Chapter 15 Food intake and leptin during pregnancy and lactation

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Central nervous system control of food intake

2000 • 6,305 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1996 • 1,505 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*

1999 • 1,467 citations

The Leptin Receptor

1997 • 1,300 citations

Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans

1997 • 1,299 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1996 • 1,170 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Leptin is a metabolic signal to the reproductive system.

1996 • 1,037 citations

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice

1996 • 873 citations

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight

1999 • 862 citations

Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin

1997 • 844 citations

Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

1998 • 753 citations

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

1995 • 716 citations

Metabolic fuels and reproduction in female mammals

1992 • 677 citations

Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats

1990 • 648 citations

An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat

1985 • 523 citations

Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta

1997 • 518 citations

Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus

1988 • 510 citations

Leptin Is a Metabolic Gate for the Onset of Puberty in the Female Rat

1997 • 506 citations

Coexpression of Leptin Receptor and Preproneuropeptide Y mRNA in Arcuate Nucleus of Mouse Hypothalamus

1996 • 473 citations

A Quantitative Analysis of the Roles of Dosage, Sequence, and Duration of Estradiol and Progesterone Exposure in the Regulation of Maternal Behavior in the Rat^*

1984 • 457 citations

Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*

1997 • 456 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism

1991 • 414 citations

Leptin Expression in Human Mammary Epithelial Cells and Breast Milk

1998 • 405 citations

Leptin is a metabolic signal to the reproductive system

1996 • 344 citations

Evidence for GnRH Regulation by Leptin: Leptin Administration Prevents Reduced Pulsatile LH Secretion during Fasting

1998 • 314 citations

Direct Intraovarian Effects of Leptin: Impairment of the Synergistic Action of Insulin-Like Growth Factor-I on Follicle-Stimulating Hormone-Dependent Estradiol-17β Production by Rat Ovarian Granulosa Cells*

1997 • 307 citations

Placental Leptin: An Important New Growth Factor in Intrauterine and Neonatal Development?

1997 • 307 citations

The effect of pregnancy and lactation on food intake, gastrointestinal anatomy and the absorptive capacity of the small intestine in the albino rat

1975 • 255 citations

Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

1996 • 232 citations

Variations in food and water intake in the normal and acyclic female rat

1971 • 202 citations

Leptin Is Present in Human Milk and Is Related to Maternal Plasma Leptin Concentration and Adiposity

1997 • 201 citations

Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat.

1993 • 174 citations

Leptin Is a Metabolic Gate for the Onset of Puberty in the Female Rat

1997 • 173 citations

Expression of placental leptin and leptin receptor transcripts in early pregnancy and at term

1998 • 172 citations

Differential expression of mRNA for leptin receptor isoforms in the rat brain

1997 • 172 citations

Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males

1997 • 169 citations

Influence of Endogenous Leptin Tone on the Estrous Cycle and Luteinizing Hormone Pulsatility in Female Rats

1997 • 158 citations

Daily Changes in Hypothalamic Gene Expression of Neuropeptide Y, Galanin, Proopiomelanocortin, and Adipocyte Leptin Gene Expression and Secretion: Effects of Food Restriction¹

1999 • 147 citations

Leptin Is Not Necessary for Gestation and Parturition But Regulates Maternal Nutrition via a Leptin Resistance State

1998 • 141 citations

Leptin in human pregnancy: The relationship with gestational hormones

1998 • 139 citations

The Placenta Is Not the Main Source of Leptin Production in Pregnant Rat: Gestational Profile of Leptin in Plasma and Adipose Tissues

1997 • 138 citations

Circulating Leptin Does Not Appear to Provide a Signal for Triggering the Initiation of Puberty in the Male Rhesus Monkey (Macaca Mulatta)

1997 • 135 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 134 citations

THE EFFECTS OF PROGESTERONE ON BODY WEIGHT AND COMPOSITION IN THE RAT

1967 • 133 citations

Inhibitory controls of feeding by the ventromedial hypothalamus

1974 • 130 citations

The utilization of protein and energy during lactation in the rat, with particular regard to the use of fat accumulated in pregnancy

1982 • 128 citations

Gestational Profile of Leptin Messenger Ribonucleic Acid (mRNA) Content in the Placenta and Adipose Tissue in the Rat, and Regulation of the mRNA Levels of the Leptin Receptor Subtypes in the Hypothalamus During Pregnancy and Lactation1

2000 • 127 citations

Concentrations of leptin in the serum of pregnant, lactating, and cycling rats and of leptin messenger ribonucleic acid in rat placental tissue

1998 • 125 citations

OB protein binds specifically to the choroid plexus of mice and rats.

