Structural Basis for the Selectivity of the RGS Protein, GAIP, for Gαi Family Members

Experiments in molecular genetics

1972 • 28,260 citations

The Many Faces of G Protein Signaling

1998 • 1,137 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

1997 • 770 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits

1996 • 729 citations

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

1996 • 547 citations

Correlation of Two-Hybrid Affinity Data with In Vitro Measurements

1995 • 536 citations

RGS Proteins and Signaling by Heterotrimeric G Proteins

1997 • 522 citations

Mammalian RGS Proteins: Barbarians at the Gate

1998 • 487 citations

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

1996 • 470 citations

RGS4 and GAIP are GTPase-activating proteins for G _qα and block activation of phospholipase Cβ by γ-thio-GTP-G _qα

1997 • 355 citations

The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis

1996 • 354 citations

RGS10 is a selective activator of Gαi GTPase activity

1996 • 354 citations

RGS2/G0S8 is a selective inhibitor of Gqα function

1997 • 342 citations

Role of phosphorylation in desensitization of the β-adrenoceptor

1990 • 300 citations

GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain.

1995 • 291 citations

RGS8 accelerates G-protein-mediated modulation of K+currents

1997 • 221 citations

GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain

1998 • 218 citations

A new family of G-protein regulators — the RGS proteins

1997 • 201 citations

A Point Mutation in Gαo and Gαi1Blocks Interaction with Regulator of G Protein Signaling Proteins

1998 • 172 citations

Separate GTP Binding and GTPase Activating Domains of a Gα Subunit

1993 • 172 citations

The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro

1997 • 167 citations

GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of Gα _i subunits

1996 • 166 citations

Characterization of a Novel Mammalian RGS Protein That Binds to Gα Proteins and Inhibits Pheromone Signaling in Yeast

1997 • 155 citations

Inhibition of Brain G _z GAP and Other RGS Proteins by Palmitoylation of G Protein α Subunits

1997 • 147 citations

A Truncated Form of RGS3 Negatively Regulates G Protein-coupled Receptor Stimulation of Adenylyl Cyclase and Phosphoinositide Phospholipase C

1997 • 117 citations

Selective Uncoupling of RGS Action by a Single Point Mutation in the G Protein α-Subunit

1998 • 116 citations

Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway.

1990 • 108 citations

Potential Role for a Regulator of G Protein Signaling (RGS3) in Gonadotropin-Releasing Hormone (GnRH) Stimulated Desensitization

1997 • 92 citations

The core domain of a new retina specific RGS protein stimulates the GTPase activity of transducin in vitro

1997 • 90 citations

Regulation of Transducin GTPase Activity by Human Retinal RGS

1997 • 65 citations

RGS7 Attenuates Signal Transduction Through the G_αq Family of Heterotrimeric G Proteins in Mammalian Cells

1998 • 59 citations

Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins

1997 • 54 citations

A Single Mutation Asp²²⁹→ Ser Confers upon G_sα the Ability To Interact with Regulators of G Protein Signaling

1998 • 34 citations

Substitution of Transducin Ser202 by Asp Abolishes G-protein/RGS Interaction

1998 • 28 citations