The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

The changing landscape of ischaemic brain injury mechanisms

1999 • 1,111 citations

Physiological consequences of loss of plasminogen activator gene function in mice

1994 • 1,051 citations

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

1995 • 659 citations

Structure and function of the NMDA receptor channel

1995 • 645 citations

Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

1998 • 629 citations

Tissue Plasminogen Activator Contributes to the Late Phase of LTP and to Synaptic Growth in the Hippocampal Mossy Fiber Pathway

1998 • 395 citations

Extracellular proteolysis in the adult murine brain.

1993 • 345 citations

Isolation and characterization of a human plasma protein with affinity for the lysine binding sites in plasminogen. Role in the regulation of fibrinolysis and identification as histidine-rich glycoprotein.

1980 • 289 citations

Distinct Influx Pathways, Not Calcium Load, Determine Neuronal Vulnerability to Calcium Neurotoxicity

1998 • 270 citations

The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.

1996 • 225 citations

Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator

1996 • 219 citations

Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus

1998 • 172 citations

Molecular analysis of blood vessel formation and disease

1997 • 163 citations

Tissue Plasminogen Activator (t-PA) Is Targeted to the Regulated Secretory Pathway

1997 • 161 citations

Nonproteolytic Neuroprotection by Human Recombinant Tissue Plasminogen Activator

1999 • 146 citations

Cytotoxicity in Murine Neocortical Cell Culture

1993 • 141 citations

Up‐regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor β1

1998 • 126 citations

Tetanus Toxin Blocks the Exocytosis of Synaptic Vesicles Clustered at Synapses But Not of Synaptic Vesicles in Isolated Axons

1999 • 95 citations

Origins of the specificity of tissue-type plasminogen activator.

1995 • 83 citations

Tissue plasminogen activator expression in the embryonic nervous system

1994 • 71 citations

Proteinase Specificity and Functional Diversity in Point Mutants of Plasminogen Activator Inhibitor 1

1997 • 45 citations

Australians seek international allies in battle over uranium mine

1999 • 41 citations

Engineering of conformations of plasminogen activator inhibitor‐1

1999 • 15 citations