Modulation of Relative Intrinsic Activity of Agonists at theAlpha-2A Adrenoceptor by Mutation of Residue 351 of G Protein G_i1α

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

The Many Faces of G Protein Signaling

1998 • 1,137 citations

A MODIFICATION OF RECEPTOR THEORY

1956 • 1,126 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

How receptors talk to trimeric G proteins

1997 • 562 citations

δ-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2

1990 • 252 citations

Partial agonists, full agonists, antagonists: dilemmas of definition

1993 • 234 citations

Constitutively active mutants of the alpha 2-adrenergic receptor

1993 • 234 citations

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation.

1995 • 204 citations

The D2 dopamine receptor isoforms signal through distinct Gi alpha proteins to inhibit adenylyl cyclase. A study with site-directed mutant Gi alpha proteins.

1994 • 191 citations

Ligand Efficacy and Potency at Recombinant α2 Adrenergic Receptors

1998 • 146 citations

Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.

1990 • 117 citations

Differential expression of the beta-adrenergic receptor modifies agonist stimulation of adenylyl cyclase: a quantitative evaluation.

1994 • 107 citations

The elusive nature of intrinsic efficacy

1998 • 102 citations

Hydrophobicity of Residue³⁵¹ of the G Protein G_i1α Determines the Extent of Activation by the α_2A-Adrenoceptor

1998 • 92 citations

Interactions of the α2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants

1997 • 77 citations

Heterotrimeric G proteins containing G alpha i3 regulate multiple effector enzymes in the same cell. Activation of phospholipases C and A2 and inhibition of adenylyl cyclase.

1994 • 65 citations

Agonist Occupation of an α2A-Adrenoreceptor-Gi1α Fusion Protein Results in Activation of Both Receptor-linked and Endogenous Gi Proteins

1998 • 59 citations

Analysis of the role of receptor number in defining the intrinsic activity and potency of partial agonists in neuroblastoma x glioma hybrid NG108-15 cells transfected to express differing levels of the human beta 2-adrenoceptor.

1995 • 55 citations

Measurement of agonist-induced guanine nucleotide turnover by the G-protein Gi1α when constrained within an α2A-adrenoceptor-Gi1α fusion protein

1997 • 49 citations

Rescue of Functional Interactions between the α2A-Adrenoreceptor and Acylation-resistant Forms of Gi1α by Expressing the Proteins from Chimeric Open Reading Frames

1997 • 48 citations

The Rat D4 Dopamine Receptor Couples to Cone Transducin (Gαt2) to Inhibit Forskolin-stimulated cAMP Accumulation

1997 • 36 citations

The Heterotrimeric G Protein Gαi2 Mediates Lysophosphatidic Acid-stimulated Induction of the c-fos Gene in Mouse Fibroblasts

1997 • 35 citations

Measurement of agonist efficacy using an α_2A‐adrenoceptor‐G_i1α fusion protein

1997 • 35 citations

Quantitative analysis of a cysteine³⁵¹glycine mutation in the G protein G_i1α: effect on α_2A‐adrenoceptor‐G_i1α fusion protein activation

1998 • 12 citations