The multidrug resistance phenotype

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

1985 • 545 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.

1985 • 410 citations

Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers.

1983 • 384 citations

The cell biology of multiple drug resistance

1987 • 340 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

P-glycoprotein in human sarcoma: evidence for multidrug resistance.

1987 • 261 citations

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1986 • 255 citations

Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors.

1983 • 250 citations

Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.

1984 • 231 citations

Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).

1987 • 229 citations

DETECTION OF A MULTIDRUG RESISTANT PHENOTYPE IN ACUTE NON-LYMPHOBLASTIC LEUKAEMIA

1987 • 223 citations

Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multi-drug resistant human lung cancer cell line

1987 • 205 citations

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

1987 • 198 citations

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 173 citations

The effect of verapamil on the pharmacokinetics of adriamycin

1986 • 146 citations

Promotion by verapamil of vincristine responsiveness in tumor cell lines inherently resistant to the drug.

1983 • 119 citations

Adriamycin-stimulated hydroxyl radical formation in human breast tumor cells

1987 • 110 citations

In vivo resistance towards anthracyclines, etoposide, and cis-diamminedichloroplatinum(II).

1982 • 109 citations

Increase in Nonspecific Adsorptive Endocytosis in Anthracycline-and Vinca Alkaloid-Resistant Ehrlich Ascites Tumor Cell Lines2

1987 • 87 citations

Increased plasma membrane traffic in daunorubicin resistant P388 leukaemic cells. Effect of daunorubicin and verapamil

1987 • 79 citations

Adriamycin resistance in HL60 cells and accompanying modification of a surface membrane protein contained in drug-sensitive cells.

1987 • 55 citations

Possible link between the intrinsic drug resistance of colon tumors and a detoxification mechanism of intestinal cells.

1988 • 47 citations

Drug resistance in human lung cancer cell lines: Cross-resistance studies and effects of the calcium transport blocker, verapamil

1986 • 46 citations

Potentiation of doxorubicin cytotoxicity by the calcium antagonist bepridil in anthracycline-resistant and-sensitive cell lines

1987 • 40 citations

Chromosomal localization of three genes coamplified in the multidrug-resistant CHRC5 Chinese hamster ovary cell line.

1987 • 38 citations

Amiodarone is more efficient than verapamil in reversing resistance to anthracyclines in tumour cells

1987 • 34 citations

The effect of insulin on steroid metabolism in isolated rat hepatocytes

1987 • 11 citations