1996 • 124 citations

Leptin Expression in Human Mammary Epithelial Cells and Breast Milk

1998 • 121 citations

Leptin Receptor of Zucker Fatty Rat Performs Reduced Signal Transduction

1997 • 119 citations

The Acute Suckling Stimulus Induces Expression of Neuropeptide Y (NPY) in Cells in the Dorsomedial Hypothalamus and Increases NPY Expression in the Arcuate Nucleus*

1998 • 119 citations

Neuropeptide Y, the hypothalamus, and diabetes: Insights into the central control of metabolism

1995 • 116 citations

Increase in Serum Leptin and Uterine Leptin Receptor Messenger RNA Levels during Pregnancy in Rats1

1997 • 115 citations

Increase of Mouse Leptin Production by Adipose Tissue after Midpregnancy: Gestational Profile of Serum Leptin Concentration

1997 • 108 citations

Periodicity of Food Intake and Lipogenesis in Rats Subjected to Two Different Feeding Plans

1970 • 101 citations

Suppression of Leptin During Lactation: Contribution of the Suckling StimulusVersusMilk Production¹

1999 • 101 citations

The Suppression of Pulsatile Luteinizing Hormone Secretion during Lactation in the Rat*

1984 • 97 citations

Direct Intraovarian Effects of Leptin: Impairment of the Synergistic Action of Insulin-Like Growth Factor-I on Follicle-Stimulating Hormone-Dependent Estradiol-17 Production by Rat Ovarian Granulosa Cells

1997 • 91 citations

Effect of food manipulation on the GnRH-LH-estradiol axis of young female rats

1988 • 89 citations

Lactation Suppresses Diurnal Rhythm of Serum Leptin

1998 • 86 citations

Lactation-dependent down regulation of leptin production in mouse mammary gland

1999 • 83 citations

Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: role of neuropeptide Y

1998 • 79 citations

Meal patterning in the lactating rat

1980 • 76 citations

Effect of Restricted Feed Intake on LH Levels in Female Rats

1972 • 66 citations

Expression of Neuropeptide Y Precursor-Immunoreactivity in the Hypothalamic Dopaminergic Tubero-Infundibular System during Lactation in Rodents*

1991 • 63 citations

The food intake of rats during pregnancy and lactation.

1984 • 62 citations

Postpartum and lactational estrus: A comparative analysis in rodentia.

1984 • 61 citations

Postpartum and lactational estrus: A comparative analysis in rodentia.

1984 • 60 citations

Circulating Leptin Does Not Appear to Provide a Signal for Triggering the Initiation of Puberty in the Male Rhesus Monkey (Macaca Mulatta)

1997 • 52 citations

Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat

1993 • 50 citations

Additive effects of lactation and food restriction to increase hypothalamic neuropeptide Y mRNA in rats

1997 • 46 citations

Relationships between hypothalamic neuropeptide Y and food intake in the lactating rat

1996 • 45 citations

Leptin Is Not Necessary for Gestation and Parturition But Regulates Maternal Nutrition via a Leptin Resistance State

1998 • 45 citations

Suppression of Leptin During Lactation: Contribution of the Suckling Stimulus Versus Milk Production

1999 • 45 citations

Serum Leptin Levels Do Not Rise during Pregnancy in Age-Matched Rats

1998 • 40 citations

Effect of acute food deprivation on lactational infertility in rats is reduced by leptin administration

1998 • 39 citations

Daily Changes in Hypothalamic Gene Expression of Neuropeptide Y, Galanin, Proopiomelanocortin, and Adipocyte Leptin Gene Expression and Secretion: Effects of Food Restriction

1999 • 38 citations

Effects of food restriction on the length of lactational diestrus in rats

1991 • 33 citations

The Acute Suckling Stimulus Induces Expression of Neuropeptide Y (NPY) in Cells in the Dorsomedial Hypothalamus and Increases NPY Expression in the Arcuate Nucleus

1998 • 31 citations

Suppression of LH secretion in food-restricted lactating females: effects of ovariectomy and bromocryptine treatment

1995 • 29 citations

Leptin receptor of Zucker fatty rat performs reduced signal transduction

1997 • 28 citations

Ovarian influences on food intake and body weight regulation in lactating rats

1976 • 24 citations

Effects of Progesterone on Pulsatile Luteinizing Hormone (LH) Secretion and LH Subunit Messenger Ribonucleic Acid during Lactation in the Rat*

1989 • 23 citations

Interaction of late pregnancy and lactation in rats

1999 • 17 citations

A possible control of food intake during pregnancy in the rat

1981 • 16 citations

Effects of food restriction during concurrent lactation and pregnancy in the rat

1987 • 15 citations

Neuropeptide Y receptor alterations in the hypothalamus of lactating rats

1999 • 10 citations