Methylation Dynamics, Epigenetic Fidelity and X Chromosome Structure

DNA Methylation and Gene Function

1980 • 2,069 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin

1997 • 1,258 citations

Epigenetic mechanisms of gene regulation

1996 • 1,097 citations

The Inheritance of Epigenetic Defects

1987 • 1,058 citations

Spl elements protect a CpG island from de novo methylation

1994 • 713 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.

1994 • 597 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Altering gene expression with 5-azacytidine

1985 • 408 citations

DNA methylation errors and cancer.

1996 • 405 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

DNA methylation directs a time-dependent repression of transcription initiation

1997 • 372 citations

DNA methylation and imprinting: why bother?

1997 • 370 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

De Novo Methylation of CpG Island Sequences in Human Fibroblasts Overexpressing DNA (Cytosine-5-)-Methyltransferase

1996 • 290 citations

Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes

1994 • 277 citations

Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.

1990 • 264 citations

In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1.

1990 • 250 citations

DNA methyltransferases

1994 • 237 citations

Three-dimensional reconstruction of painted human interphase chromosomes: active and inactive X chromosome territories have similar volumes but differ in shape and surface structure.

1996 • 218 citations

Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR.

1991 • 195 citations

Preferential binding of estrogen-receptor complex to a region containing the estrogen-dependent hypomethylation site preceding the chicken vitellogenin II gene.

1984 • 184 citations

DNA methylation: A molecular lock

1997 • 179 citations

CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication.

1992 • 168 citations

Targeted transformation of Ascobolus immersus and de novo methylation of the resulting duplicated DNA sequences.

1989 • 158 citations

Imprinted Segments in the Human Genome: Different Dna Methylation Patterns in the Prader-Willi/Angelman Syndrome Region As Determined by the Genomic Sequencing Method

1997 • 143 citations

DNA Methylation and Development

2015 • 135 citations

Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist.

1995 • 111 citations

Reversible inactivation of a foreign gene, hph, during the asexual cycle in Neurospora crassa transformants

1992 • 87 citations

X chromosome inactivation and DNA methylation

1993 • 76 citations

Reactivation of inactive X‐linked genes

1994 • 67 citations

Mosaic Methylation in Clonal Tissue

1993 • 66 citations

DNA Methylation

1993 • 56 citations

Differences in methylation on the active and inactive human X chromosomes

1985 • 52 citations

Chromatin structural transitions and the phenomenon of vitellogenin gene memory in chickens.

1986 • 51 citations

CpG Island Promoter Region Methylation Patterns of the Inactive-X-Chromosome Hypoxanthine Phosphoribosyltransferase (Hprt) Gene

1994 • 40 citations

Delta-crystallin genes become hypomethylated in postmitotic lens cells during chicken development.

1987 • 35 citations

Metaphase chromosome analysis by ligation-mediated PCR: heritable chromatin structure and a comparison of active and inactive X chromosomes.

1995 • 28 citations

Methylation analysis by genomic sequencing of 5? region of mousePgk-1 gene and a cautionary note concerning the method

1993 • 27 citations

Isolation of a clone partially encoding hill kangaroo X-linked hypoxanthine phosphoribosyltransferase: Sex differences in methylation in the body of the gene

1993 • 26 citations

CpG island promoter region methylation patterns of the inactive-X-chromosome hypoxanthine phosphoribosyltransferase (Hprt) gene.

1994 • 26 citations

Methylation sensitive protein binding to an intragenic active X-specific methylated region in theM. robustus HPRT gene

1996 • 4 citations