A<scp>d</scp>-Amino Acid Peptide Inhibitor of NF-κB Nuclear Localization Is Efficacious in Models of Inflammatory Disease

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Clinicopathologic study of dextran sulfate sodium experimental acute colitis

1998 • 1,955 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Intercellular Trafficking and Protein Delivery by a Herpesvirus Structural Protein

1997 • 962 citations

Galactosamine-induced sensitization to the lethal effects of endotoxin.

1979 • 940 citations

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

1995 • 923 citations

Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice

1996 • 839 citations

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

1996 • 760 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α

1998 • 759 citations

Isolation of a protein that is essential for the first step of nuclear protein import

1994 • 710 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

An improved rosetting assay for detection of human T lymphocytes

1974 • 674 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Nuclear factor kappa B, a mediator of lipopolysaccharide effects

1993 • 476 citations

Synthetic peptides as nuclear localization signals

1986 • 472 citations

Sequence requirements for synthetic peptide-mediated translocation to the nucleus.

1989 • 413 citations

Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis

1995 • 392 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

1996 • 340 citations

Purification of a Ran-interacting protein that is required for protein import into the nucleus.

1994 • 318 citations

Nuclear protein import

1997 • 296 citations

Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import

1996 • 253 citations

Nuclear localization signals (NLS).

1993 • 249 citations

Interaction of the Immunosuppressant Deoxyspergualin with a Member of the Hsp70 Family of Heat Shock Proteins

1992 • 232 citations

Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50.

1998 • 187 citations

Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes.

1994 • 184 citations

Regulation of transcription factor localization: fine-tuning of gene expression

1996 • 177 citations

Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins.

1992 • 176 citations

Differential Expression and Sequence-specific Interaction of Karyopherin α with Nuclear Localization Sequences

1997 • 168 citations

Regulation of NF-κB, AP-1, NFAT, and STAT1 Nuclear Import in T Lymphocytes by Noninvasive Delivery of Peptide Carrying the Nuclear Localization Sequence of NF-κB p50

1998 • 157 citations

Role of Oxidative Stress in the Action of Vanadium Phosphotyrosine Phosphatase Inhibitors

1997 • 138 citations

The Inflammatory Cytokines

1996 • 119 citations

Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.

1989 • 117 citations

Toward the molecular dissection of protein import into nuclei

1996 • 112 citations

Identification of four nuclear transport signal-binding proteins that interact with diverse transport signals.

1989 • 101 citations

Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.

1995 • 92 citations

Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-1, NF-IL6 and NF-kappa B) which are involved in IL-6 regulation.

1996 • 85 citations

Activation of nuclear factor kappa B in Crohn's disease

1998 • 79 citations

Deoxyspergualin inhibits kappa light chain expression in 70Z/3 pre-B cells by blocking lipopolysaccharide-induced NF-kappa B activation.

1995 • 77 citations

Biologic therapy for inflammatory bowel disease

1997 • 58 citations

Identification of Four Nuclear Transport Signal-Binding Proteins That Interact with Diverse Transport Signals

1989 • 45 citations

Cellular import of functional peptides to block intracellular signaling

1997 • 45 citations

Comparison of diverse transport signals in synthetic peptide-induced nuclear transport

1990 • 43 citations

Enhancement of endotoxin‐induced interleukin‐10 production by SR 31747A, a sigma ligand

1995 • 38 citations

Most Nuclear Proteins Are Imported by a Single Pathway

1993 • 35 citations

Induction of kappa light chain synthesis in 70Z/3 B lymphoma cells by chemically defined lipid A precursors.

1988 • 34 citations

Endogenous Interleukin‐10 in Inflammatory Disorders: Regulatory Roles and Pharmacological Modulation

1996 • 30 citations

Importins/Karyopherins Meet Nucleoporins

1996 • 22 citations

Modulation of Nuclear Protein Import

1998 • 18 citations

Two Distinct Mechanisms of Interleukin-2 Gene Expression in Human T Lymphocytes

1989 • 9 citations