrophil, Lymphocyte, and Platelet Function by Phorbol Diesters

1982 • 80 citations

Inositol phosphate formation in fMet-Leu-Phe-stimulated human neutrophils does not require an increase in the cytosolic free Ca2+ concentration

1985 • 80 citations

Comparative aspects of oxidative metabolism of neutrophils from human blood and guinea pig peritonea: Magnitude of the respiratory burst, dependence upon stimulating agents, and localization of the oxidases

1980 • 79 citations

Cytochrome b translocation to human neutrophil plasma membranes and superoxide release. Differential effects of N-formylmethionylleucylphenylalanine, phorbol myristate acetate, and A23187.

1985 • 78 citations

The Binding of Reduced Nicotinamide Adenine Dinucleotide-Cytochrome b 5 Reductase to Hepatic Microsomes

1974 • 78 citations

Phorbol myristate acetate receptors in human polymorphonuclear neutrophils.

1985 • 75 citations

Cytochrome b558 from (bovine) granulocytes. Partial purification from Triton X-114 extracts and properties of the isolated cytochrome.

1984 • 75 citations

Calmodulin-dependents stimulation of the NADPH oxidase of human neutrophils

1982 • 75 citations

The effect of free fatty acids on the thermotropic phase transition of dimyristoyl glycerophosphocholine

1978 • 75 citations

Production of superoxide and hydrogen peroxide by an NADH-oxidase in guinea pig polymorphonuclear leukocytes. Modulation by nucleotides and divalent cations.

1979 • 73 citations

Protein kinase C phosphorylates a component of NADPH oxidase of neutrophils

1985 • 71 citations

Protein kinase C: Rapid enzyme purification and substrate-dependence of the diacylglycerol effect

1984 • 70 citations

Relation of human neutrophil phorbol ester receptor occupancy and NADPH- oxidase activity

1982 • 69 citations

Phosphorylation of cytosolic proteins by resting and activated human neutrophils

1984 • 69 citations

Identification of the polymorphonuclear leukocyte C5a receptor.

1985 • 67 citations

Activation of nadph oxidase of human neutrophils. Potentiation of chemotactic peptide by a diacylglycerol

1984 • 63 citations

Cytochrome b, flavins, and ubiquinone-50 in enucleated human neutrophils (polymorphonuclear leukocyte cytoplasts).

1984 • 62 citations

Isolation of plasma membrane from human neutrophils and determination of cytochrome b and quinone content

1981 • 61 citations

Enhancement by Ca2+ or Mg2+ of catalytic activity of the superoxide-producing NADPH oxidase in membrane fractions of human neutrophils and monocytes.

1985 • 57 citations

myo-Inositol 1,4,5-trisphosphate stimulates protein phosphorylation in saponin-permeabilized human platelets.

1984 • 56 citations

Initial Characterization of the Calcium Channel Activated by the Crosslinking of the Receptors for Immunoglobulin E *

1986 • 55 citations

A New Cytochrome in Neutrophilic Granules of Rabbit Leucocyte

1966 • 55 citations

Evidence for N‐formyl chemotactic peptide‐stimulated GTPase activity in human neutrophil homogenates

1984 • 53 citations

Con-A-stimulated superoxide production by granulocytes: reversible activation of NADPH oxidase

1982 • 51 citations

Changes in the subcellular distribution of the cytochrome b-245 on stimulation of human neutrophils

1984 • 51 citations

Regulation of oxygen metabolism in human granulocytes: relationship between stimulus binding and oxidative response using plant lectins as probes

1980 • 51 citations

NAD(P)H-dependent superoxide production by phagocytic vesicles from guinea pig and human granulocytes.

1980 • 51 citations

Synergism between phorbol ester and A23187 in Superoxide production by neutrophils

1984 • 50 citations

Composition of partially purified NADPH oxidase from pig neutrophils

1984 • 48 citations

Activation of the human neutrophil NADPH oxidase results in coupling of electron carrier function between ubiquinone-10 and cytochrome b559.

1985 • 48 citations

Ubiquinone content and respiratory burst activity of latex-filled phagolysosomes isolated from human neutrophils and evidence for the probable involvement of a third granule.

1983 • 46 citations

Effect of retinol and retinoic acid on permeability, electrical resistance and phase transition of lipid bilayers

1982 • 42 citations

Superoxide production by an unusual aldehyde oxidase in guinea pig granulocytes. Characterization and cytochemical localization.

1981 • 42 citations

Initial characterization of the calcium channel activated by the cross-linking of the receptors for immunoglobulin E.

1984 • 41 citations

Effect of Unsaturated Fatty Acids and Ca2+ on Phosphatidylinositol Synthesis and Breakdown

1982 • 39 citations

Simultaneous demonstration of phagocytosis-connected oxygen consumption and corresponding NAD(P)H oxidase activity: Direct evidence for NADPH as the predominant electron donor to oxygen in phagocytizing human neutrophils

1981 • 38 citations

Polymyxin B inhibits phorbol 12‐myristate 13‐acetate, but not chemotactic factor, induced effects in rabbit neutrophils

1985 • 38 citations

Retinoids stimulate the release of superoxide by neutrophils and change their morphology

1986 • 35 citations

The subcellular localization of ubiquinone in human neutrophils

1983 • 34 citations

Studies on the Nature and Activation of O₂⁻-forming NADPH Oxidase of Leukocytes. Identification of a Phosphorylated Component of the Active Enzyme

1985 • 33 citations

Failure to Detect Superoxide in Human Neutrophils Stimulated With Latex Particles(21)

1983 • 32 citations

Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates.

1984 • 29 citations

Diverse involvements of Ni protein in superoxide anion production in polymorphonuclear leukocytes depending on the type of membrane stimulants

1985 • 28 citations

Protein phosphorylation in intact pig leukocytes

1984 • 26 citations

The O2− generating oxidoreductase of human neutrophils: Evidence of an obligatory requirement for calcium and magnesium for expression of catalytic activity

1983 • 20 citations

Metabolic stimulation of polymorphonuclear leucocytes: Effects of tetravalent and divalent concanavalin A

1978 • 15 citations

The energy metabolism of the leukocyte. IX. Changes in the concentration of the coenzymes NAD, NADH, NADP, and NADPH in polymorphonuclear leukocytes during phagocytosis of Staphylococcus albus and due to the action of phospholipase C.

1977 • 15 citations

The Energy Metabolism of the Leukocyte

1977 • 14 citations

Oncogene linked to cell regulatory system

1984 • 10 citations