Differential capacities of the RGS1, RGS16 and RGS–GAIP regulators of G protein signaling to enhance α_2A‐adrenoreceptor agonist‐stimulated GTPase activity of G_o1α

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

1997 • 770 citations

GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits

1996 • 729 citations

The Regulator of G Protein Signaling Family

2000 • 586 citations

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

1996 • 547 citations

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

1996 • 470 citations

Regulators of G-Protein Signaling (RGS) Proteins: Region-Specific Expression of Nine Subtypes in Rat Brain

1997 • 437 citations

RGS4 and GAIP are GTPase-activating proteins for G _qα and block activation of phospholipase Cβ by γ-thio-GTP-G _qα

1997 • 355 citations

RGS10 is a selective activator of Gαi GTPase activity

1996 • 354 citations

RGS2/G0S8 is a selective inhibitor of Gqα function

1997 • 342 citations

RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K⁺ channels

1997 • 336 citations

Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity

1998 • 296 citations

GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain.

1995 • 291 citations

RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors

1999 • 256 citations

Emerging roles for RGS proteins in cell signalling

1999 • 255 citations

δ-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2

1990 • 252 citations

The N-terminal Domain of RGS4 Confers Receptor-selective Inhibition of G Protein Signaling

1998 • 235 citations

GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP

1998 • 222 citations

RGS8 accelerates G-protein-mediated modulation of K+currents

1997 • 221 citations

G Protein Selectivity Is a Determinant of RGS2 Function

1999 • 175 citations

A Point Mutation in Gαo and Gαi1Blocks Interaction with Regulator of G Protein Signaling Proteins

1998 • 172 citations

Characterization of a Novel Mammalian RGS Protein That Binds to Gα Proteins and Inhibits Pheromone Signaling in Yeast

1997 • 155 citations

RGSZ1, a Gz-selective RGS Protein in Brain

1998 • 144 citations

Regulators of G Protein Signaling 6 and 7

1999 • 136 citations

Cytoplasmic, Nuclear, and Golgi Localization of RGS Proteins

2000 • 135 citations

GPCR–Gα fusion proteins: molecular analysis of receptor–G-protein coupling

1999 • 121 citations

Insights into ligand pharmacology using receptor–G-protein fusion proteins

2000 • 101 citations

The Membrane Association Domain of RGS16 Contains Unique Amphipathic Features That Are Conserved in RGS4 and RGS5

1999 • 99 citations

Specific Regulation of RGS2 Messenger RNA by Angiotensin II in Cultured Vascular Smooth Muscle Cells

2000 • 97 citations

Hydrophobicity of Residue³⁵¹ of the G Protein G_i1α Determines the Extent of Activation by the α_2A-Adrenoceptor

1998 • 92 citations

Amino-terminal Cysteine Residues of RGS16 Are Required for Palmitoylation and Modulation of Gi- and Gq-mediated Signaling

1999 • 89 citations

The Regulator of G Protein Signaling RGS4 Selectively Enhances α2A-Adreoreceptor Stimulation of the GTPase Activity of Go1α and Gi2α

2000 • 68 citations

RGS1 Is Expressed in Monocytes and Acts as a GTPase-activating Protein for G-protein-coupled Chemoattractant Receptors

1999 • 62 citations

Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene

1998 • 50 citations

Measurement of agonist-induced guanine nucleotide turnover by the G-protein Gi1α when constrained within an α2A-adrenoceptor-Gi1α fusion protein

1997 • 49 citations

Rescue of Functional Interactions between the α2A-Adrenoreceptor and Acylation-resistant Forms of Gi1α by Expressing the Proteins from Chimeric Open Reading Frames

1997 • 48 citations

GAIP, a Gα_i-3-binding protein, is associated with Golgi-derived vesicles and protein trafficking

1999 • 44 citations

Measurement of agonist efficacy using an α_2A‐adrenoceptor‐G_i1α fusion protein

1997 • 35 citations

Modulation of Relative Intrinsic Activity of Agonists at theAlpha-2A Adrenoceptor by Mutation of Residue 351 of G Protein G_i1α

1999 • 31 citations

Structural Basis for the Selectivity of the RGS Protein, GAIP, for Gαi Family Members

1999 • 27 citations

An Asp⁷⁹Asn mutation of the α_2A‐adrenoceptor interferes equally with agonist activation of individual G_iα‐family G protein subtypes

1999 • 13 citations